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A unified theory of central tolerance in the thymus.
Trends Immunol. 2006 May; 27(5):215-21.TI

Abstract

Non-deletional tolerance resulting in the generation of regulatory T cells within the thymus is a key mechanism for the establishment of immunological self-tolerance. How the high-affinity self-reactive regulatory T cells escape negative selection and what type of antigen-presenting cells positively select them within the thymus are unsolved questions. Previous studies suggest that thymic epithelial cells are crucial for the positive selection of regulatory T cells in thymus. A recent study from my group shows that a subset of dendritic cells (that have been "educated" by the thymic stromal lymphopoietin molecule produced by a thymic cell type known as Hassall's corpuscles) positively select regulatory T cells within the medulla of human thymus. Here, I discuss the implications and historical context of this new result and suggest that a subset of mature dendritic cells within the thymic medulla protects the medium- to high-affinity self-reactive T cells from negative deletion and induces their differentiation into regulatory T cells in the thymus.

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Authors+Show Affiliations

Liu YJ
Department of Immunology, and Center of Cancer Immunology Research, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA. jyliu@mdanderson.org

MeSH

AnimalsCD4-Positive T-LymphocytesCell MovementDendritic CellsHepatocyte Nuclear Factor 3-gammaHumansImmune ToleranceThymus Gland

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16580260

Citation

Liu, Yong-Jun. "A Unified Theory of Central Tolerance in the Thymus." Trends in Immunology, vol. 27, no. 5, 2006, pp. 215-21.
Liu YJ. A unified theory of central tolerance in the thymus. Trends Immunol. 2006;27(5):215-21.
Liu, Y. J. (2006). A unified theory of central tolerance in the thymus. Trends in Immunology, 27(5), 215-21.
Liu YJ. A Unified Theory of Central Tolerance in the Thymus. Trends Immunol. 2006;27(5):215-21. PubMed PMID: 16580260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A unified theory of central tolerance in the thymus. A1 - Liu,Yong-Jun, Y1 - 2006/03/30/ PY - 2006/01/14/received PY - 2006/02/20/revised PY - 2006/03/17/accepted PY - 2006/4/4/pubmed PY - 2006/12/9/medline PY - 2006/4/4/entrez SP - 215 EP - 21 JF - Trends in immunology JO - Trends Immunol VL - 27 IS - 5 N2 - Non-deletional tolerance resulting in the generation of regulatory T cells within the thymus is a key mechanism for the establishment of immunological self-tolerance. How the high-affinity self-reactive regulatory T cells escape negative selection and what type of antigen-presenting cells positively select them within the thymus are unsolved questions. Previous studies suggest that thymic epithelial cells are crucial for the positive selection of regulatory T cells in thymus. A recent study from my group shows that a subset of dendritic cells (that have been "educated" by the thymic stromal lymphopoietin molecule produced by a thymic cell type known as Hassall's corpuscles) positively select regulatory T cells within the medulla of human thymus. Here, I discuss the implications and historical context of this new result and suggest that a subset of mature dendritic cells within the thymic medulla protects the medium- to high-affinity self-reactive T cells from negative deletion and induces their differentiation into regulatory T cells in the thymus. SN - 1471-4906 UR - https://www.unboundmedicine.com/medline/citation/16580260/A_unified_theory_of_central_tolerance_in_the_thymus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1471-4906(06)00091-3 DB - PRIME DP - Unbound Medicine ER -