Tags

Type your tag names separated by a space and hit enter

The effects of histaminergic agents in the ventral hippocampus of rats in the plus-maze test of anxiety-like behaviours.
Physiol Behav. 2006 May 30; 87(5):891-6.PB

Abstract

It has been suggested that histamine have modulatory influence on anxiety-related behaviours both in animals and humans. Ventral hippocampus (VHC) may also be an important brain site in the modulation of fear or anxiety. In the present study, the effects of histaminergic agents on anxiety-related behaviours in the rats, using plus-maze test has been investigated. Intra-VHC administration of histamine (2.5, 5 and 7.5 microg/rat) decreased %OAT and %OAE but not locomotor activity, showing an anxiogenic response. Pretreatment of animals with either pyrilamine, a H1 receptor antagonist (10 microg/rat), or ranitidine, a H2 receptor antagonist (10 microg/rat) reverse anxiogenic response of histamine (2.5, 5 and 7.5 microg/rat). However, intra-VHC microinjection of higher doses of pyrilamine (40 microg/rat) or ranitidine (20 and 40 microg/rat) alone increased anxiety-like behaviours in rats. Our results showed that histamine may modulate anxiety-like behaviours via H1 and H2 receptors in the ventral hippocampus of the rats.

Authors+Show Affiliations

Department of Physiology, Tarbiat Moallem University, Tehran, Iran.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16600315

Citation

Rostami, Parvin, et al. "The Effects of Histaminergic Agents in the Ventral Hippocampus of Rats in the Plus-maze Test of Anxiety-like Behaviours." Physiology & Behavior, vol. 87, no. 5, 2006, pp. 891-6.
Rostami P, Hajizadeh-Moghaddam A, Zarrindast MR. The effects of histaminergic agents in the ventral hippocampus of rats in the plus-maze test of anxiety-like behaviours. Physiol Behav. 2006;87(5):891-6.
Rostami, P., Hajizadeh-Moghaddam, A., & Zarrindast, M. R. (2006). The effects of histaminergic agents in the ventral hippocampus of rats in the plus-maze test of anxiety-like behaviours. Physiology & Behavior, 87(5), 891-6.
Rostami P, Hajizadeh-Moghaddam A, Zarrindast MR. The Effects of Histaminergic Agents in the Ventral Hippocampus of Rats in the Plus-maze Test of Anxiety-like Behaviours. Physiol Behav. 2006 May 30;87(5):891-6. PubMed PMID: 16600315.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of histaminergic agents in the ventral hippocampus of rats in the plus-maze test of anxiety-like behaviours. AU - Rostami,Parvin, AU - Hajizadeh-Moghaddam,Akbar, AU - Zarrindast,Mohammad-Reza, Y1 - 2006/03/06/ PY - 2006/01/15/received PY - 2006/02/01/accepted PY - 2006/4/8/pubmed PY - 2006/7/27/medline PY - 2006/4/8/entrez SP - 891 EP - 6 JF - Physiology & behavior JO - Physiol Behav VL - 87 IS - 5 N2 - It has been suggested that histamine have modulatory influence on anxiety-related behaviours both in animals and humans. Ventral hippocampus (VHC) may also be an important brain site in the modulation of fear or anxiety. In the present study, the effects of histaminergic agents on anxiety-related behaviours in the rats, using plus-maze test has been investigated. Intra-VHC administration of histamine (2.5, 5 and 7.5 microg/rat) decreased %OAT and %OAE but not locomotor activity, showing an anxiogenic response. Pretreatment of animals with either pyrilamine, a H1 receptor antagonist (10 microg/rat), or ranitidine, a H2 receptor antagonist (10 microg/rat) reverse anxiogenic response of histamine (2.5, 5 and 7.5 microg/rat). However, intra-VHC microinjection of higher doses of pyrilamine (40 microg/rat) or ranitidine (20 and 40 microg/rat) alone increased anxiety-like behaviours in rats. Our results showed that histamine may modulate anxiety-like behaviours via H1 and H2 receptors in the ventral hippocampus of the rats. SN - 0031-9384 UR - https://www.unboundmedicine.com/medline/citation/16600315/The_effects_of_histaminergic_agents_in_the_ventral_hippocampus_of_rats_in_the_plus_maze_test_of_anxiety_like_behaviours_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9384(06)00058-8 DB - PRIME DP - Unbound Medicine ER -