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[Recombinant viruses of poultry as vector vaccines against fowl plague].
Berl Munch Tierarztl Wochenschr. 2006 Mar-Apr; 119(3-4):160-6.BM

Abstract

To help in the control of fowl plague caused by highly pathogenic avian influenza A viruses of hemagglutinin (HA) subtypes H5 and H7 several vaccines have been developed. A prophylactic immunization of poultry with inactivated influenza viruses in non-endemic situations is questionable, however, due to the impairment of serological identification of field virus-infected animals which hinders elimination of the infectious agent from the population. This problem might be overcome by the use of genetically engineered marker vaccines which contain only the protective influenza virus hemagglutinin. Infected animals could then be unambiguously identified by their serum antibodies against other influenza virus proteins, e.g. neuraminidase or nucleoprotein. For such a use, purified HA or HA-expressing DNA vaccines are conceivable. Economically advantageous and easier to apply are modified live virus vaccines in use against other poultry diseases, which have been modified to express influenza virus HA. So far, recombinant HA-expressing fowlpox virus (FPV) as well as infectious laryngotracheitis and Newcastle disease viruses have been asssessed in animal experiments. An H5-expressing FPV recombinant is already in use in Central America and Southeast Asia but without accompanying marker diagnostics. Advantages and disadvantages of the different viral vectors are discussed.

Authors+Show Affiliations

Fuchs W
Institut für Molekularbiologie, Friedrich-Loeffler-Institut, Bundesforschungsinstitut für Tiergesundheit, Greifswald-Insel Riems. Walter.Fuchs@fli.bund.de
Veits J
No affiliation info available
Mettenleiter TC
No affiliation info available

MeSH

AnimalsBirdsFowlpox virusGenetic VectorsHerpesvirus 1, GallidInfluenza A virusInfluenza VaccinesInfluenza in BirdsPoultryVaccinationVaccines, AttenuatedVaccines, MarkerVaccines, SyntheticVirus Diseases

Pub Type(s)

English Abstract
Journal Article
Review

Language

ger

PubMed ID

16573206

Citation

Fuchs, Walter, et al. "[Recombinant Viruses of Poultry as Vector Vaccines Against Fowl Plague]." Berliner Und Munchener Tierarztliche Wochenschrift, vol. 119, no. 3-4, 2006, pp. 160-6.
Fuchs W, Veits J, Mettenleiter TC. [Recombinant viruses of poultry as vector vaccines against fowl plague]. Berl Munch Tierarztl Wochenschr. 2006;119(3-4):160-6.
Fuchs, W., Veits, J., & Mettenleiter, T. C. (2006). [Recombinant viruses of poultry as vector vaccines against fowl plague]. Berliner Und Munchener Tierarztliche Wochenschrift, 119(3-4), 160-6.
Fuchs W, Veits J, Mettenleiter TC. [Recombinant Viruses of Poultry as Vector Vaccines Against Fowl Plague]. Berl Munch Tierarztl Wochenschr. 2006 Mar-Apr;119(3-4):160-6. PubMed PMID: 16573206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Recombinant viruses of poultry as vector vaccines against fowl plague]. AU - Fuchs,Walter, AU - Veits,Jutta, AU - Mettenleiter,Thomas C, PY - 2006/4/1/pubmed PY - 2007/5/26/medline PY - 2006/4/1/entrez SP - 160 EP - 6 JF - Berliner und Munchener tierarztliche Wochenschrift JO - Berl Munch Tierarztl Wochenschr VL - 119 IS - 3-4 N2 - To help in the control of fowl plague caused by highly pathogenic avian influenza A viruses of hemagglutinin (HA) subtypes H5 and H7 several vaccines have been developed. A prophylactic immunization of poultry with inactivated influenza viruses in non-endemic situations is questionable, however, due to the impairment of serological identification of field virus-infected animals which hinders elimination of the infectious agent from the population. This problem might be overcome by the use of genetically engineered marker vaccines which contain only the protective influenza virus hemagglutinin. Infected animals could then be unambiguously identified by their serum antibodies against other influenza virus proteins, e.g. neuraminidase or nucleoprotein. For such a use, purified HA or HA-expressing DNA vaccines are conceivable. Economically advantageous and easier to apply are modified live virus vaccines in use against other poultry diseases, which have been modified to express influenza virus HA. So far, recombinant HA-expressing fowlpox virus (FPV) as well as infectious laryngotracheitis and Newcastle disease viruses have been asssessed in animal experiments. An H5-expressing FPV recombinant is already in use in Central America and Southeast Asia but without accompanying marker diagnostics. Advantages and disadvantages of the different viral vectors are discussed. SN - 0005-9366 UR - https://www.unboundmedicine.com/medline/citation/16573206/[Recombinant_viruses_of_poultry_as_vector_vaccines_against_fowl_plague]_ DB - PRIME DP - Unbound Medicine ER -