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Coeliac disease and risk of renal disease-a general population cohort study.
Nephrol Dial Transplant 2006; 21(7):1809-15ND

Abstract

BACKGROUND

Coeliac disease (CD) may be a risk factor for renal disease.

METHODS

We investigated the risk of any form of glomerulonephritis (GN) (acute, chronic and non-specified), chronic glomerulonephritis (CGN) and renal replacement therapy including dialysis treatment and kidney transplantation (KT) in patients with CD in a general population-based cohort study. We used Cox regression to assess the risk of renal disease in 14,336 patients who had received a diagnosis of CD (1964-2003) and 69,875 reference individuals matched for age, calendar year, sex and county. Patients were identified using the Swedish Hospital Discharge Registry. Follow-up began 1 year after study entry.

RESULTS

CD was associated with an increased risk of any form of GN (hazard ratio (HR) = 1.64; 95% confidence intervals (CI) = 1.01-2.66; P = 0.046; 89 events), CGN (HR = 2.65; 95% CI = 1.34-5.24; P = 0.005; 39 events), dialysis (HR = 3.48; 95% CI = 2.26-5.37; P < 0.001; 102 positive events) and KT (HR = 3.15; 95% CI = 1.29-7.71; P = 0.012; 22 events).

CONCLUSION

We suggest that immune characteristics associated with CD increase the risk of chronic renal disease. Individuals with CD may also be at a moderately increased risk of any form of GN.

Authors+Show Affiliations

Department of Paediatrics, Orebro University Hospital, Sweden. jonasludvigsson@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16574681

Citation

Ludvigsson, Jonas F., et al. "Coeliac Disease and Risk of Renal Disease-a General Population Cohort Study." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, vol. 21, no. 7, 2006, pp. 1809-15.
Ludvigsson JF, Montgomery SM, Olén O, et al. Coeliac disease and risk of renal disease-a general population cohort study. Nephrol Dial Transplant. 2006;21(7):1809-15.
Ludvigsson, J. F., Montgomery, S. M., Olén, O., Ekbom, A., Ludvigsson, J., & Fored, M. (2006). Coeliac disease and risk of renal disease-a general population cohort study. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 21(7), pp. 1809-15.
Ludvigsson JF, et al. Coeliac Disease and Risk of Renal Disease-a General Population Cohort Study. Nephrol Dial Transplant. 2006;21(7):1809-15. PubMed PMID: 16574681.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coeliac disease and risk of renal disease-a general population cohort study. AU - Ludvigsson,Jonas F, AU - Montgomery,Scott M, AU - Olén,Ola, AU - Ekbom,Anders, AU - Ludvigsson,Johnny, AU - Fored,Michael, Y1 - 2006/03/30/ PY - 2006/4/1/pubmed PY - 2007/2/3/medline PY - 2006/4/1/entrez SP - 1809 EP - 15 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol. Dial. Transplant. VL - 21 IS - 7 N2 - BACKGROUND: Coeliac disease (CD) may be a risk factor for renal disease. METHODS: We investigated the risk of any form of glomerulonephritis (GN) (acute, chronic and non-specified), chronic glomerulonephritis (CGN) and renal replacement therapy including dialysis treatment and kidney transplantation (KT) in patients with CD in a general population-based cohort study. We used Cox regression to assess the risk of renal disease in 14,336 patients who had received a diagnosis of CD (1964-2003) and 69,875 reference individuals matched for age, calendar year, sex and county. Patients were identified using the Swedish Hospital Discharge Registry. Follow-up began 1 year after study entry. RESULTS: CD was associated with an increased risk of any form of GN (hazard ratio (HR) = 1.64; 95% confidence intervals (CI) = 1.01-2.66; P = 0.046; 89 events), CGN (HR = 2.65; 95% CI = 1.34-5.24; P = 0.005; 39 events), dialysis (HR = 3.48; 95% CI = 2.26-5.37; P < 0.001; 102 positive events) and KT (HR = 3.15; 95% CI = 1.29-7.71; P = 0.012; 22 events). CONCLUSION: We suggest that immune characteristics associated with CD increase the risk of chronic renal disease. Individuals with CD may also be at a moderately increased risk of any form of GN. SN - 0931-0509 UR - https://www.unboundmedicine.com/medline/citation/16574681/Coeliac_disease_and_risk_of_renal_disease_a_general_population_cohort_study_ L2 - https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/gfl117 DB - PRIME DP - Unbound Medicine ER -