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Mechanisms of CB1 receptor signaling: endocannabinoid modulation of synaptic strength.
Int J Obes (Lond). 2006 Apr; 30 Suppl 1:S19-23.IJ

Abstract

The CB1 cannabinoid receptor has attracted much recent interest because of the observation that CB1 receptor antagonists have efficacy in treating metabolic syndrome and obesity. CB1 receptors also mediate most of the psychotropic effects of Delta9-tetrahydrocannabinol (Delta9THC), the principal psychoactive component of cannabis. In addition, they are one component of an interesting and widespread paracrine signaling system, the endocannabinoid system. The endocannabinoid system is comprised of cannabinoid receptors, endogenous cannabinoids, and the metabolic pathways responsible for their synthesis and degradation. The details of the endocannabinoid system have been most thoroughly studied in the brain. Here it has been shown to be intimately involved in several forms of neuronal plasticity. That is, activation of CB1 receptors by endocannabinoids produces either short- or long-term changes in the efficacy of synaptic transmission. The behavioral consequences of these changes are many, but some of the most striking and relevant to the current symposium are those associated with endogenous reward and consumptive behavior.

Authors+Show Affiliations

Department of Anesthesiology, University of Washington School of Medicine, Seattle, WA 98195-6540, USA. kmackie@u.washington.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16570100

Citation

Mackie, K. "Mechanisms of CB1 Receptor Signaling: Endocannabinoid Modulation of Synaptic Strength." International Journal of Obesity (2005), vol. 30 Suppl 1, 2006, pp. S19-23.
Mackie K. Mechanisms of CB1 receptor signaling: endocannabinoid modulation of synaptic strength. Int J Obes (Lond). 2006;30 Suppl 1:S19-23.
Mackie, K. (2006). Mechanisms of CB1 receptor signaling: endocannabinoid modulation of synaptic strength. International Journal of Obesity (2005), 30 Suppl 1, S19-23.
Mackie K. Mechanisms of CB1 Receptor Signaling: Endocannabinoid Modulation of Synaptic Strength. Int J Obes (Lond). 2006;30 Suppl 1:S19-23. PubMed PMID: 16570100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanisms of CB1 receptor signaling: endocannabinoid modulation of synaptic strength. A1 - Mackie,K, PY - 2006/3/30/pubmed PY - 2006/8/9/medline PY - 2006/3/30/entrez SP - S19 EP - 23 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 30 Suppl 1 N2 - The CB1 cannabinoid receptor has attracted much recent interest because of the observation that CB1 receptor antagonists have efficacy in treating metabolic syndrome and obesity. CB1 receptors also mediate most of the psychotropic effects of Delta9-tetrahydrocannabinol (Delta9THC), the principal psychoactive component of cannabis. In addition, they are one component of an interesting and widespread paracrine signaling system, the endocannabinoid system. The endocannabinoid system is comprised of cannabinoid receptors, endogenous cannabinoids, and the metabolic pathways responsible for their synthesis and degradation. The details of the endocannabinoid system have been most thoroughly studied in the brain. Here it has been shown to be intimately involved in several forms of neuronal plasticity. That is, activation of CB1 receptors by endocannabinoids produces either short- or long-term changes in the efficacy of synaptic transmission. The behavioral consequences of these changes are many, but some of the most striking and relevant to the current symposium are those associated with endogenous reward and consumptive behavior. SN - 0307-0565 UR - https://www.unboundmedicine.com/medline/citation/16570100/Mechanisms_of_CB1_receptor_signaling:_endocannabinoid_modulation_of_synaptic_strength_ L2 - https://doi.org/10.1038/sj.ijo.0803273 DB - PRIME DP - Unbound Medicine ER -