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Ketamine affects memory consolidation: differential effects in T-maze and passive avoidance paradigms in mice.
Neuroscience. 2006 Jul 07; 140(3):993-1002.N

Abstract

The effects of ketamine, an N-methyl-D-aspartate (NMDA) antagonist, on memory in animals have been limited to the sub-anesthetic dose given prior to training in previous studies. We evaluated the effects of post-training anesthetic doses of ketamine to selectively manipulate memory consolidation, and the effect of pre-retention sub-anesthetic doses of ketamine on memory retrieval in passive avoidance and T-maze tasks in mice. Repeated post-training anesthetic doses of ketamine impaired the consolidation of memory in the T-maze but not in passive avoidance paradigms. This impairment was not permanent but diminished 1-2 days after ketamine withdrawal. Sub-anesthetic post-training doses of ketamine (5 mg/kg) had no effect on memory consolidation, and larger doses (10, 20 and 50 mg/kg) did not influence the retrieval of memory in the T-maze. The data suggest that repeated anesthetic doses of ketamine block NMDA receptors and affect memory consolidation. Moreover, NMDA mechanisms antagonized by ketamine appear to be selectively involved in spatial (T-maze) memory mechanisms but may not be necessary for non-spatial (passive avoidance) memory consolidation.

Authors+Show Affiliations

Section of Cognitive Brain Research and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, PR China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16600517

Citation

Wang, J H., et al. "Ketamine Affects Memory Consolidation: Differential Effects in T-maze and Passive Avoidance Paradigms in Mice." Neuroscience, vol. 140, no. 3, 2006, pp. 993-1002.
Wang JH, Fu Y, Wilson FA, et al. Ketamine affects memory consolidation: differential effects in T-maze and passive avoidance paradigms in mice. Neuroscience. 2006;140(3):993-1002.
Wang, J. H., Fu, Y., Wilson, F. A., & Ma, Y. Y. (2006). Ketamine affects memory consolidation: differential effects in T-maze and passive avoidance paradigms in mice. Neuroscience, 140(3), 993-1002.
Wang JH, et al. Ketamine Affects Memory Consolidation: Differential Effects in T-maze and Passive Avoidance Paradigms in Mice. Neuroscience. 2006 Jul 7;140(3):993-1002. PubMed PMID: 16600517.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ketamine affects memory consolidation: differential effects in T-maze and passive avoidance paradigms in mice. AU - Wang,J H, AU - Fu,Y, AU - Wilson,F A W, AU - Ma,Y Y, PY - 2005/10/07/received PY - 2006/02/16/revised PY - 2006/02/24/accepted PY - 2006/4/8/pubmed PY - 2006/9/9/medline PY - 2006/4/8/entrez SP - 993 EP - 1002 JF - Neuroscience JO - Neuroscience VL - 140 IS - 3 N2 - The effects of ketamine, an N-methyl-D-aspartate (NMDA) antagonist, on memory in animals have been limited to the sub-anesthetic dose given prior to training in previous studies. We evaluated the effects of post-training anesthetic doses of ketamine to selectively manipulate memory consolidation, and the effect of pre-retention sub-anesthetic doses of ketamine on memory retrieval in passive avoidance and T-maze tasks in mice. Repeated post-training anesthetic doses of ketamine impaired the consolidation of memory in the T-maze but not in passive avoidance paradigms. This impairment was not permanent but diminished 1-2 days after ketamine withdrawal. Sub-anesthetic post-training doses of ketamine (5 mg/kg) had no effect on memory consolidation, and larger doses (10, 20 and 50 mg/kg) did not influence the retrieval of memory in the T-maze. The data suggest that repeated anesthetic doses of ketamine block NMDA receptors and affect memory consolidation. Moreover, NMDA mechanisms antagonized by ketamine appear to be selectively involved in spatial (T-maze) memory mechanisms but may not be necessary for non-spatial (passive avoidance) memory consolidation. SN - 0306-4522 UR - https://www.unboundmedicine.com/medline/citation/16600517/Ketamine_affects_memory_consolidation:_differential_effects_in_T_maze_and_passive_avoidance_paradigms_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(06)00320-4 DB - PRIME DP - Unbound Medicine ER -