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RETRACTED ARTICLE

Immunological factors and their role in the genesis and development of endometriosis.
J Obstet Gynaecol Res 2006; 32(2):162-70JO

Abstract

The article presents an overview of immunological factors and their role in the genesis and development of endometriosis, with emphasis on inflammatory cytokines and growth and adhesion factors. Although retrograde menstruation is a common phenomenon among women of reproductive age, not all women with retrograde menstruation suffer the disease. Development of endometriosis seems to be a complex process, facilitated by several factors, including quantity and quality of endometrial cells in peritoneal fluid (PF), increased inflammatory activity in PF, increased endometrial-peritoneal adhesion and angiogenesis, reduced immune surveillance and clearance of endometrial cells, and increased production of autoantibodies against endometrial cells. Potential biomarkers like cytokines and autoantibodies, upregulated during development of endometriosis, seem useful in the development of a non-surgical diagnostic tool. In this review work, the immune role in endometriosis is examined through the role of immunological factors in the genesis and development of the disease. Furthermore, it could be concluded that, although endometriosis can be treated using hormonal suppression, there is a need today for non-hormonal drugs, probably to modulate immune function, in order to confront the disease and alleviate pain or infertility without inhibition of ovulation.

Authors+Show Affiliations

Third Department of Obstetrics and Gynecology, University of Athens Medical School, Attikon Hospital, Athens, Greece. harrysiri@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Retracted Publication
Review

Language

eng

PubMed ID

16594919

Citation

Siristatidis, Charalambos, et al. "Immunological Factors and Their Role in the Genesis and Development of Endometriosis." The Journal of Obstetrics and Gynaecology Research, vol. 32, no. 2, 2006, pp. 162-70.
Siristatidis C, Nissotakis C, Chrelias C, et al. Immunological factors and their role in the genesis and development of endometriosis. J Obstet Gynaecol Res. 2006;32(2):162-70.
Siristatidis, C., Nissotakis, C., Chrelias, C., Iacovidou, H., & Salamalekis, E. (2006). Immunological factors and their role in the genesis and development of endometriosis. The Journal of Obstetrics and Gynaecology Research, 32(2), pp. 162-70.
Siristatidis C, et al. Immunological Factors and Their Role in the Genesis and Development of Endometriosis. J Obstet Gynaecol Res. 2006;32(2):162-70. PubMed PMID: 16594919.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunological factors and their role in the genesis and development of endometriosis. AU - Siristatidis,Charalambos, AU - Nissotakis,Christos, AU - Chrelias,Charalambos, AU - Iacovidou,Helen, AU - Salamalekis,Emmanuel, PY - 2006/4/6/pubmed PY - 2006/8/25/medline PY - 2006/4/6/entrez SP - 162 EP - 70 JF - The journal of obstetrics and gynaecology research JO - J. Obstet. Gynaecol. Res. VL - 32 IS - 2 N2 - The article presents an overview of immunological factors and their role in the genesis and development of endometriosis, with emphasis on inflammatory cytokines and growth and adhesion factors. Although retrograde menstruation is a common phenomenon among women of reproductive age, not all women with retrograde menstruation suffer the disease. Development of endometriosis seems to be a complex process, facilitated by several factors, including quantity and quality of endometrial cells in peritoneal fluid (PF), increased inflammatory activity in PF, increased endometrial-peritoneal adhesion and angiogenesis, reduced immune surveillance and clearance of endometrial cells, and increased production of autoantibodies against endometrial cells. Potential biomarkers like cytokines and autoantibodies, upregulated during development of endometriosis, seem useful in the development of a non-surgical diagnostic tool. In this review work, the immune role in endometriosis is examined through the role of immunological factors in the genesis and development of the disease. Furthermore, it could be concluded that, although endometriosis can be treated using hormonal suppression, there is a need today for non-hormonal drugs, probably to modulate immune function, in order to confront the disease and alleviate pain or infertility without inhibition of ovulation. SN - 1341-8076 UR - https://www.unboundmedicine.com/medline/citation/16594919/Immunological_factors_and_their_role_in_the_genesis_and_development_of_endometriosis_ L2 - https://doi.org/10.1111/j.1447-0756.2006.00373.x DB - PRIME DP - Unbound Medicine ER -