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Clozapine in schizophrenia patients with recurrent catatonia: report of two cases.
Psychiatry Clin Neurosci. 2006 Apr; 60(2):256-8.PC

Abstract

Prolonged catatonia can be a source of extremely serious morbidity and mortality. Lorazepam is effective in rapidly relieving most cases of catatonia. Reports have also shown that second-generation antipsychotic drugs are also efficacious in relieving catatonia. This report describes two schizophrenia patients who demonstrated recurrent catatonic features mutism and stupor. Both patients were treated with lorazepam, diazepam or electroconvulsive therapy (ECT). Patient 1 responded well and rapidly to lorazepam each time catatonia happened; but catatonia recurred once a year under treatment with many antipsychotic drugs. Patient 2 had catatonia features associated with discontinuing or decreasing clozapine. With each recurrent episode, the duration of catatonia increased, requiring an increased dosage of benzodiazepine. The patient's response to lorazepam and ECT gradually decreased, until the patient had almost no response to lorazepam, diazepam or ECT. Both patients had no recurrence during a period of 2-year follow up with continuous clozapine therapy.

Authors+Show Affiliations

Department of psychiatry, Chang Gung Memorial Hospital, Kaohsiung, Taiwan.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16594953

Citation

Hung, Yi-Yung, et al. "Clozapine in Schizophrenia Patients With Recurrent Catatonia: Report of Two Cases." Psychiatry and Clinical Neurosciences, vol. 60, no. 2, 2006, pp. 256-8.
Hung YY, Yang PS, Huang TL. Clozapine in schizophrenia patients with recurrent catatonia: report of two cases. Psychiatry Clin Neurosci. 2006;60(2):256-8.
Hung, Y. Y., Yang, P. S., & Huang, T. L. (2006). Clozapine in schizophrenia patients with recurrent catatonia: report of two cases. Psychiatry and Clinical Neurosciences, 60(2), 256-8.
Hung YY, Yang PS, Huang TL. Clozapine in Schizophrenia Patients With Recurrent Catatonia: Report of Two Cases. Psychiatry Clin Neurosci. 2006;60(2):256-8. PubMed PMID: 16594953.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clozapine in schizophrenia patients with recurrent catatonia: report of two cases. AU - Hung,Yi-Yung, AU - Yang,Ping-Suen, AU - Huang,Tiao-Lai, PY - 2006/4/6/pubmed PY - 2006/6/7/medline PY - 2006/4/6/entrez SP - 256 EP - 8 JF - Psychiatry and clinical neurosciences JO - Psychiatry Clin. Neurosci. VL - 60 IS - 2 N2 - Prolonged catatonia can be a source of extremely serious morbidity and mortality. Lorazepam is effective in rapidly relieving most cases of catatonia. Reports have also shown that second-generation antipsychotic drugs are also efficacious in relieving catatonia. This report describes two schizophrenia patients who demonstrated recurrent catatonic features mutism and stupor. Both patients were treated with lorazepam, diazepam or electroconvulsive therapy (ECT). Patient 1 responded well and rapidly to lorazepam each time catatonia happened; but catatonia recurred once a year under treatment with many antipsychotic drugs. Patient 2 had catatonia features associated with discontinuing or decreasing clozapine. With each recurrent episode, the duration of catatonia increased, requiring an increased dosage of benzodiazepine. The patient's response to lorazepam and ECT gradually decreased, until the patient had almost no response to lorazepam, diazepam or ECT. Both patients had no recurrence during a period of 2-year follow up with continuous clozapine therapy. SN - 1323-1316 UR - https://www.unboundmedicine.com/medline/citation/16594953/Clozapine_in_schizophrenia_patients_with_recurrent_catatonia:_report_of_two_cases_ L2 - https://doi.org/10.1111/j.1440-1819.2006.01495.x DB - PRIME DP - Unbound Medicine ER -