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Leukotrienes C4, D4, and E4 enhance histamine responsiveness in asthmatic airways.
Am Rev Respir Dis. 1991 Nov; 144(5):1053-7.AR

Abstract

The effects of prior inhalation of each of the sulfidopeptide leukotrienes (LT), LTC4, LTD4, and LTE4 on airway responsiveness to histamine have been compared in seven asthmatic and six normal subjects. Each subject underwent histamine inhalation challenge at 1, 4, and 7 h after inhalation of phosphate-buffered saline and bronchoconstricting doses of LTC4, LTD4, LTE4, and methacholine, which produced a greater than 30% fall in specific airway conductance. In asthmatic subjects, prior inhalation of LTC4, LTD4, and LTE4 enhanced airway responsiveness to histamine when compared with saline inhalation, on average by a maximum of 3.9-, 2.8-, and 3.1-fold, respectively, at 4 h after inhalation. Methacholine inhalation did not significantly after histamine responsiveness throughout the time course studied. In normal subjects, inhalation of LTC4, LTD4, LTE4, and methacholine did not change airway responsiveness to histamine. Thus, LTC4 and LTD4 were similar to LTE4 in their capacity to enhance airway responsiveness to histamine in asthmatic subjects, and, in common with LTE4, they failed to elicit a change in airway responsiveness to histamine in normal subjects.

Authors+Show Affiliations

Department of Allergy and Allied Respiratory Disorders, U.M.D.S., Guy's Hospital, London, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1659268

Citation

O'Hickey, S P., et al. "Leukotrienes C4, D4, and E4 Enhance Histamine Responsiveness in Asthmatic Airways." The American Review of Respiratory Disease, vol. 144, no. 5, 1991, pp. 1053-7.
O'Hickey SP, Hawksworth RJ, Fong CY, et al. Leukotrienes C4, D4, and E4 enhance histamine responsiveness in asthmatic airways. Am Rev Respir Dis. 1991;144(5):1053-7.
O'Hickey, S. P., Hawksworth, R. J., Fong, C. Y., Arm, J. P., Spur, B. W., & Lee, T. H. (1991). Leukotrienes C4, D4, and E4 enhance histamine responsiveness in asthmatic airways. The American Review of Respiratory Disease, 144(5), 1053-7.
O'Hickey SP, et al. Leukotrienes C4, D4, and E4 Enhance Histamine Responsiveness in Asthmatic Airways. Am Rev Respir Dis. 1991;144(5):1053-7. PubMed PMID: 1659268.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leukotrienes C4, D4, and E4 enhance histamine responsiveness in asthmatic airways. AU - O'Hickey,S P, AU - Hawksworth,R J, AU - Fong,C Y, AU - Arm,J P, AU - Spur,B W, AU - Lee,T H, PY - 1991/11/1/pubmed PY - 1991/11/1/medline PY - 1991/11/1/entrez SP - 1053 EP - 7 JF - The American review of respiratory disease JO - Am Rev Respir Dis VL - 144 IS - 5 N2 - The effects of prior inhalation of each of the sulfidopeptide leukotrienes (LT), LTC4, LTD4, and LTE4 on airway responsiveness to histamine have been compared in seven asthmatic and six normal subjects. Each subject underwent histamine inhalation challenge at 1, 4, and 7 h after inhalation of phosphate-buffered saline and bronchoconstricting doses of LTC4, LTD4, LTE4, and methacholine, which produced a greater than 30% fall in specific airway conductance. In asthmatic subjects, prior inhalation of LTC4, LTD4, and LTE4 enhanced airway responsiveness to histamine when compared with saline inhalation, on average by a maximum of 3.9-, 2.8-, and 3.1-fold, respectively, at 4 h after inhalation. Methacholine inhalation did not significantly after histamine responsiveness throughout the time course studied. In normal subjects, inhalation of LTC4, LTD4, LTE4, and methacholine did not change airway responsiveness to histamine. Thus, LTC4 and LTD4 were similar to LTE4 in their capacity to enhance airway responsiveness to histamine in asthmatic subjects, and, in common with LTE4, they failed to elicit a change in airway responsiveness to histamine in normal subjects. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/1659268/Leukotrienes_C4_D4_and_E4_enhance_histamine_responsiveness_in_asthmatic_airways_ L2 - https://www.atsjournals.org/doi/10.1164/ajrccm/144.5.1053?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -