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Chemical and biological assessment of a chinese herbal decoction containing Radix Astragali and Radix Angelicae Sinensis: Determination of drug ratio in having optimized properties.
J Agric Food Chem. 2006 Apr 05; 54(7):2767-74.JA

Abstract

Danggui Buxue Tang (DBT), a Chinese medicinal decoction that is commonly used as a dietary supplement in treating woman with menopausal irregularity, contains two herbs: Radix Astragali (Huangqi) and Radix Angelicae Sinensis (Danggui). The ratio of Radix Astragali and Radix Angelicae Sinensis used in DBT should be 5:1 as described in China in 1247 A.D.; however, the rationale of this formula has not been given. Here, the chemical and biological properties of DBT, prepared from different ratios of the drugs, were determined. Significantly, higher amounts of Radix Astragali-derived astragaloside IV, calycosin, and formononetin and Radix Angelicae Sinensis-derived ferulic acid were found in DBT with Radix Astragali and Radix Angelicae Sinensis in a 5:1 ratio. By using the biological effects of DBT in stimulating osteoblast proliferation, estrogen promoter activation, and anti-platelet aggregation activity, the drug ratio of 5:1 produced the best effects. In addition, the use of ethanol-treated Radix Angelicae Sinensis enhanced the efficacy of DBT, and the treatment further increased the solubilities of chemical constituents. By analyzing the correlation of chemical and biological results, several chemicals showed positive correlation with DBT-induced bioactivities. The current results support the ancient formulation of DBT, and the identified chemicals could serve as markers for quality control of DBT.

Authors+Show Affiliations

Dong TT
Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay Road, Hong Kong, China.
Zhao KJ
No affiliation info available
Gao QT
No affiliation info available
Ji ZN
No affiliation info available
Zhu TT
No affiliation info available
Li J
No affiliation info available
Duan R
No affiliation info available
Cheung AW
No affiliation info available
Tsim KW
No affiliation info available

MeSH

Angelica sinensisAstragalus propinquusCell DivisionCell Line, TumorCoumaric AcidsDrugs, Chinese HerbalHumansIsoflavonesOsteoblastsPlant RootsPlatelet Aggregation InhibitorsPromoter Regions, GeneticReceptors, EstrogenSaponinsTriterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16569074

Citation

Dong, Tina T X., et al. "Chemical and Biological Assessment of a Chinese Herbal Decoction Containing Radix Astragali and Radix Angelicae Sinensis: Determination of Drug Ratio in Having Optimized Properties." Journal of Agricultural and Food Chemistry, vol. 54, no. 7, 2006, pp. 2767-74.
Dong TT, Zhao KJ, Gao QT, et al. Chemical and biological assessment of a chinese herbal decoction containing Radix Astragali and Radix Angelicae Sinensis: Determination of drug ratio in having optimized properties. J Agric Food Chem. 2006;54(7):2767-74.
Dong, T. T., Zhao, K. J., Gao, Q. T., Ji, Z. N., Zhu, T. T., Li, J., Duan, R., Cheung, A. W., & Tsim, K. W. (2006). Chemical and biological assessment of a chinese herbal decoction containing Radix Astragali and Radix Angelicae Sinensis: Determination of drug ratio in having optimized properties. Journal of Agricultural and Food Chemistry, 54(7), 2767-74.
Dong TT, et al. Chemical and Biological Assessment of a Chinese Herbal Decoction Containing Radix Astragali and Radix Angelicae Sinensis: Determination of Drug Ratio in Having Optimized Properties. J Agric Food Chem. 2006 Apr 5;54(7):2767-74. PubMed PMID: 16569074.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical and biological assessment of a chinese herbal decoction containing Radix Astragali and Radix Angelicae Sinensis: Determination of drug ratio in having optimized properties. AU - Dong,Tina T X, AU - Zhao,Kui J, AU - Gao,Qiu T, AU - Ji,Zhao N, AU - Zhu,Ting T, AU - Li,Jun, AU - Duan,Ran, AU - Cheung,Anna W H, AU - Tsim,Karl W K, PY - 2006/3/30/pubmed PY - 2006/4/29/medline PY - 2006/3/30/entrez SP - 2767 EP - 74 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 54 IS - 7 N2 - Danggui Buxue Tang (DBT), a Chinese medicinal decoction that is commonly used as a dietary supplement in treating woman with menopausal irregularity, contains two herbs: Radix Astragali (Huangqi) and Radix Angelicae Sinensis (Danggui). The ratio of Radix Astragali and Radix Angelicae Sinensis used in DBT should be 5:1 as described in China in 1247 A.D.; however, the rationale of this formula has not been given. Here, the chemical and biological properties of DBT, prepared from different ratios of the drugs, were determined. Significantly, higher amounts of Radix Astragali-derived astragaloside IV, calycosin, and formononetin and Radix Angelicae Sinensis-derived ferulic acid were found in DBT with Radix Astragali and Radix Angelicae Sinensis in a 5:1 ratio. By using the biological effects of DBT in stimulating osteoblast proliferation, estrogen promoter activation, and anti-platelet aggregation activity, the drug ratio of 5:1 produced the best effects. In addition, the use of ethanol-treated Radix Angelicae Sinensis enhanced the efficacy of DBT, and the treatment further increased the solubilities of chemical constituents. By analyzing the correlation of chemical and biological results, several chemicals showed positive correlation with DBT-induced bioactivities. The current results support the ancient formulation of DBT, and the identified chemicals could serve as markers for quality control of DBT. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/16569074/Chemical_and_biological_assessment_of_a_chinese_herbal_decoction_containing_Radix_Astragali_and_Radix_Angelicae_Sinensis:_Determination_of_drug_ratio_in_having_optimized_properties_ DB - PRIME DP - Unbound Medicine ER -
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