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Incorporation into liver microsomal lipids of linoleic and stearic acids and of their respective products of delta 6 and delta 9 desaturation, gamma-linolenic and oleic acids: effect of age and of blackcurrant seed oil.
Biochim Biophys Acta. 1991 Nov 05; 1086(2):230-6.BB

Abstract

The incorporation of [1-14C]linoleic and [1-14C]stearic acid and of their delta 6 and delta 9 desaturation products (gamma-linolenic and oleic acids, respectively) into different classes of lipids was studied in liver microsomes of rats in function of the diet (blackcurrant seed oil diet, containing gamma-linolenic acid, versus control diet) and in function of age (3, 6 and 9 months). After delta 6 desaturation, total radioactivity was distributed between phospholipids, especially phosphatidylcholine, and neutral lipids. The desaturation product, gamma-linolenic acid, was totally recovered in the phospholipid fraction. Blackcurrant seed oil, which decreased the rate of delta 6 desaturation in 6- and 9-month-old rats, also decreased the incorporation of radioactivity in total phospholipids, especially in phosphatidylcholine. At 6 months of age, after delta 9 desaturation, the majority of radioactivity was recovered in neutral lipids principally as oleic acid, the desaturation product. The precursor, stearic acid, was highly incorporated into phospholipids, especially in rats on a diet of blackcurrant seed oil.

Authors+Show Affiliations

Unité de Recherche de Nutrition cellulaire et Métabolique, Université de Bourgogne, Dijon, France.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1657182

Citation

Ulmann, L, et al. "Incorporation Into Liver Microsomal Lipids of Linoleic and Stearic Acids and of Their Respective Products of Delta 6 and Delta 9 Desaturation, Gamma-linolenic and Oleic Acids: Effect of Age and of Blackcurrant Seed Oil." Biochimica Et Biophysica Acta, vol. 1086, no. 2, 1991, pp. 230-6.
Ulmann L, Poisson JP, Blond JP, et al. Incorporation into liver microsomal lipids of linoleic and stearic acids and of their respective products of delta 6 and delta 9 desaturation, gamma-linolenic and oleic acids: effect of age and of blackcurrant seed oil. Biochim Biophys Acta. 1991;1086(2):230-6.
Ulmann, L., Poisson, J. P., Blond, J. P., & Bézard, J. (1991). Incorporation into liver microsomal lipids of linoleic and stearic acids and of their respective products of delta 6 and delta 9 desaturation, gamma-linolenic and oleic acids: effect of age and of blackcurrant seed oil. Biochimica Et Biophysica Acta, 1086(2), 230-6.
Ulmann L, et al. Incorporation Into Liver Microsomal Lipids of Linoleic and Stearic Acids and of Their Respective Products of Delta 6 and Delta 9 Desaturation, Gamma-linolenic and Oleic Acids: Effect of Age and of Blackcurrant Seed Oil. Biochim Biophys Acta. 1991 Nov 5;1086(2):230-6. PubMed PMID: 1657182.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incorporation into liver microsomal lipids of linoleic and stearic acids and of their respective products of delta 6 and delta 9 desaturation, gamma-linolenic and oleic acids: effect of age and of blackcurrant seed oil. AU - Ulmann,L, AU - Poisson,J P, AU - Blond,J P, AU - Bézard,J, PY - 1991/11/5/pubmed PY - 1991/11/5/medline PY - 1991/11/5/entrez SP - 230 EP - 6 JF - Biochimica et biophysica acta JO - Biochim Biophys Acta VL - 1086 IS - 2 N2 - The incorporation of [1-14C]linoleic and [1-14C]stearic acid and of their delta 6 and delta 9 desaturation products (gamma-linolenic and oleic acids, respectively) into different classes of lipids was studied in liver microsomes of rats in function of the diet (blackcurrant seed oil diet, containing gamma-linolenic acid, versus control diet) and in function of age (3, 6 and 9 months). After delta 6 desaturation, total radioactivity was distributed between phospholipids, especially phosphatidylcholine, and neutral lipids. The desaturation product, gamma-linolenic acid, was totally recovered in the phospholipid fraction. Blackcurrant seed oil, which decreased the rate of delta 6 desaturation in 6- and 9-month-old rats, also decreased the incorporation of radioactivity in total phospholipids, especially in phosphatidylcholine. At 6 months of age, after delta 9 desaturation, the majority of radioactivity was recovered in neutral lipids principally as oleic acid, the desaturation product. The precursor, stearic acid, was highly incorporated into phospholipids, especially in rats on a diet of blackcurrant seed oil. SN - 0006-3002 UR - https://www.unboundmedicine.com/medline/citation/1657182/Incorporation_into_liver_microsomal_lipids_of_linoleic_and_stearic_acids_and_of_their_respective_products_of_delta_6_and_delta_9_desaturation_gamma_linolenic_and_oleic_acids:_effect_of_age_and_of_blackcurrant_seed_oil_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0005-2760(91)90012-7 DB - PRIME DP - Unbound Medicine ER -