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Peripheral and central distribution of TRPV1, substance P and CGRP of rat corneal neurons.
Brain Res. 2006 Apr 26; 1085(1):87-94.BR

Abstract

The rat corneal neurons expressing vanilloid receptor TRPV1, substance P (SP) and calcitonin-gene-related peptide (CGRP) were examined. In the cornea, some TRPV1-immunoreactive nerve fibers displayed either SP- or CGRP immunoreactivity also. For observing corneal neuronal elements in the trigeminal ganglion (TG) and in the medulla oblongata, retrograde and anterograde cholera toxin subunit B (CTB) tracing methods combining with triple immunofluorescence technique were performed. The corneal neuronal somata were located in the ophthalmic division of the TG; 37% of them were immunoreactive for TRPV1. One third and three quarters of the corneal TRPV1-immunoreactive neurons co-expressed SP and CGRP, respectively. All of SP-immunoreactive corneal neurons exhibited TRPV1 immunoreactivity. They were predominantly medium-sized (mean +/- SE = 638.2 +/- 49.5 microm(2)) and significantly larger than SP-immunoreactive and TRPV1-immunonegative neurons in the ophthalmic division of the TG. The central projection fibers of corneal neurons co-expressing TRPV1 with SP and CGRP were observed at the subnucleus interpolaris/caudalis transition within trigeminal nucleus. The present study suggests that TRPV1 of the corneal neurons works in close relation to SP and CGRP both in the cornea and CNS for healing and nociceptive transduction.

Authors+Show Affiliations

Division of Histology and Neuroanatomy, Department of Anatomy and Physiology, Faculty of Medicine, Saga University, Nabeshima 5-1-1, Saga 849-8501, Japan. murata@cc.saga-u.ac.jpNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16564032

Citation

Murata, Yuzo, and Sadahiko Masuko. "Peripheral and Central Distribution of TRPV1, Substance P and CGRP of Rat Corneal Neurons." Brain Research, vol. 1085, no. 1, 2006, pp. 87-94.
Murata Y, Masuko S. Peripheral and central distribution of TRPV1, substance P and CGRP of rat corneal neurons. Brain Res. 2006;1085(1):87-94.
Murata, Y., & Masuko, S. (2006). Peripheral and central distribution of TRPV1, substance P and CGRP of rat corneal neurons. Brain Research, 1085(1), 87-94.
Murata Y, Masuko S. Peripheral and Central Distribution of TRPV1, Substance P and CGRP of Rat Corneal Neurons. Brain Res. 2006 Apr 26;1085(1):87-94. PubMed PMID: 16564032.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peripheral and central distribution of TRPV1, substance P and CGRP of rat corneal neurons. AU - Murata,Yuzo, AU - Masuko,Sadahiko, Y1 - 2006/03/27/ PY - 2005/09/16/received PY - 2006/02/08/revised PY - 2006/02/10/accepted PY - 2006/3/28/pubmed PY - 2006/8/11/medline PY - 2006/3/28/entrez SP - 87 EP - 94 JF - Brain research JO - Brain Res. VL - 1085 IS - 1 N2 - The rat corneal neurons expressing vanilloid receptor TRPV1, substance P (SP) and calcitonin-gene-related peptide (CGRP) were examined. In the cornea, some TRPV1-immunoreactive nerve fibers displayed either SP- or CGRP immunoreactivity also. For observing corneal neuronal elements in the trigeminal ganglion (TG) and in the medulla oblongata, retrograde and anterograde cholera toxin subunit B (CTB) tracing methods combining with triple immunofluorescence technique were performed. The corneal neuronal somata were located in the ophthalmic division of the TG; 37% of them were immunoreactive for TRPV1. One third and three quarters of the corneal TRPV1-immunoreactive neurons co-expressed SP and CGRP, respectively. All of SP-immunoreactive corneal neurons exhibited TRPV1 immunoreactivity. They were predominantly medium-sized (mean +/- SE = 638.2 +/- 49.5 microm(2)) and significantly larger than SP-immunoreactive and TRPV1-immunonegative neurons in the ophthalmic division of the TG. The central projection fibers of corneal neurons co-expressing TRPV1 with SP and CGRP were observed at the subnucleus interpolaris/caudalis transition within trigeminal nucleus. The present study suggests that TRPV1 of the corneal neurons works in close relation to SP and CGRP both in the cornea and CNS for healing and nociceptive transduction. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/16564032/Peripheral_and_central_distribution_of_TRPV1_substance_P_and_CGRP_of_rat_corneal_neurons_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(06)00462-8 DB - PRIME DP - Unbound Medicine ER -