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Anti-inflammatory and antinociceptive potential of Maclura pomifera (Rafin.) Schneider fruit extracts and its major isoflavonoids, scandenone and auriculasin.
J Ethnopharmacol. 2006 Sep 19; 107(2):169-74.JE

Abstract

The aqueous, ethanolic and chloroform extracts and two prenylated isoflavones: scandenone (I) and auriculasin (II), isolated from the fruits of Maclura pomifera (Rafin.) Schneider, were investigated for their in vivo anti-inflammatory and antinociceptive activity. For the anti-inflammatory activity, both carrageenan-induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema models and for the antinociceptive activity, p-benzoquinone-induced abdominal constriction test were used. Scandenone, the chloroform and the ethanolic extracts were shown to possess antinociceptive activity and anti-inflammatory activity on carrageenan-induced hind paw edema model at 100 mg/kg dose. The same compound and the extract were also found to be highly active in (TPA)-induced mouse ear edema model whereas auriculasin and the H(2)O extract showed to be inactive in all of the assays.

Authors+Show Affiliations

Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 6330, Ankara, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16600547

Citation

Kupeli, Esra, et al. "Anti-inflammatory and Antinociceptive Potential of Maclura Pomifera (Rafin.) Schneider Fruit Extracts and Its Major Isoflavonoids, Scandenone and Auriculasin." Journal of Ethnopharmacology, vol. 107, no. 2, 2006, pp. 169-74.
Kupeli E, Orhan I, Toker G, et al. Anti-inflammatory and antinociceptive potential of Maclura pomifera (Rafin.) Schneider fruit extracts and its major isoflavonoids, scandenone and auriculasin. J Ethnopharmacol. 2006;107(2):169-74.
Kupeli, E., Orhan, I., Toker, G., & Yesilada, E. (2006). Anti-inflammatory and antinociceptive potential of Maclura pomifera (Rafin.) Schneider fruit extracts and its major isoflavonoids, scandenone and auriculasin. Journal of Ethnopharmacology, 107(2), 169-74.
Kupeli E, et al. Anti-inflammatory and Antinociceptive Potential of Maclura Pomifera (Rafin.) Schneider Fruit Extracts and Its Major Isoflavonoids, Scandenone and Auriculasin. J Ethnopharmacol. 2006 Sep 19;107(2):169-74. PubMed PMID: 16600547.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory and antinociceptive potential of Maclura pomifera (Rafin.) Schneider fruit extracts and its major isoflavonoids, scandenone and auriculasin. AU - Kupeli,Esra, AU - Orhan,Ilkay, AU - Toker,Gulnur, AU - Yesilada,Erdem, Y1 - 2006/04/05/ PY - 2005/06/15/received PY - 2006/02/15/revised PY - 2006/02/28/accepted PY - 2006/4/8/pubmed PY - 2007/2/8/medline PY - 2006/4/8/entrez SP - 169 EP - 74 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 107 IS - 2 N2 - The aqueous, ethanolic and chloroform extracts and two prenylated isoflavones: scandenone (I) and auriculasin (II), isolated from the fruits of Maclura pomifera (Rafin.) Schneider, were investigated for their in vivo anti-inflammatory and antinociceptive activity. For the anti-inflammatory activity, both carrageenan-induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema models and for the antinociceptive activity, p-benzoquinone-induced abdominal constriction test were used. Scandenone, the chloroform and the ethanolic extracts were shown to possess antinociceptive activity and anti-inflammatory activity on carrageenan-induced hind paw edema model at 100 mg/kg dose. The same compound and the extract were also found to be highly active in (TPA)-induced mouse ear edema model whereas auriculasin and the H(2)O extract showed to be inactive in all of the assays. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/16600547/Anti_inflammatory_and_antinociceptive_potential_of_Maclura_pomifera__Rafin___Schneider_fruit_extracts_and_its_major_isoflavonoids_scandenone_and_auriculasin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(06)00123-1 DB - PRIME DP - Unbound Medicine ER -