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The sequential changes in the fasting plasma glucose levels within normoglycemic range predict type 2 diabetes in healthy, young men.
Diabetes Res Clin Pract. 2006 Sep; 73(3):329-35.DR

Abstract

AIMS

We assessed whether the increased sequential changes in the fasting plasma glucose level (FPG) that is still within the normoglycemic range could be a predictor for future diabetes.

METHODS

A prospective cohort study was conducted with 5296 male employees, aged 31-44 years. A sequential change in the FPG level was defined as the first follow-up FPG level minus the baseline FPG level. The incident diabetes was assessed at annual examinations during the next 4.1 years. Cox proportional hazard analyses were performed.

RESULTS

During the 21,575.5 person-years follow-up among the 5,296 subjects, a total of 156 incident cases of type 2 diabetes occurred (116 cases among the 4,975 normoglycemic subjects and 40 cases among the 321 subjects with impaired fasting glucose). An increase in the FPG level from the baseline to the first follow-up, although still within the normoglycemic range (FPG<100 mg/dl), significantly predicted future diabetes: the multivariate hazard ratios associated with the sequential changes in the FPG of <-3, -3 to 3, 4-6, 7-9, and >9 mg/dl were 0.75, 1.00 (reference), 2.28, 3.28, and 6.10, respectively (p for trend <0.001).

CONCLUSIONS

The increase of the sequential changes in the FPG level that were within the normal glucose range was associated with a higher risk for developing diabetes. Thus, conducting assessment for the serial changes in the FPG level may help to identify the young, healthy, normoglycemic individuals at risk for type 2 diabetes.

Authors+Show Affiliations

Department of Family Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Jongno-Gu, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16600415

Citation

Park, Yong-Woo, et al. "The Sequential Changes in the Fasting Plasma Glucose Levels Within Normoglycemic Range Predict Type 2 Diabetes in Healthy, Young Men." Diabetes Research and Clinical Practice, vol. 73, no. 3, 2006, pp. 329-35.
Park YW, Chang Y, Sung KC, et al. The sequential changes in the fasting plasma glucose levels within normoglycemic range predict type 2 diabetes in healthy, young men. Diabetes Res Clin Pract. 2006;73(3):329-35.
Park, Y. W., Chang, Y., Sung, K. C., Ryu, S., Sung, E., & Kim, W. S. (2006). The sequential changes in the fasting plasma glucose levels within normoglycemic range predict type 2 diabetes in healthy, young men. Diabetes Research and Clinical Practice, 73(3), 329-35.
Park YW, et al. The Sequential Changes in the Fasting Plasma Glucose Levels Within Normoglycemic Range Predict Type 2 Diabetes in Healthy, Young Men. Diabetes Res Clin Pract. 2006;73(3):329-35. PubMed PMID: 16600415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The sequential changes in the fasting plasma glucose levels within normoglycemic range predict type 2 diabetes in healthy, young men. AU - Park,Yong-Woo, AU - Chang,Yoosoo, AU - Sung,Ki Chul, AU - Ryu,Seungho, AU - Sung,Eunju, AU - Kim,Won Sool, Y1 - 2006/04/04/ PY - 2005/12/17/received PY - 2006/02/20/accepted PY - 2006/4/8/pubmed PY - 2007/1/9/medline PY - 2006/4/8/entrez SP - 329 EP - 35 JF - Diabetes research and clinical practice JO - Diabetes Res Clin Pract VL - 73 IS - 3 N2 - AIMS: We assessed whether the increased sequential changes in the fasting plasma glucose level (FPG) that is still within the normoglycemic range could be a predictor for future diabetes. METHODS: A prospective cohort study was conducted with 5296 male employees, aged 31-44 years. A sequential change in the FPG level was defined as the first follow-up FPG level minus the baseline FPG level. The incident diabetes was assessed at annual examinations during the next 4.1 years. Cox proportional hazard analyses were performed. RESULTS: During the 21,575.5 person-years follow-up among the 5,296 subjects, a total of 156 incident cases of type 2 diabetes occurred (116 cases among the 4,975 normoglycemic subjects and 40 cases among the 321 subjects with impaired fasting glucose). An increase in the FPG level from the baseline to the first follow-up, although still within the normoglycemic range (FPG<100 mg/dl), significantly predicted future diabetes: the multivariate hazard ratios associated with the sequential changes in the FPG of <-3, -3 to 3, 4-6, 7-9, and >9 mg/dl were 0.75, 1.00 (reference), 2.28, 3.28, and 6.10, respectively (p for trend <0.001). CONCLUSIONS: The increase of the sequential changes in the FPG level that were within the normal glucose range was associated with a higher risk for developing diabetes. Thus, conducting assessment for the serial changes in the FPG level may help to identify the young, healthy, normoglycemic individuals at risk for type 2 diabetes. SN - 0168-8227 UR - https://www.unboundmedicine.com/medline/citation/16600415/The_sequential_changes_in_the_fasting_plasma_glucose_levels_within_normoglycemic_range_predict_type_2_diabetes_in_healthy_young_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(06)00063-5 DB - PRIME DP - Unbound Medicine ER -