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Cord blood transplantation for acute myelogenous leukemia using a conditioning regimen consisting of granulocyte colony-stimulating factor-combined high-dose cytarabine, fludarabine, and total body irradiation.
Eur J Haematol. 2006 Jul; 77(1):46-50.EJ

Abstract

The cytotoxic effect of cytarabine (Ara-C) on myeloid leukemic cells is enhanced by concomitant use of granulocyte colony-stimulating factor (G-CSF) in vitro. The feasibility of a conditioning regimen consisting of G-CSF-combined 24 g/m2 Ara-C, 90 mg/m2 fludarabine, and 12 Gy total body irradiation was studied for five patients with acute myelogenous leukemia in cord blood transplantation (CBT). Graft vs. host disease (GVHD) prophylaxis consisted of cyclosporine and methotrexate. After the conditioning regimen, 2.48 x 10(7)/kg (2.28-3.53) of cord blood nucleated cells was infused. Neutrophil counts consistently >0.5 x 10(9)/L was achieved 24 d (22-32) after CBT. Grade I stomatitis and gastrointestinal toxicities occurred in all patients. Grades I and II acute GVHD occurred in one and four patients, respectively, which resolved without steroid therapy. Sepsis and aspergillosis occurred in two and one patients, respectively. All patients were alive without leukemia relapse at a follow up of 15 months (12-43) after CBT. This conditioning regimen could avoid the toxicities of high-dose cyclophosphamide but might enhance the cytotoxic effect of Ara-C. Large-scale studies will be needed to determine the efficacy and safety of the conditioning regimen in CBT.

Authors+Show Affiliations

Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. atomonar@ims.u-tokyo.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16573743

Citation

Tomonari, Akira, et al. "Cord Blood Transplantation for Acute Myelogenous Leukemia Using a Conditioning Regimen Consisting of Granulocyte Colony-stimulating Factor-combined High-dose Cytarabine, Fludarabine, and Total Body Irradiation." European Journal of Haematology, vol. 77, no. 1, 2006, pp. 46-50.
Tomonari A, Takahashi S, Ooi J, et al. Cord blood transplantation for acute myelogenous leukemia using a conditioning regimen consisting of granulocyte colony-stimulating factor-combined high-dose cytarabine, fludarabine, and total body irradiation. Eur J Haematol. 2006;77(1):46-50.
Tomonari, A., Takahashi, S., Ooi, J., Nakaoka, T., Takasugi, K., Uchiyama, M., Tsukada, N., Konuma, T., Iseki, T., Tojo, A., & Asano, S. (2006). Cord blood transplantation for acute myelogenous leukemia using a conditioning regimen consisting of granulocyte colony-stimulating factor-combined high-dose cytarabine, fludarabine, and total body irradiation. European Journal of Haematology, 77(1), 46-50.
Tomonari A, et al. Cord Blood Transplantation for Acute Myelogenous Leukemia Using a Conditioning Regimen Consisting of Granulocyte Colony-stimulating Factor-combined High-dose Cytarabine, Fludarabine, and Total Body Irradiation. Eur J Haematol. 2006;77(1):46-50. PubMed PMID: 16573743.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cord blood transplantation for acute myelogenous leukemia using a conditioning regimen consisting of granulocyte colony-stimulating factor-combined high-dose cytarabine, fludarabine, and total body irradiation. AU - Tomonari,Akira, AU - Takahashi,Satoshi, AU - Ooi,Jun, AU - Nakaoka,Takashi, AU - Takasugi,Kashiya, AU - Uchiyama,Michihiro, AU - Tsukada,Nobuhiro, AU - Konuma,Takaaki, AU - Iseki,Tohru, AU - Tojo,Arinobu, AU - Asano,Shigetaka, Y1 - 2006/03/27/ PY - 2006/4/1/pubmed PY - 2006/8/25/medline PY - 2006/4/1/entrez SP - 46 EP - 50 JF - European journal of haematology JO - Eur J Haematol VL - 77 IS - 1 N2 - The cytotoxic effect of cytarabine (Ara-C) on myeloid leukemic cells is enhanced by concomitant use of granulocyte colony-stimulating factor (G-CSF) in vitro. The feasibility of a conditioning regimen consisting of G-CSF-combined 24 g/m2 Ara-C, 90 mg/m2 fludarabine, and 12 Gy total body irradiation was studied for five patients with acute myelogenous leukemia in cord blood transplantation (CBT). Graft vs. host disease (GVHD) prophylaxis consisted of cyclosporine and methotrexate. After the conditioning regimen, 2.48 x 10(7)/kg (2.28-3.53) of cord blood nucleated cells was infused. Neutrophil counts consistently >0.5 x 10(9)/L was achieved 24 d (22-32) after CBT. Grade I stomatitis and gastrointestinal toxicities occurred in all patients. Grades I and II acute GVHD occurred in one and four patients, respectively, which resolved without steroid therapy. Sepsis and aspergillosis occurred in two and one patients, respectively. All patients were alive without leukemia relapse at a follow up of 15 months (12-43) after CBT. This conditioning regimen could avoid the toxicities of high-dose cyclophosphamide but might enhance the cytotoxic effect of Ara-C. Large-scale studies will be needed to determine the efficacy and safety of the conditioning regimen in CBT. SN - 0902-4441 UR - https://www.unboundmedicine.com/medline/citation/16573743/Cord_blood_transplantation_for_acute_myelogenous_leukemia_using_a_conditioning_regimen_consisting_of_granulocyte_colony_stimulating_factor_combined_high_dose_cytarabine_fludarabine_and_total_body_irradiation_ L2 - https://doi.org/10.1111/j.0902-4441.2006.t01-1-EJH2608.x DB - PRIME DP - Unbound Medicine ER -