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Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study.
Carcinogenesis 2006; 27(7):1497-501C

Abstract

The risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC). The study included 521,457 individuals and 314 incident cases of GC that had occurred after 6.6 average years of follow-up. An index of endogenous NOC (ENOC) formation was estimated using data of the iron content from meat intake and faecal apparent total NOC formation according to previous published studies. Antibodies to Helicobacter pylori and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control within the cohort. Exposure to NDMA was < 1 microg on average compared with 93 mug on average from ENOC. There was no association between NDMA intake and GC risk (HR, 1.00; 95% CI, 0.7-1.43). ENOC was significantly associated with non-cardia cancer risk (HR, 1.42; 95% CI, 1.14-1.78 for an increase of 40 microg/day) but not with cardia cancer (HR, 0.96; 95% CI, 0.69-1.33). Although the number of not infected cases is low, our data suggest a possible interaction between ENOC and H.pylori infection (P for interaction = 0.09). Moreover, we observed an interaction between plasma vitamin C and ENOC (P < 0.02). ENOC formation may account for our previously reported association between red and processed meat consumption and gastric cancer risk.

Authors+Show Affiliations

Department of Epidemiology, Catalan Institute of Oncology, (ICO-IDIBELL) Barcelona, Spain. paujak@ico.scs.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16571648

Citation

Jakszyn, Paula, et al. "Endogenous Versus Exogenous Exposure to N-nitroso Compounds and Gastric Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC-EURGAST) Study." Carcinogenesis, vol. 27, no. 7, 2006, pp. 1497-501.
Jakszyn P, Bingham S, Pera G, et al. Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study. Carcinogenesis. 2006;27(7):1497-501.
Jakszyn, P., Bingham, S., Pera, G., Agudo, A., Luben, R., Welch, A., ... Gonzalez, C. A. (2006). Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study. Carcinogenesis, 27(7), pp. 1497-501.
Jakszyn P, et al. Endogenous Versus Exogenous Exposure to N-nitroso Compounds and Gastric Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC-EURGAST) Study. Carcinogenesis. 2006;27(7):1497-501. PubMed PMID: 16571648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study. AU - Jakszyn,Paula, AU - Bingham,Sheila, AU - Pera,Guillem, AU - Agudo,Antonio, AU - Luben,Robert, AU - Welch,Ailsa, AU - Boeing,Heiner, AU - Del Giudice,Giuseppe, AU - Palli,Domenico, AU - Saieva,Calogero, AU - Krogh,Vittorio, AU - Sacerdote,Carlotta, AU - Tumino,Rosario, AU - Panico,Salvatore, AU - Berglund,Göran, AU - Simán,Henrik, AU - Hallmans,Göran, AU - Sanchez,María José, AU - Larrañaga,Nerea, AU - Barricarte,Aurelio, AU - Chirlaque,María Dolores, AU - Quirós,José R, AU - Key,Timothy J, AU - Allen,Naomi, AU - Lund,Eiliv, AU - Carneiro,Fátima, AU - Linseisen,Jakob, AU - Nagel,Gabriele, AU - Overvad,Kim, AU - Tjonneland,Anne, AU - Olsen,Anja, AU - Bueno-de-Mesquita,H Bas, AU - Ocké,Marga O, AU - Peeters,Petra Hm, AU - Numans,Mattijs E, AU - Clavel-Chapelon,Françoise, AU - Trichopoulou,Antonia, AU - Fenger,Claus, AU - Stenling,Roger, AU - Ferrari,Pietro, AU - Jenab,Mazda, AU - Norat,Teresa, AU - Riboli,Elio, AU - Gonzalez,Carlos A, Y1 - 2006/03/29/ PY - 2006/3/31/pubmed PY - 2006/8/23/medline PY - 2006/3/31/entrez SP - 1497 EP - 501 JF - Carcinogenesis JO - Carcinogenesis VL - 27 IS - 7 N2 - The risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC). The study included 521,457 individuals and 314 incident cases of GC that had occurred after 6.6 average years of follow-up. An index of endogenous NOC (ENOC) formation was estimated using data of the iron content from meat intake and faecal apparent total NOC formation according to previous published studies. Antibodies to Helicobacter pylori and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control within the cohort. Exposure to NDMA was < 1 microg on average compared with 93 mug on average from ENOC. There was no association between NDMA intake and GC risk (HR, 1.00; 95% CI, 0.7-1.43). ENOC was significantly associated with non-cardia cancer risk (HR, 1.42; 95% CI, 1.14-1.78 for an increase of 40 microg/day) but not with cardia cancer (HR, 0.96; 95% CI, 0.69-1.33). Although the number of not infected cases is low, our data suggest a possible interaction between ENOC and H.pylori infection (P for interaction = 0.09). Moreover, we observed an interaction between plasma vitamin C and ENOC (P < 0.02). ENOC formation may account for our previously reported association between red and processed meat consumption and gastric cancer risk. SN - 0143-3334 UR - https://www.unboundmedicine.com/medline/citation/16571648/Endogenous_versus_exogenous_exposure_to_N_nitroso_compounds_and_gastric_cancer_risk_in_the_European_Prospective_Investigation_into_Cancer_and_Nutrition__EPIC_EURGAST__study_ L2 - https://academic.oup.com/carcin/article-lookup/doi/10.1093/carcin/bgl019 DB - PRIME DP - Unbound Medicine ER -