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Serum soluble leptin receptor levels and free leptin index in women with polycystic ovary syndrome: relationship to insulin resistance and androgens.
Fertil Steril 2006; 85(5):1441-7FS

Abstract

OBJECTIVE

To evaluate levels of soluble receptor (sOB-R) and free leptin in women with polycystic ovarian syndrome (PCOS) and note any relationships with insulin resistance, adiposity, and androgens. Leptin is an adipokine that circulates in a free form and bound to an sOB-R. Only free leptin is biologically active.

DESIGN

Prospective, case-control study.

SETTING

University-based reproductive endocrinology practice.

PATIENT(S)

Forty women with PCOS and severe insulin resistance and 15 body mass index (BMI)-matched ovulatory controls.

INTERVENTION(S)

Measurements of serum insulin, leptin, sOB-R at fasting and during a standard oral glucose tolerance test (OGTT), and measurements before and after treatment with rosiglitazone.

MAIN OUTCOME MEASURE(S)

Fasting glucose, insulin, leptin, sOB-R, T, and DHEAS levels in women with PCOS and controls were measured to investigate the relationship of sOB-R and the free leptin index (FLI) to insulin, adipocity, and androgens and to investigate the effect of acute hyperinsulinemia during OGTT and the effect of improvement of insulin resistance with rosiglitazone on the leptin system. FLI was calculated by dividing leptin levels by sOB-R.

RESULT(S)

Total leptin and FLI correlated significantly with BMI in both patients with PCOS and in controls. There was a significant negative correlation between DHEAS and sOB-R in PCOS. Leptin, sOB-R, and FLI were not significantly different in the two groups, and neither sOB-R nor FLI correlated with insulin or glucose levels. The sOB-R levels increased significantly 3 hours after oral glucose ingestion, resulting in a significant decline in FLI.

CONCLUSION(S)

[1] Adiposity rather than insulin resistance appears to be the main determinant of leptin levels and FLI. [2] Acute increase in insulin levels during OGTT is associated with an increase in levels of sOB-R. [3] DHEAS may play a role in leptin bioavailability by modulating sOB-R levels.

Authors+Show Affiliations

Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas 77555-0587, USA.

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

16579998

Citation

Sepilian, Vicken P., et al. "Serum Soluble Leptin Receptor Levels and Free Leptin Index in Women With Polycystic Ovary Syndrome: Relationship to Insulin Resistance and Androgens." Fertility and Sterility, vol. 85, no. 5, 2006, pp. 1441-7.
Sepilian VP, Crochet JR, Nagamani M. Serum soluble leptin receptor levels and free leptin index in women with polycystic ovary syndrome: relationship to insulin resistance and androgens. Fertil Steril. 2006;85(5):1441-7.
Sepilian, V. P., Crochet, J. R., & Nagamani, M. (2006). Serum soluble leptin receptor levels and free leptin index in women with polycystic ovary syndrome: relationship to insulin resistance and androgens. Fertility and Sterility, 85(5), pp. 1441-7.
Sepilian VP, Crochet JR, Nagamani M. Serum Soluble Leptin Receptor Levels and Free Leptin Index in Women With Polycystic Ovary Syndrome: Relationship to Insulin Resistance and Androgens. Fertil Steril. 2006;85(5):1441-7. PubMed PMID: 16579998.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum soluble leptin receptor levels and free leptin index in women with polycystic ovary syndrome: relationship to insulin resistance and androgens. AU - Sepilian,Vicken P, AU - Crochet,John R, AU - Nagamani,Manubai, Y1 - 2006/03/31/ PY - 2005/07/10/received PY - 2005/10/11/revised PY - 2005/10/11/accepted PY - 2006/4/4/pubmed PY - 2006/5/24/medline PY - 2006/4/4/entrez SP - 1441 EP - 7 JF - Fertility and sterility JO - Fertil. Steril. VL - 85 IS - 5 N2 - OBJECTIVE: To evaluate levels of soluble receptor (sOB-R) and free leptin in women with polycystic ovarian syndrome (PCOS) and note any relationships with insulin resistance, adiposity, and androgens. Leptin is an adipokine that circulates in a free form and bound to an sOB-R. Only free leptin is biologically active. DESIGN: Prospective, case-control study. SETTING: University-based reproductive endocrinology practice. PATIENT(S): Forty women with PCOS and severe insulin resistance and 15 body mass index (BMI)-matched ovulatory controls. INTERVENTION(S): Measurements of serum insulin, leptin, sOB-R at fasting and during a standard oral glucose tolerance test (OGTT), and measurements before and after treatment with rosiglitazone. MAIN OUTCOME MEASURE(S): Fasting glucose, insulin, leptin, sOB-R, T, and DHEAS levels in women with PCOS and controls were measured to investigate the relationship of sOB-R and the free leptin index (FLI) to insulin, adipocity, and androgens and to investigate the effect of acute hyperinsulinemia during OGTT and the effect of improvement of insulin resistance with rosiglitazone on the leptin system. FLI was calculated by dividing leptin levels by sOB-R. RESULT(S): Total leptin and FLI correlated significantly with BMI in both patients with PCOS and in controls. There was a significant negative correlation between DHEAS and sOB-R in PCOS. Leptin, sOB-R, and FLI were not significantly different in the two groups, and neither sOB-R nor FLI correlated with insulin or glucose levels. The sOB-R levels increased significantly 3 hours after oral glucose ingestion, resulting in a significant decline in FLI. CONCLUSION(S): [1] Adiposity rather than insulin resistance appears to be the main determinant of leptin levels and FLI. [2] Acute increase in insulin levels during OGTT is associated with an increase in levels of sOB-R. [3] DHEAS may play a role in leptin bioavailability by modulating sOB-R levels. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/16579998/Serum_soluble_leptin_receptor_levels_and_free_leptin_index_in_women_with_polycystic_ovary_syndrome:_relationship_to_insulin_resistance_and_androgens_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(06)00080-X DB - PRIME DP - Unbound Medicine ER -