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Characteristics and treatment of hepatic rupture caused by HELLP syndrome.
Am J Obstet Gynecol. 2006 Jul; 195(1):129-33.AJ

Abstract

OBJECTIVE

The purpose of this study was to review the management of hepatic rupture caused by HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome and to assess maternal and perinatal outcomes of these cases.

STUDY DESIGN

A retrospective study of HELLP syndrome cases that were complicated by hepatic rupture was conducted.

RESULTS

Ten cases of hepatic rupture were identified. The median maternal age was 42.5 +/- 5.9 years (median +/- SD), and the median gestational age at delivery was 35.5 +/- 4.9 weeks. The most frequent signs and symptoms of hepatic rupture were the sudden onset of abdominal pain, acute anemia, and hypotension. Laboratory findings included low platelet count and increased hepatic enzymes. Surgery was performed in 9 cases. One case was treated nonsurgically. The maternal mortality rate was 10%, and the perinatal mortality rate was 80%.

CONCLUSION

A combination of surgical treatment with hepatic artery ligation and omental patching with supportive measures was effective in decreasing the mortality rate in hepatic rupture caused by HELLP syndrome.

Authors+Show Affiliations

Department of Gynecology and Obstetrics, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16579935

Citation

Araujo, Ana C P F., et al. "Characteristics and Treatment of Hepatic Rupture Caused By HELLP Syndrome." American Journal of Obstetrics and Gynecology, vol. 195, no. 1, 2006, pp. 129-33.
Araujo AC, Leao MD, Nobrega MH, et al. Characteristics and treatment of hepatic rupture caused by HELLP syndrome. Am J Obstet Gynecol. 2006;195(1):129-33.
Araujo, A. C., Leao, M. D., Nobrega, M. H., Bezerra, P. F., Pereira, F. V., Dantas, E. M., Azevedo, G. D., & Jeronimo, S. M. (2006). Characteristics and treatment of hepatic rupture caused by HELLP syndrome. American Journal of Obstetrics and Gynecology, 195(1), 129-33.
Araujo AC, et al. Characteristics and Treatment of Hepatic Rupture Caused By HELLP Syndrome. Am J Obstet Gynecol. 2006;195(1):129-33. PubMed PMID: 16579935.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics and treatment of hepatic rupture caused by HELLP syndrome. AU - Araujo,Ana C P F, AU - Leao,Marcos D, AU - Nobrega,Maria H, AU - Bezerra,Patricia F M, AU - Pereira,Flavio V M, AU - Dantas,Edailna M M, AU - Azevedo,George D, AU - Jeronimo,Selma M B, Y1 - 2006/03/30/ PY - 2005/09/09/received PY - 2005/11/22/revised PY - 2006/01/10/accepted PY - 2006/4/4/pubmed PY - 2006/7/25/medline PY - 2006/4/4/entrez SP - 129 EP - 33 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 195 IS - 1 N2 - OBJECTIVE: The purpose of this study was to review the management of hepatic rupture caused by HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome and to assess maternal and perinatal outcomes of these cases. STUDY DESIGN: A retrospective study of HELLP syndrome cases that were complicated by hepatic rupture was conducted. RESULTS: Ten cases of hepatic rupture were identified. The median maternal age was 42.5 +/- 5.9 years (median +/- SD), and the median gestational age at delivery was 35.5 +/- 4.9 weeks. The most frequent signs and symptoms of hepatic rupture were the sudden onset of abdominal pain, acute anemia, and hypotension. Laboratory findings included low platelet count and increased hepatic enzymes. Surgery was performed in 9 cases. One case was treated nonsurgically. The maternal mortality rate was 10%, and the perinatal mortality rate was 80%. CONCLUSION: A combination of surgical treatment with hepatic artery ligation and omental patching with supportive measures was effective in decreasing the mortality rate in hepatic rupture caused by HELLP syndrome. SN - 1097-6868 UR - https://www.unboundmedicine.com/medline/citation/16579935/Characteristics_and_treatment_of_hepatic_rupture_caused_by_HELLP_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9378(06)00058-5 DB - PRIME DP - Unbound Medicine ER -