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Vitamin D status of 51-75-year-old Irish women: its determinants and impact on biochemical indices of bone turnover.
Public Health Nutr 2006; 9(2):225-33PH

Abstract

OBJECTIVES

To assess the vitamin D status of Irish postmenopausal women during wintertime, and to examine its relationship with serum parathyroid hormone (PTH) and biochemical markers of bone turnover. In addition, the determinants of wintertime serum 25-hydroxyvitamin D (25OH-D) levels in these women were investigated.

DESIGN

A cross-sectional observational study.

SETTING

Cork City, Ireland (52 degrees N).

SUBJECTS

Ninety-five apparently healthy, free-living postmenopausal women (aged 51-75 years), not taking any medication and free from any condition likely to affect vitamin D status or calcium/bone metabolism.

RESULTS

Forty-eight per cent and 7% of women had serum 25OH-D levels <50 nmol l(-1) and <25 nmol l(-1), respectively. 25OH-D levels in these women were positively associated with dietary calcium intake (P = 0.0002) and use of vitamin D-containing supplements (P = 0.031), and negatively associated with cigarette smoking (P = 0.027) and body mass index (BMI) (P = 0.030). Low serum 25OH-D levels (<50 nmol l(-1)) were associated (P < 0.01) with elevated serum PTH levels. There were no significant differences in urinary pyridinium crosslinks or serum osteocalcin, biochemical indices of bone turnover, between subjects with serum 25OH-D levels above or below 50 nmol l(-1).

CONCLUSION

A high proportion of Irish postmenopausal women had low vitamin D status (<50 nmol l(-1)) during late wintertime, which appeared to lead to elevated levels of serum PTH but not of bone turnover markers. Use of regular low-dose supplemental vitamin D, meeting daily calcium recommendations, cessation of smoking and maintaining BMI in the normal range are important factors that could help maintain adequate vitamin D levels during wintertime in these women.

Authors+Show Affiliations

Department of Food and Nutritional Sciences, University College, Cork, Ireland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16571177

Citation

Hill, Tom R., et al. "Vitamin D Status of 51-75-year-old Irish Women: Its Determinants and Impact On Biochemical Indices of Bone Turnover." Public Health Nutrition, vol. 9, no. 2, 2006, pp. 225-33.
Hill TR, O'Brien MM, Lamberg-Allardt C, et al. Vitamin D status of 51-75-year-old Irish women: its determinants and impact on biochemical indices of bone turnover. Public Health Nutr. 2006;9(2):225-33.
Hill, T. R., O'Brien, M. M., Lamberg-Allardt, C., Jakobsen, J., Kiely, M., Flynn, A., & Cashman, K. D. (2006). Vitamin D status of 51-75-year-old Irish women: its determinants and impact on biochemical indices of bone turnover. Public Health Nutrition, 9(2), pp. 225-33.
Hill TR, et al. Vitamin D Status of 51-75-year-old Irish Women: Its Determinants and Impact On Biochemical Indices of Bone Turnover. Public Health Nutr. 2006;9(2):225-33. PubMed PMID: 16571177.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D status of 51-75-year-old Irish women: its determinants and impact on biochemical indices of bone turnover. AU - Hill,Tom R, AU - O'Brien,Maria M, AU - Lamberg-Allardt,Christel, AU - Jakobsen,Jette, AU - Kiely,Mairead, AU - Flynn,Albert, AU - Cashman,Kevin D, PY - 2006/3/31/pubmed PY - 2006/8/29/medline PY - 2006/3/31/entrez SP - 225 EP - 33 JF - Public health nutrition JO - Public Health Nutr VL - 9 IS - 2 N2 - OBJECTIVES: To assess the vitamin D status of Irish postmenopausal women during wintertime, and to examine its relationship with serum parathyroid hormone (PTH) and biochemical markers of bone turnover. In addition, the determinants of wintertime serum 25-hydroxyvitamin D (25OH-D) levels in these women were investigated. DESIGN: A cross-sectional observational study. SETTING: Cork City, Ireland (52 degrees N). SUBJECTS: Ninety-five apparently healthy, free-living postmenopausal women (aged 51-75 years), not taking any medication and free from any condition likely to affect vitamin D status or calcium/bone metabolism. RESULTS: Forty-eight per cent and 7% of women had serum 25OH-D levels <50 nmol l(-1) and <25 nmol l(-1), respectively. 25OH-D levels in these women were positively associated with dietary calcium intake (P = 0.0002) and use of vitamin D-containing supplements (P = 0.031), and negatively associated with cigarette smoking (P = 0.027) and body mass index (BMI) (P = 0.030). Low serum 25OH-D levels (<50 nmol l(-1)) were associated (P < 0.01) with elevated serum PTH levels. There were no significant differences in urinary pyridinium crosslinks or serum osteocalcin, biochemical indices of bone turnover, between subjects with serum 25OH-D levels above or below 50 nmol l(-1). CONCLUSION: A high proportion of Irish postmenopausal women had low vitamin D status (<50 nmol l(-1)) during late wintertime, which appeared to lead to elevated levels of serum PTH but not of bone turnover markers. Use of regular low-dose supplemental vitamin D, meeting daily calcium recommendations, cessation of smoking and maintaining BMI in the normal range are important factors that could help maintain adequate vitamin D levels during wintertime in these women. SN - 1368-9800 UR - https://www.unboundmedicine.com/medline/citation/16571177/Vitamin_D_status_of_51_75_year_old_Irish_women:_its_determinants_and_impact_on_biochemical_indices_of_bone_turnover_ L2 - https://www.cambridge.org/core/product/identifier/S1368980006000425/type/journal_article DB - PRIME DP - Unbound Medicine ER -