Tags

Type your tag names separated by a space and hit enter

RETRACTED ARTICLE

Immunological factors and their role in the genesis and development of endometriosis.

Abstract

The article presents an overview of immunological factors and their role in the genesis and development of endometriosis, with emphasis on inflammatory cytokines and growth and adhesion factors. Although retrograde menstruation is a common phenomenon among women of reproductive age, not all women with retrograde menstruation suffer the disease. Development of endometriosis seems to be a complex process, facilitated by several factors, including quantity and quality of endometrial cells in peritoneal fluid (PF), increased inflammatory activity in PF, increased endometrial-peritoneal adhesion and angiogenesis, reduced immune surveillance and clearance of endometrial cells, and increased production of autoantibodies against endometrial cells. Potential biomarkers like cytokines and autoantibodies, upregulated during development of endometriosis, seem useful in the development of a non-surgical diagnostic tool. In this review work, the immune role in endometriosis is examined through the role of immunological factors in the genesis and development of the disease. Furthermore, it could be concluded that, although endometriosis can be treated using hormonal suppression, there is a need today for non-hormonal drugs, probably to modulate immune function, in order to confront the disease and alleviate pain or infertility without inhibition of ovulation.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Third Department of Obstetrics and Gynecology, University of Athens Medical School, Attikon Hospital, Athens, Greece. harrysiri@hotmail.com

    , , ,

    Source

    MeSH

    Ascitic Fluid
    Autoantibodies
    Cytokines
    Endometriosis
    Female
    Growth Substances
    Humans
    Interleukins
    Leptin
    Macrophages
    Matrix Metalloproteinases
    Reactive Oxygen Species
    Tumor Necrosis Factors

    Pub Type(s)

    Journal Article
    Retracted Publication
    Review

    Language

    eng

    PubMed ID

    16594919

    Citation

    Siristatidis, Charalambos, et al. "Immunological Factors and Their Role in the Genesis and Development of Endometriosis." The Journal of Obstetrics and Gynaecology Research, vol. 32, no. 2, 2006, pp. 162-70.
    Siristatidis C, Nissotakis C, Chrelias C, et al. Immunological factors and their role in the genesis and development of endometriosis. J Obstet Gynaecol Res. 2006;32(2):162-70.
    Siristatidis, C., Nissotakis, C., Chrelias, C., Iacovidou, H., & Salamalekis, E. (2006). Immunological factors and their role in the genesis and development of endometriosis. The Journal of Obstetrics and Gynaecology Research, 32(2), pp. 162-70.
    Siristatidis C, et al. Immunological Factors and Their Role in the Genesis and Development of Endometriosis. J Obstet Gynaecol Res. 2006;32(2):162-70. PubMed PMID: 16594919.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Immunological factors and their role in the genesis and development of endometriosis. AU - Siristatidis,Charalambos, AU - Nissotakis,Christos, AU - Chrelias,Charalambos, AU - Iacovidou,Helen, AU - Salamalekis,Emmanuel, PY - 2006/4/6/pubmed PY - 2006/8/25/medline PY - 2006/4/6/entrez SP - 162 EP - 70 JF - The journal of obstetrics and gynaecology research JO - J. Obstet. Gynaecol. Res. VL - 32 IS - 2 N2 - The article presents an overview of immunological factors and their role in the genesis and development of endometriosis, with emphasis on inflammatory cytokines and growth and adhesion factors. Although retrograde menstruation is a common phenomenon among women of reproductive age, not all women with retrograde menstruation suffer the disease. Development of endometriosis seems to be a complex process, facilitated by several factors, including quantity and quality of endometrial cells in peritoneal fluid (PF), increased inflammatory activity in PF, increased endometrial-peritoneal adhesion and angiogenesis, reduced immune surveillance and clearance of endometrial cells, and increased production of autoantibodies against endometrial cells. Potential biomarkers like cytokines and autoantibodies, upregulated during development of endometriosis, seem useful in the development of a non-surgical diagnostic tool. In this review work, the immune role in endometriosis is examined through the role of immunological factors in the genesis and development of the disease. Furthermore, it could be concluded that, although endometriosis can be treated using hormonal suppression, there is a need today for non-hormonal drugs, probably to modulate immune function, in order to confront the disease and alleviate pain or infertility without inhibition of ovulation. SN - 1341-8076 UR - https://www.unboundmedicine.com/medline/citation/16594919/Immunological_factors_and_their_role_in_the_genesis_and_development_of_endometriosis_ L2 - https://doi.org/10.1111/j.1447-0756.2006.00373.x DB - PRIME DP - Unbound Medicine ER -