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The role of psychosocial factors in peptic ulcer disease: beyond Helicobacter pylori and NSAIDs.
J Psychosom Res 2006; 60(4):407-12JP

Abstract

A variety of organic etiologies are associated with peptic ulcer disease, and the most relevant of these are infection with Helicobacter pylori and use of nonsteroidal anti-inflammatory drugs. Between 5% and 20% of patients with gastric or duodenal ulcer, however, lack an identifiable organic etiology. In these patients particularly and in all ulcer patients in general, psychosocial factors may play a significant role. At present, there is no definitive study proving a causal relationship between psychological stress and the development of ulcer disease. Studies to date suffer from significant methodological limitations and have not effectively addressed the poor correlation between ulcer craters and ulcer symptoms. A conservative application of available data would suggest that psychosocial factors play a significant role in symptom perception and reporting in patients with dyspeptic symptoms and may play a role in ulcer formation.

Authors+Show Affiliations

Division of Gastroenterology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. mpjones@nmh.org

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16581366

Citation

Jones, Michael P.. "The Role of Psychosocial Factors in Peptic Ulcer Disease: Beyond Helicobacter Pylori and NSAIDs." Journal of Psychosomatic Research, vol. 60, no. 4, 2006, pp. 407-12.
Jones MP. The role of psychosocial factors in peptic ulcer disease: beyond Helicobacter pylori and NSAIDs. J Psychosom Res. 2006;60(4):407-12.
Jones, M. P. (2006). The role of psychosocial factors in peptic ulcer disease: beyond Helicobacter pylori and NSAIDs. Journal of Psychosomatic Research, 60(4), pp. 407-12.
Jones MP. The Role of Psychosocial Factors in Peptic Ulcer Disease: Beyond Helicobacter Pylori and NSAIDs. J Psychosom Res. 2006;60(4):407-12. PubMed PMID: 16581366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of psychosocial factors in peptic ulcer disease: beyond Helicobacter pylori and NSAIDs. A1 - Jones,Michael P, PY - 2005/02/10/received PY - 2006/4/4/pubmed PY - 2006/10/6/medline PY - 2006/4/4/entrez SP - 407 EP - 12 JF - Journal of psychosomatic research JO - J Psychosom Res VL - 60 IS - 4 N2 - A variety of organic etiologies are associated with peptic ulcer disease, and the most relevant of these are infection with Helicobacter pylori and use of nonsteroidal anti-inflammatory drugs. Between 5% and 20% of patients with gastric or duodenal ulcer, however, lack an identifiable organic etiology. In these patients particularly and in all ulcer patients in general, psychosocial factors may play a significant role. At present, there is no definitive study proving a causal relationship between psychological stress and the development of ulcer disease. Studies to date suffer from significant methodological limitations and have not effectively addressed the poor correlation between ulcer craters and ulcer symptoms. A conservative application of available data would suggest that psychosocial factors play a significant role in symptom perception and reporting in patients with dyspeptic symptoms and may play a role in ulcer formation. SN - 0022-3999 UR - https://www.unboundmedicine.com/medline/citation/16581366/The_role_of_psychosocial_factors_in_peptic_ulcer_disease:_beyond_Helicobacter_pylori_and_NSAIDs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3999(05)00313-2 DB - PRIME DP - Unbound Medicine ER -