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Six year incidence and progression of diabetic retinopathy: results from the Mauritius diabetes complication study.
Diabetes Res Clin Pract 2006; 73(3):298-303DR

Abstract

AIMS

To determine the incidence, progression and risk factors for diabetic retinopathy in the multiethnic population of Mauritius.

METHOD

A longitudinal, population-based study was conducted in Mauritius, during 1987, 1992 and 1998. Participants identified through the study as having diabetes (both known and newly diagnosed, by self-report and oral glucose tolerance test) and one in four participants with impaired glucose tolerance (IGT) underwent complications screening in 1992 and 1998. Retinal photographs were taken using a TRC-50VT retinal camera in three fields of the right eye (centred on the optic disc; macula (temporal to the optic disc); and nasal to disc). Photographs were graded according to a simplified version of the Wisconsin grading system.

RESULTS

The 6-year incidence of diabetic retinopathy was 23.8% (sight-threatening in 0.4%). Among those with known diabetes mellitus (KDM) and free of retinopathy at baseline the incidence of non-proliferative diabetic retinopathy (NPDR) was 29.2% and proliferative diabetic retinopathy (PDR) was 1.0%. Among those with newly diagnosed diabetes mellitus (NDM) at baseline the incidence of NPDR was 19.1% (no incident cases of PDR were found). Independent risk factors for retinopathy using the baseline population characteristics were duration of diabetes and fasting plasma glucose.

CONCLUSIONS

This is one of the few recent population-based studies of diabetic retinopathy undertaken in a developing nation. The incidence of retinopathy in Mauritius was high among those with NDM at baseline, with one in five developing retinopathy over 6 years. These results support the concept that screening for diabetes is important.

Authors+Show Affiliations

Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia. Robyn.Tapp@med.monash.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16584802

Citation

Tapp, Robyn J., et al. "Six Year Incidence and Progression of Diabetic Retinopathy: Results From the Mauritius Diabetes Complication Study." Diabetes Research and Clinical Practice, vol. 73, no. 3, 2006, pp. 298-303.
Tapp RJ, Zimmet PZ, Harper CA, et al. Six year incidence and progression of diabetic retinopathy: results from the Mauritius diabetes complication study. Diabetes Res Clin Pract. 2006;73(3):298-303.
Tapp, R. J., Zimmet, P. Z., Harper, C. A., McCarty, D. J., Chitson, P., Tonkin, A. M., ... Shaw, J. E. (2006). Six year incidence and progression of diabetic retinopathy: results from the Mauritius diabetes complication study. Diabetes Research and Clinical Practice, 73(3), pp. 298-303.
Tapp RJ, et al. Six Year Incidence and Progression of Diabetic Retinopathy: Results From the Mauritius Diabetes Complication Study. Diabetes Res Clin Pract. 2006;73(3):298-303. PubMed PMID: 16584802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Six year incidence and progression of diabetic retinopathy: results from the Mauritius diabetes complication study. AU - Tapp,Robyn J, AU - Zimmet,Paul Z, AU - Harper,C Alex, AU - McCarty,Daniel J, AU - Chitson,Pierrot, AU - Tonkin,Andrew M, AU - Söderberg,Stefan, AU - Taylor,Hugh R, AU - Alberti,K G M M, AU - Tuomilehto,Jaakko, AU - Shaw,Jonathan E, Y1 - 2006/04/03/ PY - 2005/06/13/received PY - 2005/12/13/revised PY - 2006/02/08/accepted PY - 2006/4/6/pubmed PY - 2007/1/9/medline PY - 2006/4/6/entrez SP - 298 EP - 303 JF - Diabetes research and clinical practice JO - Diabetes Res. Clin. Pract. VL - 73 IS - 3 N2 - AIMS: To determine the incidence, progression and risk factors for diabetic retinopathy in the multiethnic population of Mauritius. METHOD: A longitudinal, population-based study was conducted in Mauritius, during 1987, 1992 and 1998. Participants identified through the study as having diabetes (both known and newly diagnosed, by self-report and oral glucose tolerance test) and one in four participants with impaired glucose tolerance (IGT) underwent complications screening in 1992 and 1998. Retinal photographs were taken using a TRC-50VT retinal camera in three fields of the right eye (centred on the optic disc; macula (temporal to the optic disc); and nasal to disc). Photographs were graded according to a simplified version of the Wisconsin grading system. RESULTS: The 6-year incidence of diabetic retinopathy was 23.8% (sight-threatening in 0.4%). Among those with known diabetes mellitus (KDM) and free of retinopathy at baseline the incidence of non-proliferative diabetic retinopathy (NPDR) was 29.2% and proliferative diabetic retinopathy (PDR) was 1.0%. Among those with newly diagnosed diabetes mellitus (NDM) at baseline the incidence of NPDR was 19.1% (no incident cases of PDR were found). Independent risk factors for retinopathy using the baseline population characteristics were duration of diabetes and fasting plasma glucose. CONCLUSIONS: This is one of the few recent population-based studies of diabetic retinopathy undertaken in a developing nation. The incidence of retinopathy in Mauritius was high among those with NDM at baseline, with one in five developing retinopathy over 6 years. These results support the concept that screening for diabetes is important. SN - 0168-8227 UR - https://www.unboundmedicine.com/medline/citation/16584802/Six_year_incidence_and_progression_of_diabetic_retinopathy:_results_from_the_Mauritius_diabetes_complication_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(06)00061-1 DB - PRIME DP - Unbound Medicine ER -