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Distribution of hepatitis C virus genotypes in the Middle East.
Int J Infect Dis. 2006 Jul; 10(4):272-7.IJ

Abstract

It is well established that hepatitis C develops into cirrhosis of the liver and hepatocellular carcinoma (HCC) both of which are fatal diseases. The World Health Organization estimates that there are at least 21.3 million hepatitis C virus (HCV) carriers in the Eastern Mediterranean countries, which is close to the number of carriers estimated in the Americas and Europe combined. With such a high disease burden of HCV infection in this part of the world, and in light of the new evidence that genotypes may influence the outcome of antiviral therapy, the focus of this review is on the epidemiology and distribution of HCV genotypes in the Eastern Mediterranean countries. Accumulated data show that there are two main patterns for the distribution of HCV genotypes in the Middle East: in the first pattern, genotype 4 is prevalent in most of the Arab countries, and in the second pattern, genotype 1a or 1b predominates in the non-Arab countries. Results from the limited number of clinical trials on the treatment of chronic HCV genotype 4 using peginterferon alfa-2b in combination with ribavirin are encouraging. However, efforts to develop more effective antiviral therapies and the establishment of an effective HCV vaccine remain the largest challenges for the near future.

Authors+Show Affiliations

Department of Medical Laboratory Technology, Faculty of Health Sciences, American University of Beirut, Riad El-Soloh, 1107-2020, Beirut, Lebanon. sramia@aub.edu.lbNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16564719

Citation

Ramia, S, and J Eid-Fares. "Distribution of Hepatitis C Virus Genotypes in the Middle East." International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, vol. 10, no. 4, 2006, pp. 272-7.
Ramia S, Eid-Fares J. Distribution of hepatitis C virus genotypes in the Middle East. Int J Infect Dis. 2006;10(4):272-7.
Ramia, S., & Eid-Fares, J. (2006). Distribution of hepatitis C virus genotypes in the Middle East. International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, 10(4), 272-7.
Ramia S, Eid-Fares J. Distribution of Hepatitis C Virus Genotypes in the Middle East. Int J Infect Dis. 2006;10(4):272-7. PubMed PMID: 16564719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distribution of hepatitis C virus genotypes in the Middle East. AU - Ramia,S, AU - Eid-Fares,J, Y1 - 2006/03/27/ PY - 2005/05/11/received PY - 2005/07/15/revised PY - 2005/07/21/accepted PY - 2006/3/28/pubmed PY - 2006/9/14/medline PY - 2006/3/28/entrez SP - 272 EP - 7 JF - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases JO - Int J Infect Dis VL - 10 IS - 4 N2 - It is well established that hepatitis C develops into cirrhosis of the liver and hepatocellular carcinoma (HCC) both of which are fatal diseases. The World Health Organization estimates that there are at least 21.3 million hepatitis C virus (HCV) carriers in the Eastern Mediterranean countries, which is close to the number of carriers estimated in the Americas and Europe combined. With such a high disease burden of HCV infection in this part of the world, and in light of the new evidence that genotypes may influence the outcome of antiviral therapy, the focus of this review is on the epidemiology and distribution of HCV genotypes in the Eastern Mediterranean countries. Accumulated data show that there are two main patterns for the distribution of HCV genotypes in the Middle East: in the first pattern, genotype 4 is prevalent in most of the Arab countries, and in the second pattern, genotype 1a or 1b predominates in the non-Arab countries. Results from the limited number of clinical trials on the treatment of chronic HCV genotype 4 using peginterferon alfa-2b in combination with ribavirin are encouraging. However, efforts to develop more effective antiviral therapies and the establishment of an effective HCV vaccine remain the largest challenges for the near future. SN - 1201-9712 UR - https://www.unboundmedicine.com/medline/citation/16564719/Distribution_of_hepatitis_C_virus_genotypes_in_the_Middle_East_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1201-9712(06)00012-9 DB - PRIME DP - Unbound Medicine ER -
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