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Neuroprotective effects of D-allose against retinal ischemia-reperfusion injury.
Invest Ophthalmol Vis Sci. 2006 Apr; 47(4):1653-7.IO

Abstract

PURPOSE

To investigate the effect of D-allose, a rare sugar, against ischemia reperfusion injury in the rat retina.

METHODS

Retinal ischemia was induced by increasing intraocular pressure to 130 mm Hg and maintaining that level for 45 minutes. Morphometric studies were performed to study the effect of D-allose on the histologic changes induced by ischemia in the rat retina. Glutamate release from the rat retina and intravitreal P(O2) profiles were monitored during and after ischemia with a microdialysis biosensor and oxygen-sensitive microelectrodes. The release of hydrogen peroxide stained with diaminobenzidine hydrochloride was monitored by an in vitro retinal ischemia model.

RESULTS

Seven days after the ischemia, significant reductions in both the number of ganglion cells and the thickness of the inner plexiform layer were observed. Pretreatment with D-allose significantly inhibited the ischemic injury of the inner retina. A large release of glutamate occurred during the ischemia. After the recirculation, glutamate levels were increased again and reached a maximum in approximately 20 minutes. The increases in extracellular glutamate during and after ischemia tend to be suppressed by administration of d-allose. d-Allose attenuated the increase in intravitreal P(O2) during reperfusion. After the ischemia, production of hydrogen peroxide was detected within approximately 30 minutes. D-allose suppressed the production of hydrogen peroxide.

CONCLUSIONS

These results suggest that D-allose may protect neurons by decreasing extracellular glutamate and attenuating oxidative stress in ischemic insult.

Authors+Show Affiliations

Department of Ophthalmology, Kagawa University Faculty of Medicine, Ikenobe, Miki, Japan. kazuyk@med.kagawa-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16565406

Citation

Hirooka, Kazuyuki, et al. "Neuroprotective Effects of D-allose Against Retinal Ischemia-reperfusion Injury." Investigative Ophthalmology & Visual Science, vol. 47, no. 4, 2006, pp. 1653-7.
Hirooka K, Miyamoto O, Jinming P, et al. Neuroprotective effects of D-allose against retinal ischemia-reperfusion injury. Invest Ophthalmol Vis Sci. 2006;47(4):1653-7.
Hirooka, K., Miyamoto, O., Jinming, P., Du, Y., Itano, T., Baba, T., Tokuda, M., & Shiraga, F. (2006). Neuroprotective effects of D-allose against retinal ischemia-reperfusion injury. Investigative Ophthalmology & Visual Science, 47(4), 1653-7.
Hirooka K, et al. Neuroprotective Effects of D-allose Against Retinal Ischemia-reperfusion Injury. Invest Ophthalmol Vis Sci. 2006;47(4):1653-7. PubMed PMID: 16565406.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective effects of D-allose against retinal ischemia-reperfusion injury. AU - Hirooka,Kazuyuki, AU - Miyamoto,Osamu, AU - Jinming,Pan, AU - Du,Yinghua, AU - Itano,Toshifumi, AU - Baba,Tetsuya, AU - Tokuda,Masaaki, AU - Shiraga,Fumio, PY - 2006/3/28/pubmed PY - 2006/4/28/medline PY - 2006/3/28/entrez SP - 1653 EP - 7 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 47 IS - 4 N2 - PURPOSE: To investigate the effect of D-allose, a rare sugar, against ischemia reperfusion injury in the rat retina. METHODS: Retinal ischemia was induced by increasing intraocular pressure to 130 mm Hg and maintaining that level for 45 minutes. Morphometric studies were performed to study the effect of D-allose on the histologic changes induced by ischemia in the rat retina. Glutamate release from the rat retina and intravitreal P(O2) profiles were monitored during and after ischemia with a microdialysis biosensor and oxygen-sensitive microelectrodes. The release of hydrogen peroxide stained with diaminobenzidine hydrochloride was monitored by an in vitro retinal ischemia model. RESULTS: Seven days after the ischemia, significant reductions in both the number of ganglion cells and the thickness of the inner plexiform layer were observed. Pretreatment with D-allose significantly inhibited the ischemic injury of the inner retina. A large release of glutamate occurred during the ischemia. After the recirculation, glutamate levels were increased again and reached a maximum in approximately 20 minutes. The increases in extracellular glutamate during and after ischemia tend to be suppressed by administration of d-allose. d-Allose attenuated the increase in intravitreal P(O2) during reperfusion. After the ischemia, production of hydrogen peroxide was detected within approximately 30 minutes. D-allose suppressed the production of hydrogen peroxide. CONCLUSIONS: These results suggest that D-allose may protect neurons by decreasing extracellular glutamate and attenuating oxidative stress in ischemic insult. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/16565406/Neuroprotective_effects_of_D_allose_against_retinal_ischemia_reperfusion_injury_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.05-1018 DB - PRIME DP - Unbound Medicine ER -