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Intestinal oxalate absorption is higher in idiopathic calcium oxalate stone formers than in healthy controls: measurements with the [(13)C2]oxalate absorption test.

Abstract

PURPOSE

We assessed the importance of oxalate hyperabsorption for idiopathic calcium oxalate urolithiasis, oxalate absorption in healthy volunteers and recurrent calcium oxalate stone formers was compared.

MATERIALS AND METHODS

The [(13)C2]oxalate absorption test, a standardized, radioactivity-free test, was performed. On 2 days 24-hour urine was collected and an identical standard diet containing 800 mg Ca daily was maintained. On the morning of day 2 a capsule containing 0.37 mmol sodium [(13)C2]oxalate was ingested. A total of 120 healthy volunteers (60 women and 60 men) and 120 patients (30 women and 90 men) with idiopathic CaOx urolithiasis (60% or greater CaOx) were tested.

RESULTS

Mean intestinal oxalate absorption in the volunteers was 8.0 +/- 4.4%, and in the patients was 10.2 +/- 5.2% (p <0.001). There was no significant difference in mean absorption values between men and women within both groups. A high overlap between the absorption values of volunteers and patients was found. Only in the patient group did absorption values greater than 20% occur. Oxalate absorption correlated with oxalate excretion in the patients, r = 0.529 (p <0.01) and in the volunteers, r = 0.307 (p <0.01).

CONCLUSIONS

In high oxalate absorbers dietary oxalate has a significant role in oxalate excretion and, therefore, increases the risk of calcium oxalate stone formation.

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  • Authors+Show Affiliations

    ,

    Department of Urology (Division of Experimental Urology), University of Bonn, Bonn, Germany.

    , , ,

    Source

    The Journal of urology 175:5 2006 May pg 1711-5

    MeSH

    Adolescent
    Adult
    Calcium Oxalate
    Carbon Isotopes
    Female
    Humans
    Intestinal Absorption
    Male
    Middle Aged
    Oxalates
    Urinary Calculi

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16600737

    Citation

    Voss, Susanne, et al. "Intestinal Oxalate Absorption Is Higher in Idiopathic Calcium Oxalate Stone Formers Than in Healthy Controls: Measurements With the [(13)C2]oxalate Absorption Test." The Journal of Urology, vol. 175, no. 5, 2006, pp. 1711-5.
    Voss S, Hesse A, Zimmermann DJ, et al. Intestinal oxalate absorption is higher in idiopathic calcium oxalate stone formers than in healthy controls: measurements with the [(13)C2]oxalate absorption test. J Urol. 2006;175(5):1711-5.
    Voss, S., Hesse, A., Zimmermann, D. J., Sauerbruch, T., & von Unruh, G. E. (2006). Intestinal oxalate absorption is higher in idiopathic calcium oxalate stone formers than in healthy controls: measurements with the [(13)C2]oxalate absorption test. The Journal of Urology, 175(5), pp. 1711-5.
    Voss S, et al. Intestinal Oxalate Absorption Is Higher in Idiopathic Calcium Oxalate Stone Formers Than in Healthy Controls: Measurements With the [(13)C2]oxalate Absorption Test. J Urol. 2006;175(5):1711-5. PubMed PMID: 16600737.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Intestinal oxalate absorption is higher in idiopathic calcium oxalate stone formers than in healthy controls: measurements with the [(13)C2]oxalate absorption test. AU - Voss,Susanne, AU - Hesse,Albrecht, AU - Zimmermann,Diana J, AU - Sauerbruch,Tilman, AU - von Unruh,Gerd E, PY - 2005/05/09/received PY - 2006/4/8/pubmed PY - 2006/6/16/medline PY - 2006/4/8/entrez SP - 1711 EP - 5 JF - The Journal of urology JO - J. Urol. VL - 175 IS - 5 N2 - PURPOSE: We assessed the importance of oxalate hyperabsorption for idiopathic calcium oxalate urolithiasis, oxalate absorption in healthy volunteers and recurrent calcium oxalate stone formers was compared. MATERIALS AND METHODS: The [(13)C2]oxalate absorption test, a standardized, radioactivity-free test, was performed. On 2 days 24-hour urine was collected and an identical standard diet containing 800 mg Ca daily was maintained. On the morning of day 2 a capsule containing 0.37 mmol sodium [(13)C2]oxalate was ingested. A total of 120 healthy volunteers (60 women and 60 men) and 120 patients (30 women and 90 men) with idiopathic CaOx urolithiasis (60% or greater CaOx) were tested. RESULTS: Mean intestinal oxalate absorption in the volunteers was 8.0 +/- 4.4%, and in the patients was 10.2 +/- 5.2% (p <0.001). There was no significant difference in mean absorption values between men and women within both groups. A high overlap between the absorption values of volunteers and patients was found. Only in the patient group did absorption values greater than 20% occur. Oxalate absorption correlated with oxalate excretion in the patients, r = 0.529 (p <0.01) and in the volunteers, r = 0.307 (p <0.01). CONCLUSIONS: In high oxalate absorbers dietary oxalate has a significant role in oxalate excretion and, therefore, increases the risk of calcium oxalate stone formation. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/16600737/Intestinal_oxalate_absorption_is_higher_in_idiopathic_calcium_oxalate_stone_formers_than_in_healthy_controls:_measurements_with_the_[_13_C2]oxalate_absorption_test_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-5347(05)01001-3 DB - PRIME DP - Unbound Medicine ER -