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Cardiac troponins as indicators of acute myocardial damage in dogs.
J Vet Intern Med. 2006 Mar-Apr; 20(2):277-83.JV

Abstract

Cardiac troponin I (cTnI) and T (cTnT) have a high sequence homology across phyla and are sensitive and specific markers of myocardial damage. The purpose of this study was to evaluate the Cardiac Reader, a human point-of-care system for the determination of cTnT and myoglobin, and the Abbott Axsym System for the determination of cTnI and creatine kinase isoenzyme MB (CK-MB) in healthy dogs and in dogs at risk for acute myocardial damage because of gastric dilatation-volvulus (GDV) and blunt chest trauma (BCT). In healthy dogs (n = 56), cTnI was below detection limits (<0.1 microg/L) in 35 of 56 dogs (reference range 0-0.7 microg/L), and cTnT was not measurable (<0.05 ng/mL) in all but 1 dog. At presentation, cTnI, CK-MB, myoglobin, and lactic acid were all significantly higher in dogs with GDV (n = 28) and BCT (n = 8) than in control dogs (P < .001), but cTnT was significantly higher only in dogs with BCT (P = .033). Increased cTnI or cTnT values were found in 26 of 28 (highest values 1.1-369 microg/L) and 16 of 28 dogs (0.1-1.7 ng/mL) with GDV, and in 6 of 8 (2.3-82.4 microg/L) and 3 of 8 dogs (0.1-0.29 ng/mL) with BCT, respectively. In dogs suffering from GDV, cTnI and cTnT increased further within the first 48 hours (P < .001). Increased cardiac troponins suggestive of myocardial damage occurred in 93% of dogs with GDV and 75% with BCT. cTnI appeared more sensitive, but cTnT may be a negative prognostic indicator in GDV. Both systems tested seemed applicable for the measurement of canine cardiac troponins, with the Cardiac Reader particularly suitable for use in emergency settings.

Authors+Show Affiliations

Burgener IA
Department of Clinical Veterinary Medicine, Division of Small Animal Internal Medicine, Vetsuisse Faculty of the University of Bern, Switzerland. iwan.burgener@kkh.unibe.ch
Kovacevic A
No affiliation info available
Mauldin GN
No affiliation info available
Lombard CW
No affiliation info available

MeSH

AnimalsBiomarkersDog DiseasesDogsFemaleGastric DilatationHeart DiseasesMaleMyoglobinPoint-of-Care SystemsReagent Kits, DiagnosticRisk FactorsStomach VolvulusTroponin CTroponin IWounds, Nonpenetrating

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16594583

Citation

Burgener, Iwan A., et al. "Cardiac Troponins as Indicators of Acute Myocardial Damage in Dogs." Journal of Veterinary Internal Medicine, vol. 20, no. 2, 2006, pp. 277-83.
Burgener IA, Kovacevic A, Mauldin GN, et al. Cardiac troponins as indicators of acute myocardial damage in dogs. J Vet Intern Med. 2006;20(2):277-83.
Burgener, I. A., Kovacevic, A., Mauldin, G. N., & Lombard, C. W. (2006). Cardiac troponins as indicators of acute myocardial damage in dogs. Journal of Veterinary Internal Medicine, 20(2), 277-83.
Burgener IA, et al. Cardiac Troponins as Indicators of Acute Myocardial Damage in Dogs. J Vet Intern Med. 2006 Mar-Apr;20(2):277-83. PubMed PMID: 16594583.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiac troponins as indicators of acute myocardial damage in dogs. AU - Burgener,Iwan A, AU - Kovacevic,Alan, AU - Mauldin,G Neal, AU - Lombard,Christophe W, PY - 2006/4/6/pubmed PY - 2006/5/19/medline PY - 2006/4/6/entrez SP - 277 EP - 83 JF - Journal of veterinary internal medicine JO - J Vet Intern Med VL - 20 IS - 2 N2 - Cardiac troponin I (cTnI) and T (cTnT) have a high sequence homology across phyla and are sensitive and specific markers of myocardial damage. The purpose of this study was to evaluate the Cardiac Reader, a human point-of-care system for the determination of cTnT and myoglobin, and the Abbott Axsym System for the determination of cTnI and creatine kinase isoenzyme MB (CK-MB) in healthy dogs and in dogs at risk for acute myocardial damage because of gastric dilatation-volvulus (GDV) and blunt chest trauma (BCT). In healthy dogs (n = 56), cTnI was below detection limits (<0.1 microg/L) in 35 of 56 dogs (reference range 0-0.7 microg/L), and cTnT was not measurable (<0.05 ng/mL) in all but 1 dog. At presentation, cTnI, CK-MB, myoglobin, and lactic acid were all significantly higher in dogs with GDV (n = 28) and BCT (n = 8) than in control dogs (P < .001), but cTnT was significantly higher only in dogs with BCT (P = .033). Increased cTnI or cTnT values were found in 26 of 28 (highest values 1.1-369 microg/L) and 16 of 28 dogs (0.1-1.7 ng/mL) with GDV, and in 6 of 8 (2.3-82.4 microg/L) and 3 of 8 dogs (0.1-0.29 ng/mL) with BCT, respectively. In dogs suffering from GDV, cTnI and cTnT increased further within the first 48 hours (P < .001). Increased cardiac troponins suggestive of myocardial damage occurred in 93% of dogs with GDV and 75% with BCT. cTnI appeared more sensitive, but cTnT may be a negative prognostic indicator in GDV. Both systems tested seemed applicable for the measurement of canine cardiac troponins, with the Cardiac Reader particularly suitable for use in emergency settings. SN - 0891-6640 UR - https://www.unboundmedicine.com/medline/citation/16594583/Cardiac_troponins_as_indicators_of_acute_myocardial_damage_in_dogs_ DB - PRIME DP - Unbound Medicine ER -