Tags

Type your tag names separated by a space and hit enter

Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer beta-amyloid pathology.
J Inorg Biochem. 2006 May; 100(5-6):952-62.JI

Abstract

The incidence of Alzheimer's disease (AD) is greater in women than men at any age, as is the development of amyloid pathology in several transgenic mouse models of AD. Due to the involvement of metals in AD pathogenesis, variations between the sexes in metal metabolism may contribute to the sex difference in AD risk. In this study, we investigated sex differences in brain metal levels across the lifespan in mice of two different background strains, as well as in mice overexpressing the human amyloid precursor protein (APP) and amyloid-beta protein (Abeta). We demonstrate consistently lower Cu and higher Mn levels in females compared with males at any age studied. The sex differences in Cu and Mn levels are independent of APP/Abeta expression. AD brain exhibits decreased Cu and increased Mn levels, as do transgenic mice overexpressing APP or Abeta. The age-dependent elevations of Cu, Fe and Co levels were found to be significantly greater in mice of B6/SJL background compared with B6/DBA. If depleting Cu and/or rising Mn levels contribute to AD pathogenesis, natural sex differences in these brain metal levels may contribute to the increased propensity of females to develop AD.

Authors+Show Affiliations

Department of Pathology, The University of Melbourne, Vic. 3010, Australia. christa.maynard@cmb.ki.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16574231

Citation

Maynard, Christa J., et al. "Gender and Genetic Background Effects On Brain Metal Levels in APP Transgenic and Normal Mice: Implications for Alzheimer Beta-amyloid Pathology." Journal of Inorganic Biochemistry, vol. 100, no. 5-6, 2006, pp. 952-62.
Maynard CJ, Cappai R, Volitakis I, et al. Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer beta-amyloid pathology. J Inorg Biochem. 2006;100(5-6):952-62.
Maynard, C. J., Cappai, R., Volitakis, I., Cherny, R. A., Masters, C. L., Li, Q. X., & Bush, A. I. (2006). Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer beta-amyloid pathology. Journal of Inorganic Biochemistry, 100(5-6), 952-62.
Maynard CJ, et al. Gender and Genetic Background Effects On Brain Metal Levels in APP Transgenic and Normal Mice: Implications for Alzheimer Beta-amyloid Pathology. J Inorg Biochem. 2006;100(5-6):952-62. PubMed PMID: 16574231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer beta-amyloid pathology. AU - Maynard,Christa J, AU - Cappai,Roberto, AU - Volitakis,Irene, AU - Cherny,Robert A, AU - Masters,Colin L, AU - Li,Qiao-Xin, AU - Bush,Ashley I, Y1 - 2006/03/06/ PY - 2005/08/31/received PY - 2006/02/12/revised PY - 2006/02/13/accepted PY - 2006/4/1/pubmed PY - 2006/6/29/medline PY - 2006/4/1/entrez SP - 952 EP - 62 JF - Journal of inorganic biochemistry JO - J. Inorg. Biochem. VL - 100 IS - 5-6 N2 - The incidence of Alzheimer's disease (AD) is greater in women than men at any age, as is the development of amyloid pathology in several transgenic mouse models of AD. Due to the involvement of metals in AD pathogenesis, variations between the sexes in metal metabolism may contribute to the sex difference in AD risk. In this study, we investigated sex differences in brain metal levels across the lifespan in mice of two different background strains, as well as in mice overexpressing the human amyloid precursor protein (APP) and amyloid-beta protein (Abeta). We demonstrate consistently lower Cu and higher Mn levels in females compared with males at any age studied. The sex differences in Cu and Mn levels are independent of APP/Abeta expression. AD brain exhibits decreased Cu and increased Mn levels, as do transgenic mice overexpressing APP or Abeta. The age-dependent elevations of Cu, Fe and Co levels were found to be significantly greater in mice of B6/SJL background compared with B6/DBA. If depleting Cu and/or rising Mn levels contribute to AD pathogenesis, natural sex differences in these brain metal levels may contribute to the increased propensity of females to develop AD. SN - 0162-0134 UR - https://www.unboundmedicine.com/medline/citation/16574231/Gender_and_genetic_background_effects_on_brain_metal_levels_in_APP_transgenic_and_normal_mice:_implications_for_Alzheimer_beta_amyloid_pathology_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0162-0134(06)00067-5 DB - PRIME DP - Unbound Medicine ER -