Tags

Type your tag names separated by a space and hit enter

Pregnancy outcome in infertile patients with polycystic ovary syndrome who were treated with metformin.
Fertil Steril 2006; 85(4):1002-9FS

Abstract

OBJECTIVE

To analyze pregnancy complications and outcome in patients with polycystic ovary syndrome (PCOS) treated with metformin.

DESIGN

Single center retrospective case analysis.

SETTING

Private regional nonurban referral subspecialty practice.

PATIENT(S)

After 7 months of average metformin use, 188 patients with PCOS (average infertility: 27 months) achieved 237 pregnancies.

INTERVENTION(S)

Of pregnancies established, metformin alone was used before conception in 124/237 (52%), oral fertility agents (CC or letrozole) in 81 (34%), gonadotropin therapy in 7 (3.0%), assisted reproduction in 17 (7.2%), and other fertility-promoting regimens in 8 (3.4%).

MAIN OUTCOME MEASURE(S)

Analysis of prepregnancy health parameters (weight, blood pressure, glucose tolerance, fasting and stimulated insulin levels) and pregnancy outcomes (miscarriage, pregnancy length, hypertension, gestational diabetes, weight gain, birth weight, sex ratio, congenital malformations, and breastfeeding success).

RESULT(S)

Metformin appears to decrease the rate of spontaneous abortion. The co-morbidities of PCOS including obesity, insulin resistance, and glucose sensitivity served as indicators of increased risk for pregnancy complications, especially gestational diabetes. No increase in pregnancy-induced hypertension was evident. Prematurity was increased. Neither PCOS nor metformin use appears to increase the rate of congenital anomaly. PCOS did not affect lactation.

CONCLUSION(S)

PCOS or its co-morbidities are associated with poorer pregnancy outcome. Implications and interventions are discussed.

Authors+Show Affiliations

Center for Applied Reproductive Science, Johnson City, Tennessee 37604-6088, USA. thatcher@ivf-et.comNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16580387

Citation

Thatcher, Samuel S., and Elizabeth M. Jackson. "Pregnancy Outcome in Infertile Patients With Polycystic Ovary Syndrome Who Were Treated With Metformin." Fertility and Sterility, vol. 85, no. 4, 2006, pp. 1002-9.
Thatcher SS, Jackson EM. Pregnancy outcome in infertile patients with polycystic ovary syndrome who were treated with metformin. Fertil Steril. 2006;85(4):1002-9.
Thatcher, S. S., & Jackson, E. M. (2006). Pregnancy outcome in infertile patients with polycystic ovary syndrome who were treated with metformin. Fertility and Sterility, 85(4), pp. 1002-9.
Thatcher SS, Jackson EM. Pregnancy Outcome in Infertile Patients With Polycystic Ovary Syndrome Who Were Treated With Metformin. Fertil Steril. 2006;85(4):1002-9. PubMed PMID: 16580387.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pregnancy outcome in infertile patients with polycystic ovary syndrome who were treated with metformin. AU - Thatcher,Samuel S, AU - Jackson,Elizabeth M, Y1 - 2006/03/09/ PY - 2005/06/02/received PY - 2005/09/30/revised PY - 2005/09/30/accepted PY - 2006/4/4/pubmed PY - 2006/5/12/medline PY - 2006/4/4/entrez SP - 1002 EP - 9 JF - Fertility and sterility JO - Fertil. Steril. VL - 85 IS - 4 N2 - OBJECTIVE: To analyze pregnancy complications and outcome in patients with polycystic ovary syndrome (PCOS) treated with metformin. DESIGN: Single center retrospective case analysis. SETTING: Private regional nonurban referral subspecialty practice. PATIENT(S): After 7 months of average metformin use, 188 patients with PCOS (average infertility: 27 months) achieved 237 pregnancies. INTERVENTION(S): Of pregnancies established, metformin alone was used before conception in 124/237 (52%), oral fertility agents (CC or letrozole) in 81 (34%), gonadotropin therapy in 7 (3.0%), assisted reproduction in 17 (7.2%), and other fertility-promoting regimens in 8 (3.4%). MAIN OUTCOME MEASURE(S): Analysis of prepregnancy health parameters (weight, blood pressure, glucose tolerance, fasting and stimulated insulin levels) and pregnancy outcomes (miscarriage, pregnancy length, hypertension, gestational diabetes, weight gain, birth weight, sex ratio, congenital malformations, and breastfeeding success). RESULT(S): Metformin appears to decrease the rate of spontaneous abortion. The co-morbidities of PCOS including obesity, insulin resistance, and glucose sensitivity served as indicators of increased risk for pregnancy complications, especially gestational diabetes. No increase in pregnancy-induced hypertension was evident. Prematurity was increased. Neither PCOS nor metformin use appears to increase the rate of congenital anomaly. PCOS did not affect lactation. CONCLUSION(S): PCOS or its co-morbidities are associated with poorer pregnancy outcome. Implications and interventions are discussed. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/16580387/Pregnancy_outcome_in_infertile_patients_with_polycystic_ovary_syndrome_who_were_treated_with_metformin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(05)04212-3 DB - PRIME DP - Unbound Medicine ER -