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Augmented cocaine-induced accumbal dopamine efflux, motor activity and place preference in rats fed with a tryptophan-deficient diet.
Neurosci Lett. 2006 Jun 19; 401(1-2):125-9.NL

Abstract

In the present study we demonstrate that consumption of a tryptophan-deficient diet for a period of 14 days decreased the striatal serotonin and 5-hydroxyindolacetic acid tissue content in rats, whereas the level of dopamine remained unchanged. Under this condition of diminished serotonergic tone, a challenge dose of cocaine (10mg/kg, i.p.) significantly increased motor activity and dopamine extracellular content in the nucleus accumbens compared to rats fed with a balanced diet. We moreover found that pretreatment with cocaine (7 and 10mg/kg, i.p.) produced a significant increase in preference for a cocaine-associated environment in the tryptophan-deficient group compared to control rats. Our experiments show that a low tone of serotonergic system, augments the behavioural reinforcing effect of cocaine and that this effect may be due to a increased cocaine-induced accumbal dopamine release. These data indicate that a tryptophan-deficient diet alters the behavioural and neurochemical effect of psychostimulants, such as cocaine, and suggest an important role of serotonin in modulation of these effects.

Authors+Show Affiliations

Department of Applied Sciences for Biosystems, Section of Physiology and Human Nutrition, University of Cagliari, Via Porcell 4, Cagliari 09124, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16581186

Citation

Carta, M, et al. "Augmented Cocaine-induced Accumbal Dopamine Efflux, Motor Activity and Place Preference in Rats Fed With a Tryptophan-deficient Diet." Neuroscience Letters, vol. 401, no. 1-2, 2006, pp. 125-9.
Carta M, Collu M, Fadda F, et al. Augmented cocaine-induced accumbal dopamine efflux, motor activity and place preference in rats fed with a tryptophan-deficient diet. Neurosci Lett. 2006;401(1-2):125-9.
Carta, M., Collu, M., Fadda, F., & Stancampiano, R. (2006). Augmented cocaine-induced accumbal dopamine efflux, motor activity and place preference in rats fed with a tryptophan-deficient diet. Neuroscience Letters, 401(1-2), 125-9.
Carta M, et al. Augmented Cocaine-induced Accumbal Dopamine Efflux, Motor Activity and Place Preference in Rats Fed With a Tryptophan-deficient Diet. Neurosci Lett. 2006 Jun 19;401(1-2):125-9. PubMed PMID: 16581186.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Augmented cocaine-induced accumbal dopamine efflux, motor activity and place preference in rats fed with a tryptophan-deficient diet. AU - Carta,M, AU - Collu,M, AU - Fadda,F, AU - Stancampiano,R, Y1 - 2006/04/03/ PY - 2005/11/23/received PY - 2006/02/24/revised PY - 2006/03/01/accepted PY - 2006/4/4/pubmed PY - 2006/9/29/medline PY - 2006/4/4/entrez SP - 125 EP - 9 JF - Neuroscience letters JO - Neurosci. Lett. VL - 401 IS - 1-2 N2 - In the present study we demonstrate that consumption of a tryptophan-deficient diet for a period of 14 days decreased the striatal serotonin and 5-hydroxyindolacetic acid tissue content in rats, whereas the level of dopamine remained unchanged. Under this condition of diminished serotonergic tone, a challenge dose of cocaine (10mg/kg, i.p.) significantly increased motor activity and dopamine extracellular content in the nucleus accumbens compared to rats fed with a balanced diet. We moreover found that pretreatment with cocaine (7 and 10mg/kg, i.p.) produced a significant increase in preference for a cocaine-associated environment in the tryptophan-deficient group compared to control rats. Our experiments show that a low tone of serotonergic system, augments the behavioural reinforcing effect of cocaine and that this effect may be due to a increased cocaine-induced accumbal dopamine release. These data indicate that a tryptophan-deficient diet alters the behavioural and neurochemical effect of psychostimulants, such as cocaine, and suggest an important role of serotonin in modulation of these effects. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/16581186/Augmented_cocaine_induced_accumbal_dopamine_efflux_motor_activity_and_place_preference_in_rats_fed_with_a_tryptophan_deficient_diet_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(06)00250-3 DB - PRIME DP - Unbound Medicine ER -