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Glycogen synthase kinase 3beta and Alzheimer's disease: pathophysiological and therapeutic significance.
Cell Mol Life Sci. 2006 Jun; 63(11):1226-35.CM

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder associated with cognitive and behavioral dysfunction and is the leading cause of dementia in the elderly. Several studies have implicated molecular and cellular signaling cascades involving the serine-threonine kinase, glycogen synthase kinase beta(GSK-3beta) in the pathogenesis of AD. GSK-3beta may play an important role in the formation of neurofibrillary tangles and senile plaques, the two classical pathological hallmarks of AD. In this review, we discuss the interaction between GSK-3beta and several key molecules involved in AD, including the presenilins, amyloid precursor protein, tau, and beta-amyloid. We identify the signal transduction pathways involved in the pathogenesis of AD, including Wnt, Notch, and the PI3 kinase/Akt pathway. These may be potential therapeutic targets in AD.

Authors+Show Affiliations

Balaraman Y
Division of Digestive Diseases, Emory University, Whitehead Research Building, Suite 246, 615 Michael Street, Atlanta, Georgia 30322, USA.
Limaye AR
No affiliation info available
Levey AI
No affiliation info available
Srinivasan S
No affiliation info available

MeSH

Alzheimer DiseaseEnzyme InhibitorsGlycogen Synthase KinasesHumansModels, Biological

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16568235

Citation

Balaraman, Y, et al. "Glycogen Synthase Kinase 3beta and Alzheimer's Disease: Pathophysiological and Therapeutic Significance." Cellular and Molecular Life Sciences : CMLS, vol. 63, no. 11, 2006, pp. 1226-35.
Balaraman Y, Limaye AR, Levey AI, et al. Glycogen synthase kinase 3beta and Alzheimer's disease: pathophysiological and therapeutic significance. Cell Mol Life Sci. 2006;63(11):1226-35.
Balaraman, Y., Limaye, A. R., Levey, A. I., & Srinivasan, S. (2006). Glycogen synthase kinase 3beta and Alzheimer's disease: pathophysiological and therapeutic significance. Cellular and Molecular Life Sciences : CMLS, 63(11), 1226-35.
Balaraman Y, et al. Glycogen Synthase Kinase 3beta and Alzheimer's Disease: Pathophysiological and Therapeutic Significance. Cell Mol Life Sci. 2006;63(11):1226-35. PubMed PMID: 16568235.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glycogen synthase kinase 3beta and Alzheimer's disease: pathophysiological and therapeutic significance. AU - Balaraman,Y, AU - Limaye,A R, AU - Levey,A I, AU - Srinivasan,S, PY - 2006/3/29/pubmed PY - 2006/7/26/medline PY - 2006/3/29/entrez SP - 1226 EP - 35 JF - Cellular and molecular life sciences : CMLS JO - Cell Mol Life Sci VL - 63 IS - 11 N2 - Alzheimer's disease (AD) is a neurodegenerative disorder associated with cognitive and behavioral dysfunction and is the leading cause of dementia in the elderly. Several studies have implicated molecular and cellular signaling cascades involving the serine-threonine kinase, glycogen synthase kinase beta(GSK-3beta) in the pathogenesis of AD. GSK-3beta may play an important role in the formation of neurofibrillary tangles and senile plaques, the two classical pathological hallmarks of AD. In this review, we discuss the interaction between GSK-3beta and several key molecules involved in AD, including the presenilins, amyloid precursor protein, tau, and beta-amyloid. We identify the signal transduction pathways involved in the pathogenesis of AD, including Wnt, Notch, and the PI3 kinase/Akt pathway. These may be potential therapeutic targets in AD. SN - 1420-682X UR - https://www.unboundmedicine.com/medline/citation/16568235/Glycogen_synthase_kinase_3beta_and_Alzheimer's_disease:_pathophysiological_and_therapeutic_significance_ DB - PRIME DP - Unbound Medicine ER -