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Pimecrolimus and narrowband UVB as monotherapy or combination therapy in children and adolescents with atopic dermatitis.
Acta Derm Venereol. 2006; 86(1):34-8.AD

Abstract

Topical pimecrolimus and narrowband ultraviolet B (UVB) are both known to be effective in treating atopic dermatitis. We compared the clinical efficacy of monotherapy with either twice daily topical 1% pimecrolimus cream or twice weekly narrowband UVB, and combination therapy in 26 children and adolescents with moderate to severe atopic dermatitis in a half-side manner for 6 weeks. Twenty-four patients completed the study. Monotherapy and combination therapy notably reduced the scores of the Eczema Area and Severity Index (p = 0.002) and the severity of pruritus (p < or = 0.004). There was no significant difference in therapeutic efficacy among the treatment regimens at week 6. In conclusion, because of the lack of short-term additive therapeutic efficacy, concomitant use of pimecrolimus and narrowband UVB is inadvisable in treating moderate to severe atopic dermatitis in children and adolescents.

Authors+Show Affiliations

Department of Dermatology, Veterans General Hospital-Kaohsiung, Kaohsiung, Taiwan. tytzung@isca.vghks.gov.twNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16585987

Citation

Tzung, Tien-Yi, et al. "Pimecrolimus and Narrowband UVB as Monotherapy or Combination Therapy in Children and Adolescents With Atopic Dermatitis." Acta Dermato-venereologica, vol. 86, no. 1, 2006, pp. 34-8.
Tzung TY, Lin CB, Chen YH, et al. Pimecrolimus and narrowband UVB as monotherapy or combination therapy in children and adolescents with atopic dermatitis. Acta Derm Venereol. 2006;86(1):34-8.
Tzung, T. Y., Lin, C. B., Chen, Y. H., & Yang, C. Y. (2006). Pimecrolimus and narrowband UVB as monotherapy or combination therapy in children and adolescents with atopic dermatitis. Acta Dermato-venereologica, 86(1), 34-8.
Tzung TY, et al. Pimecrolimus and Narrowband UVB as Monotherapy or Combination Therapy in Children and Adolescents With Atopic Dermatitis. Acta Derm Venereol. 2006;86(1):34-8. PubMed PMID: 16585987.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pimecrolimus and narrowband UVB as monotherapy or combination therapy in children and adolescents with atopic dermatitis. AU - Tzung,Tien-Yi, AU - Lin,Chyi-Bin, AU - Chen,Ya-Hui, AU - Yang,Chia-Yi, PY - 2006/4/6/pubmed PY - 2006/6/7/medline PY - 2006/4/6/entrez SP - 34 EP - 8 JF - Acta dermato-venereologica JO - Acta Derm. Venereol. VL - 86 IS - 1 N2 - Topical pimecrolimus and narrowband ultraviolet B (UVB) are both known to be effective in treating atopic dermatitis. We compared the clinical efficacy of monotherapy with either twice daily topical 1% pimecrolimus cream or twice weekly narrowband UVB, and combination therapy in 26 children and adolescents with moderate to severe atopic dermatitis in a half-side manner for 6 weeks. Twenty-four patients completed the study. Monotherapy and combination therapy notably reduced the scores of the Eczema Area and Severity Index (p = 0.002) and the severity of pruritus (p < or = 0.004). There was no significant difference in therapeutic efficacy among the treatment regimens at week 6. In conclusion, because of the lack of short-term additive therapeutic efficacy, concomitant use of pimecrolimus and narrowband UVB is inadvisable in treating moderate to severe atopic dermatitis in children and adolescents. SN - 0001-5555 UR - https://www.unboundmedicine.com/medline/citation/16585987/Pimecrolimus_and_narrowband_UVB_as_monotherapy_or_combination_therapy_in_children_and_adolescents_with_atopic_dermatitis_ L2 - https://www.medicaljournals.se/acta/content/abstract/10.1080/00015550510044163 DB - PRIME DP - Unbound Medicine ER -