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[A study of the properties of tablets from mixtures of two size degrees of alpha-lactose monohydrate and microcrystalline cellulose].
Ceska Slov Farm. 2006 Mar; 55(2):72-7.CS

Abstract

The paper examines the strength and disintegration time of compacts from the mixtures of two types of Tablettosas. Tablettosa 70 and Tablettosa 100 with microcrystalline cellulose represented by Vivapur 102. The mixtures of dry binders were prepared in the ratios of 3:1, 1:1, and 1:3. The effect of two concentrations of the lubricant magnesium stearate on the strength and disintegration time of compacts was also examined. Tablet strength increased with higher representation of microcrystalline cellulose in the mixture, and decreased with higher stearate concentration. The compacts from the mixtures with Tablettosa 100 showed higher strength. Disintegration time was highest in the compacts with the largest perccintage of microcrystalline cellulose, and longer in the case of the mixtures with Tablettosa 100. Stearate did not exert a negative effect on disintegration time. In the mixtures of Tablettosas with Vivapur 102 in a ratio of 1:1, the effect of the model active ingredient acetylsalicylic acid on the above-mentioned properties of tablets was tested. acetylsalicylic acid produced a further decrease in the strength of compacts and shortened the disintegration time in more instances in the cased of the mixtures with Tahlettosa 100.

Authors+Show Affiliations

Muzíková J
Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové, Katedra farmaceutické technologie. muzikova@faf.cuni.cz

MeSH

AspirinCelluloseDrug CompoundingExcipientsLactosePharmaceutic AidsSolubilityTabletsTechnology, Pharmaceutical

Pub Type(s)

Journal Article

Language

cze

PubMed ID

16570584

Citation

Muzíková, J. "[A Study of the Properties of Tablets From Mixtures of Two Size Degrees of Alpha-lactose Monohydrate and Microcrystalline Cellulose]." Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti, vol. 55, no. 2, 2006, pp. 72-7.
Muzíková J. [A study of the properties of tablets from mixtures of two size degrees of alpha-lactose monohydrate and microcrystalline cellulose]. Ceska Slov Farm. 2006;55(2):72-7.
Muzíková, J. (2006). [A study of the properties of tablets from mixtures of two size degrees of alpha-lactose monohydrate and microcrystalline cellulose]. Ceska a Slovenska Farmacie : Casopis Ceske Farmaceuticke Spolecnosti a Slovenske Farmaceuticke Spolecnosti, 55(2), 72-7.
Muzíková J. [A Study of the Properties of Tablets From Mixtures of Two Size Degrees of Alpha-lactose Monohydrate and Microcrystalline Cellulose]. Ceska Slov Farm. 2006;55(2):72-7. PubMed PMID: 16570584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A study of the properties of tablets from mixtures of two size degrees of alpha-lactose monohydrate and microcrystalline cellulose]. A1 - Muzíková,J, PY - 2006/3/31/pubmed PY - 2006/5/25/medline PY - 2006/3/31/entrez SP - 72 EP - 7 JF - Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti JO - Ceska Slov Farm VL - 55 IS - 2 N2 - The paper examines the strength and disintegration time of compacts from the mixtures of two types of Tablettosas. Tablettosa 70 and Tablettosa 100 with microcrystalline cellulose represented by Vivapur 102. The mixtures of dry binders were prepared in the ratios of 3:1, 1:1, and 1:3. The effect of two concentrations of the lubricant magnesium stearate on the strength and disintegration time of compacts was also examined. Tablet strength increased with higher representation of microcrystalline cellulose in the mixture, and decreased with higher stearate concentration. The compacts from the mixtures with Tablettosa 100 showed higher strength. Disintegration time was highest in the compacts with the largest perccintage of microcrystalline cellulose, and longer in the case of the mixtures with Tablettosa 100. Stearate did not exert a negative effect on disintegration time. In the mixtures of Tablettosas with Vivapur 102 in a ratio of 1:1, the effect of the model active ingredient acetylsalicylic acid on the above-mentioned properties of tablets was tested. acetylsalicylic acid produced a further decrease in the strength of compacts and shortened the disintegration time in more instances in the cased of the mixtures with Tahlettosa 100. SN - 1210-7816 UR - https://www.unboundmedicine.com/medline/citation/16570584/[A_study_of_the_properties_of_tablets_from_mixtures_of_two_size_degrees_of_alpha_lactose_monohydrate_and_microcrystalline_cellulose]_ DB - PRIME DP - Unbound Medicine ER -