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Prediagnostic level of serum retinol in relation to reduced risk of hepatocellular carcinoma.

Abstract

BACKGROUND

Retinol and its derivatives (retinoids), which have antioxidant activity and promote cell differentiation, may protect against the development of hepatocellular carcinoma (HCC) by controlling hepatocellular differentiation and reducing inflammatory responses.

METHODS

We examined prospectively the relationship between prediagnostic serum concentrations of retinol, alpha-carotene; beta-carotene; beta-cryptoxanthin; lutein; lycopene; zeaxanthin; alpha-, gamma-, and delta-tocopherols; and selenium and the risk of developing HCC among 213 patients with HCC and 1087 matched control subjects from a cohort of 18,244 men in Shanghai, China, who were monitored from 1986 through 2001. Odds ratios (ORs) and 95% confidence intervals (CIs) for men by quartile of serum concentrations of micronutrients were estimated by using logistic regression with adjustment for cigarette smoking status, alcohol intake, self-reported history of physician-diagnosed hepatitis or liver cirrhosis at recruitment, and seropositivity for hepatitis B surface antigen (HBsAg). All statistical tests were two-sided.

RESULTS

Men with high prediagnostic serum retinol levels had a lower risk of HCC than men in the lowest quartile (Q2 versus Q1, OR = 0.37, 95% CI = 0.22 to 0.61; Q3 versus Q1, OR = 0.30, 95% CI = 0.17 to 0.50; and Q4 versus Q1, OR = 0.13, 95% CI = 0.06 to 0.26; Ptrend < .001). A statistically significant interaction was observed between retinol and HBsAg seropositivity on HCC risk; HBsAg-positive men in the lowest tertile of retinol had a greater than 70-fold higher risk (OR = 72.7, 95% CI = 31.6 to 167.4) of HCC than HBsAg-negative men in the highest tertile of retinol (Pinteraction = .018). No independent effect of serum levels of alpha-carotene; beta-carotene; beta-cryptoxanthin; lutein; lycopene; zeaxanthin; alpha-, gamma-, and delta-tocopherols; or selenium on HCC risk were observed.

CONCLUSION

High prediagnostic serum level of retinol is associated with a decreased risk of HCC in this population.

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  • Authors+Show Affiliations

    ,

    The Cancer Center, University of Minnesota, Minneapolis, MN, USA. jyuan@umn.edu

    , , ,

    Source

    Journal of the National Cancer Institute 98:7 2006 Apr 05 pg 482-90

    MeSH

    Carcinoma, Hepatocellular
    Carotenoids
    Case-Control Studies
    China
    Cryptoxanthins
    Humans
    Incidence
    Liver Neoplasms
    Logistic Models
    Lutein
    Lycopene
    Male
    Micronutrients
    Middle Aged
    Odds Ratio
    Prospective Studies
    Risk Assessment
    Risk Factors
    Selenium
    Tocopherols
    Vitamin A
    Xanthophylls
    Zeaxanthins
    beta Carotene

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    16595784

    Citation

    Yuan, Jian-Min, et al. "Prediagnostic Level of Serum Retinol in Relation to Reduced Risk of Hepatocellular Carcinoma." Journal of the National Cancer Institute, vol. 98, no. 7, 2006, pp. 482-90.
    Yuan JM, Gao YT, Ong CN, et al. Prediagnostic level of serum retinol in relation to reduced risk of hepatocellular carcinoma. J Natl Cancer Inst. 2006;98(7):482-90.
    Yuan, J. M., Gao, Y. T., Ong, C. N., Ross, R. K., & Yu, M. C. (2006). Prediagnostic level of serum retinol in relation to reduced risk of hepatocellular carcinoma. Journal of the National Cancer Institute, 98(7), pp. 482-90.
    Yuan JM, et al. Prediagnostic Level of Serum Retinol in Relation to Reduced Risk of Hepatocellular Carcinoma. J Natl Cancer Inst. 2006 Apr 5;98(7):482-90. PubMed PMID: 16595784.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prediagnostic level of serum retinol in relation to reduced risk of hepatocellular carcinoma. AU - Yuan,Jian-Min, AU - Gao,Yu-Tang, AU - Ong,Choon-Nam, AU - Ross,Ronald K, AU - Yu,Mimi C, PY - 2006/4/6/pubmed PY - 2006/4/13/medline PY - 2006/4/6/entrez SP - 482 EP - 90 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 98 IS - 7 N2 - BACKGROUND: Retinol and its derivatives (retinoids), which have antioxidant activity and promote cell differentiation, may protect against the development of hepatocellular carcinoma (HCC) by controlling hepatocellular differentiation and reducing inflammatory responses. METHODS: We examined prospectively the relationship between prediagnostic serum concentrations of retinol, alpha-carotene; beta-carotene; beta-cryptoxanthin; lutein; lycopene; zeaxanthin; alpha-, gamma-, and delta-tocopherols; and selenium and the risk of developing HCC among 213 patients with HCC and 1087 matched control subjects from a cohort of 18,244 men in Shanghai, China, who were monitored from 1986 through 2001. Odds ratios (ORs) and 95% confidence intervals (CIs) for men by quartile of serum concentrations of micronutrients were estimated by using logistic regression with adjustment for cigarette smoking status, alcohol intake, self-reported history of physician-diagnosed hepatitis or liver cirrhosis at recruitment, and seropositivity for hepatitis B surface antigen (HBsAg). All statistical tests were two-sided. RESULTS: Men with high prediagnostic serum retinol levels had a lower risk of HCC than men in the lowest quartile (Q2 versus Q1, OR = 0.37, 95% CI = 0.22 to 0.61; Q3 versus Q1, OR = 0.30, 95% CI = 0.17 to 0.50; and Q4 versus Q1, OR = 0.13, 95% CI = 0.06 to 0.26; Ptrend < .001). A statistically significant interaction was observed between retinol and HBsAg seropositivity on HCC risk; HBsAg-positive men in the lowest tertile of retinol had a greater than 70-fold higher risk (OR = 72.7, 95% CI = 31.6 to 167.4) of HCC than HBsAg-negative men in the highest tertile of retinol (Pinteraction = .018). No independent effect of serum levels of alpha-carotene; beta-carotene; beta-cryptoxanthin; lutein; lycopene; zeaxanthin; alpha-, gamma-, and delta-tocopherols; or selenium on HCC risk were observed. CONCLUSION: High prediagnostic serum level of retinol is associated with a decreased risk of HCC in this population. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/16595784/Prediagnostic_level_of_serum_retinol_in_relation_to_reduced_risk_of_hepatocellular_carcinoma_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djj104 DB - PRIME DP - Unbound Medicine ER -