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Genetic factors associated with gout and hyperuricemia.
Adv Chronic Kidney Dis 2006; 13(2):124-30AC

Abstract

Hyperuricemia and gout are common conditions that have long been known to have a heritable component. Obesity, diabetes, and chronic kidney failure are conditions with multifactorial inheritance that are associated with gout. In addition, social factors such as protein and alcohol intake affect serum uric acid levels. The current review discusses basic uric acid metabolism and the multigenetic inheritance of hyperuricemia. Several monogenic disorders affecting uric acid metabolism are reviewed. The genetics, pathophysiology, diagnosis, and treatment of familial juvenile hyperuricemic nephropathy/medullary cystic kidney disease, autosomal dominant disorders associated with hyperuricemia and progressive kidney failure, are described.

Authors+Show Affiliations

Department of Internal Medicine, Section on Nephrology, The Wake Forest University School of Medicine, Winston-Salem, NC 27157-1053, USA. ableyer@wfubmc.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

16580613

Citation

Bleyer, Anthony J., and Thomas C. Hart. "Genetic Factors Associated With Gout and Hyperuricemia." Advances in Chronic Kidney Disease, vol. 13, no. 2, 2006, pp. 124-30.
Bleyer AJ, Hart TC. Genetic factors associated with gout and hyperuricemia. Adv Chronic Kidney Dis. 2006;13(2):124-30.
Bleyer, A. J., & Hart, T. C. (2006). Genetic factors associated with gout and hyperuricemia. Advances in Chronic Kidney Disease, 13(2), pp. 124-30.
Bleyer AJ, Hart TC. Genetic Factors Associated With Gout and Hyperuricemia. Adv Chronic Kidney Dis. 2006;13(2):124-30. PubMed PMID: 16580613.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic factors associated with gout and hyperuricemia. AU - Bleyer,Anthony J, AU - Hart,Thomas C, PY - 2006/4/4/pubmed PY - 2006/8/25/medline PY - 2006/4/4/entrez SP - 124 EP - 30 JF - Advances in chronic kidney disease JO - Adv Chronic Kidney Dis VL - 13 IS - 2 N2 - Hyperuricemia and gout are common conditions that have long been known to have a heritable component. Obesity, diabetes, and chronic kidney failure are conditions with multifactorial inheritance that are associated with gout. In addition, social factors such as protein and alcohol intake affect serum uric acid levels. The current review discusses basic uric acid metabolism and the multigenetic inheritance of hyperuricemia. Several monogenic disorders affecting uric acid metabolism are reviewed. The genetics, pathophysiology, diagnosis, and treatment of familial juvenile hyperuricemic nephropathy/medullary cystic kidney disease, autosomal dominant disorders associated with hyperuricemia and progressive kidney failure, are described. SN - 1548-5595 UR - https://www.unboundmedicine.com/medline/citation/16580613/Genetic_factors_associated_with_gout_and_hyperuricemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1548-5595(06)00009-7 DB - PRIME DP - Unbound Medicine ER -