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Is MELD score sufficient to predict not only death on waiting list, but also post-transplant survival?
Transpl Int. 2006 Apr; 19(4):275-81.TI

Abstract

Model for end-stage liver disease (MELD) score has emerged as a useful tool in predicting mortality in patients awaiting liver transplantation. There is still, however, discussion as to whether further parameters could improve the sensitivity and specificity of the MELD score. From 1997 to 2003, 621 adult patients with end-stage liver disease were listed for orthotopic liver transplantation (OLT). Patients suffering from hepatoma were excluded from analysis (113 patients). The MELD score was investigated at the time of listing (MELD ON) and of coming off the list (MELD OFF). Patients who died while on the waiting list showed a significant increase in their MELD score during the waiting time (MELD ON: 21 +/- 7 vs. MELD OFF: 28 +/- 9) as well as a significantly higher MELD ON compared with patients who were transplanted (MELD ON: 16 +/- 5 vs. MELD OFF: 17 +/- 7) or removed from the waiting list (MELD ON: 16 +/- 6 vs. MELD OFF: 12 +/- 3). Multivariate analysis identified MELD ON, ascites and recurrent infection as independent risk factors for death on the waiting list (P < 0.01). MELD score was not identified as a predictor for the post-transplant survival rate. MELD score is a strong predictor for death on the waiting list, but refractory ascites and recurrent infection are independent risk factors, too.

Authors+Show Affiliations

Department of Transplant Surgery, Medical University Vienna, Austria. gerd.siberhumer@meduniwien.ac.atNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16573542

Citation

Silberhumer, Gerd R., et al. "Is MELD Score Sufficient to Predict Not Only Death On Waiting List, but Also Post-transplant Survival?" Transplant International : Official Journal of the European Society for Organ Transplantation, vol. 19, no. 4, 2006, pp. 275-81.
Silberhumer GR, Hetz H, Rasoul-Rockenschaub S, et al. Is MELD score sufficient to predict not only death on waiting list, but also post-transplant survival? Transpl Int. 2006;19(4):275-81.
Silberhumer, G. R., Hetz, H., Rasoul-Rockenschaub, S., Peck-Radosavljevic, M., Soliman, T., Steininger, R., Muehlbacher, F., & Berlakovich, G. A. (2006). Is MELD score sufficient to predict not only death on waiting list, but also post-transplant survival? Transplant International : Official Journal of the European Society for Organ Transplantation, 19(4), 275-81.
Silberhumer GR, et al. Is MELD Score Sufficient to Predict Not Only Death On Waiting List, but Also Post-transplant Survival. Transpl Int. 2006;19(4):275-81. PubMed PMID: 16573542.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is MELD score sufficient to predict not only death on waiting list, but also post-transplant survival? AU - Silberhumer,Gerd R, AU - Hetz,Hubert, AU - Rasoul-Rockenschaub,Susanne, AU - Peck-Radosavljevic,Markus, AU - Soliman,Thomas, AU - Steininger,Rudolf, AU - Muehlbacher,Ferdinand, AU - Berlakovich,Gabriela A, PY - 2006/4/1/pubmed PY - 2006/6/24/medline PY - 2006/4/1/entrez SP - 275 EP - 81 JF - Transplant international : official journal of the European Society for Organ Transplantation JO - Transpl Int VL - 19 IS - 4 N2 - Model for end-stage liver disease (MELD) score has emerged as a useful tool in predicting mortality in patients awaiting liver transplantation. There is still, however, discussion as to whether further parameters could improve the sensitivity and specificity of the MELD score. From 1997 to 2003, 621 adult patients with end-stage liver disease were listed for orthotopic liver transplantation (OLT). Patients suffering from hepatoma were excluded from analysis (113 patients). The MELD score was investigated at the time of listing (MELD ON) and of coming off the list (MELD OFF). Patients who died while on the waiting list showed a significant increase in their MELD score during the waiting time (MELD ON: 21 +/- 7 vs. MELD OFF: 28 +/- 9) as well as a significantly higher MELD ON compared with patients who were transplanted (MELD ON: 16 +/- 5 vs. MELD OFF: 17 +/- 7) or removed from the waiting list (MELD ON: 16 +/- 6 vs. MELD OFF: 12 +/- 3). Multivariate analysis identified MELD ON, ascites and recurrent infection as independent risk factors for death on the waiting list (P < 0.01). MELD score was not identified as a predictor for the post-transplant survival rate. MELD score is a strong predictor for death on the waiting list, but refractory ascites and recurrent infection are independent risk factors, too. SN - 0934-0874 UR - https://www.unboundmedicine.com/medline/citation/16573542/Is_MELD_score_sufficient_to_predict_not_only_death_on_waiting_list_but_also_post_transplant_survival L2 - https://doi.org/10.1111/j.1432-2277.2006.00250.x DB - PRIME DP - Unbound Medicine ER -