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[Studies on antitumor effects of podophyllotoxin nanoliposome].
Zhongguo Zhong Yao Za Zhi. 2006 Jan; 31(2):148-50.ZZ

Abstract

OBJECTIVE

To compare the antitumor effects of the podophyllotoxin nanoliposome and the suspensions of podophyllotoxin in bearing-tumor mice.

METHOD

The experimental mice were inoculated by suspension liquid of tumor cell in axillary region near the forelimb, 0.2 mL each. The mice had been randomly divided into 8 groups 24 h latter. The podophyllotoxin nanoliposome, suspension liquid of the podophyllotoxin, CX or NS was given to each group respectively. Except CX was given by celiac injection once, the other groups were injected every 4 days for three times. The mice were killed by hauling necks on the twelfth day after treatment, the tumor was weighed and the inhibitory rate was calculated.

RESULT

When the dosage of podophyllotoxin nanoliposome and the suspensions of podophyllotoxin reached 5.0 mg x kg(-1), the rate of inhibiting tumor were 52.37% and 38.25% to the H22 liver cancer of mice respectively.

CONCLUSION

Podophyllotoxin nanoliposome and the suspensions of podophyllotoxin have the effect in anti-liver cancer. And podophyllotoxin nanoliposome have stronger inhibitory rate compared with suspension liquid of the podophyllotoxin in same dose.

Links

clones/clone libraries

Authors+Show Affiliations

Zhang XY
Department of Pharmacy, Lanzhou University, Lanzhou 730000, China.
Ni JM
No affiliation info available
Qiao H
No affiliation info available

MeSH

AnimalsAntineoplastic Agents, PhytogenicCarcinoma, HepatocellularCell Line, TumorFemaleHumansLiposomesLiver NeoplasmsMiceNanostructuresNeoplasm TransplantationPodophyllotoxinRandom Allocation

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

16570806

Citation

Zhang, Xiao-Yun, et al. "[Studies On Antitumor Effects of Podophyllotoxin Nanoliposome]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 31, no. 2, 2006, pp. 148-50.
Zhang XY, Ni JM, Qiao H. [Studies on antitumor effects of podophyllotoxin nanoliposome]. Zhongguo Zhong Yao Za Zhi. 2006;31(2):148-50.
Zhang, X. Y., Ni, J. M., & Qiao, H. (2006). [Studies on antitumor effects of podophyllotoxin nanoliposome]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 31(2), 148-50.
Zhang XY, Ni JM, Qiao H. [Studies On Antitumor Effects of Podophyllotoxin Nanoliposome]. Zhongguo Zhong Yao Za Zhi. 2006;31(2):148-50. PubMed PMID: 16570806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Studies on antitumor effects of podophyllotoxin nanoliposome]. AU - Zhang,Xiao-Yun, AU - Ni,Jing-Man, AU - Qiao,Hua, PY - 2006/3/31/pubmed PY - 2006/7/26/medline PY - 2006/3/31/entrez SP - 148 EP - 50 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 31 IS - 2 N2 - OBJECTIVE: To compare the antitumor effects of the podophyllotoxin nanoliposome and the suspensions of podophyllotoxin in bearing-tumor mice. METHOD: The experimental mice were inoculated by suspension liquid of tumor cell in axillary region near the forelimb, 0.2 mL each. The mice had been randomly divided into 8 groups 24 h latter. The podophyllotoxin nanoliposome, suspension liquid of the podophyllotoxin, CX or NS was given to each group respectively. Except CX was given by celiac injection once, the other groups were injected every 4 days for three times. The mice were killed by hauling necks on the twelfth day after treatment, the tumor was weighed and the inhibitory rate was calculated. RESULT: When the dosage of podophyllotoxin nanoliposome and the suspensions of podophyllotoxin reached 5.0 mg x kg(-1), the rate of inhibiting tumor were 52.37% and 38.25% to the H22 liver cancer of mice respectively. CONCLUSION: Podophyllotoxin nanoliposome and the suspensions of podophyllotoxin have the effect in anti-liver cancer. And podophyllotoxin nanoliposome have stronger inhibitory rate compared with suspension liquid of the podophyllotoxin in same dose. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/16570806/[Studies_on_antitumor_effects_of_podophyllotoxin_nanoliposome]_ L2 - https://medlineplus.gov/livercancer.html DB - PRIME DP - Unbound Medicine ER -