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Capsaicin-induced vasoconstriction in the mouse knee joint: a study using TRPV1 knockout mice.
Neurosci Lett. 2006 Jun 19; 401(1-2):55-8.NL

Abstract

Capsaicin is the pungent component of chilli peppers that concomitantly activates and desensitizes C-fibre and Adelta sensory nerve fibres. Stimulation causes an acute neurogenic response including vasodilation, plasma extravasation and hypersensitivity. However, in the present study we have shown that capsaicin produces a dose-dependent vasoconstrictor effect in the mouse knee joint via Transient Receptor Potential Vanilloid 1 (TRPV1) receptor activation. A (125)I-albumin accumulation technique showed that the intravascular volume of capsaicin-treated joints in wild type (WT) mice was significantly reduced compared to TRPV1 knockout mice (p<0.01). Similarly, a laser Doppler technique showed significantly reduced blood flow in the capsaicin-treated joints of WT compared to TRPV1 knockout mice (p<0.001). Pretreatment with guanethinidine (50 mg kg(-1), i.p.) had no effect on the vasoconstriction. These data are important considering the involvement of TRPV1 receptors in joint disease. The mechanisms underlying the vasoconstriction therefore require further investigation.

Authors+Show Affiliations

Cardiovascular Division, New Hunt's House, King's College London, Guy's Campus, SE1 1UL, UK. julie.keeble@kcl.ac.ukNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16584841

Citation

Keeble, Julie Elizabeth, and Susan Diana Brain. "Capsaicin-induced Vasoconstriction in the Mouse Knee Joint: a Study Using TRPV1 Knockout Mice." Neuroscience Letters, vol. 401, no. 1-2, 2006, pp. 55-8.
Keeble JE, Brain SD. Capsaicin-induced vasoconstriction in the mouse knee joint: a study using TRPV1 knockout mice. Neurosci Lett. 2006;401(1-2):55-8.
Keeble, J. E., & Brain, S. D. (2006). Capsaicin-induced vasoconstriction in the mouse knee joint: a study using TRPV1 knockout mice. Neuroscience Letters, 401(1-2), 55-8.
Keeble JE, Brain SD. Capsaicin-induced Vasoconstriction in the Mouse Knee Joint: a Study Using TRPV1 Knockout Mice. Neurosci Lett. 2006 Jun 19;401(1-2):55-8. PubMed PMID: 16584841.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Capsaicin-induced vasoconstriction in the mouse knee joint: a study using TRPV1 knockout mice. AU - Keeble,Julie Elizabeth, AU - Brain,Susan Diana, Y1 - 2006/04/03/ PY - 2005/10/13/received PY - 2006/02/07/revised PY - 2006/02/22/accepted PY - 2006/4/6/pubmed PY - 2006/9/29/medline PY - 2006/4/6/entrez SP - 55 EP - 8 JF - Neuroscience letters JO - Neurosci Lett VL - 401 IS - 1-2 N2 - Capsaicin is the pungent component of chilli peppers that concomitantly activates and desensitizes C-fibre and Adelta sensory nerve fibres. Stimulation causes an acute neurogenic response including vasodilation, plasma extravasation and hypersensitivity. However, in the present study we have shown that capsaicin produces a dose-dependent vasoconstrictor effect in the mouse knee joint via Transient Receptor Potential Vanilloid 1 (TRPV1) receptor activation. A (125)I-albumin accumulation technique showed that the intravascular volume of capsaicin-treated joints in wild type (WT) mice was significantly reduced compared to TRPV1 knockout mice (p<0.01). Similarly, a laser Doppler technique showed significantly reduced blood flow in the capsaicin-treated joints of WT compared to TRPV1 knockout mice (p<0.001). Pretreatment with guanethinidine (50 mg kg(-1), i.p.) had no effect on the vasoconstriction. These data are important considering the involvement of TRPV1 receptors in joint disease. The mechanisms underlying the vasoconstriction therefore require further investigation. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/16584841/Capsaicin_induced_vasoconstriction_in_the_mouse_knee_joint:_a_study_using_TRPV1_knockout_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(06)00221-7 DB - PRIME DP - Unbound Medicine ER -