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Limited effect of eicosapentaenoic acid on T-lymphocyte and natural killer cell numbers and functions in healthy young males.
Nutrition. 2006 May; 22(5):512-9.N

Abstract

OBJECTIVE

Greatly increasing the amount of long-chain omega-3 polyunsaturated fatty acids in the diet has been reported in some studies to decrease T-lymphocyte and natural killer functions. However, dose-response relations have not been identified. The objective of this study was to determine the effect of supplementing the diet of young male subjects with different amounts of an oil rich in eicosapentaenoic acid (EPA) on T-lymphocyte proliferation, cytokine production by T lymphocytes, and natural killer cell activity.

METHODS

In a placebo-controlled, double-blind, parallel study, healthy young (18 to 42 y) males were randomized to one of four supplements. These were placebo (no additional omega-3 polyunsaturated fatty acids) or different amounts of an EPA-rich oil that provided 1.35, 2.7, or 4.05 g/d of EPA for 12 wk. Blood samples were taken at baseline and after 12 wk.

RESULTS

Eicosapentaenoic acid was incorporated in a linear dose-response fashion into mononuclear cell phospholipids. EPA did not alter the proportions of T lymphocytes, helper T lymphocytes, cytotoxic T lymphocytes, B lymphocytes, or natural killer cells in the bloodstream. T-lymphocyte proliferation in response to concanavalin A and the production of the cytokines interleukin-2, interferon-gamma, and interleukin-10 were not affected by the different treatments. However, interleukin-4 production was increased with increasing intake of EPA. Natural killer cell activity was little affected by the treatments, although there was a trend for EPA to increase activity at a low effector-to-target cell ratio.

CONCLUSION

T-lymphocyte and natural killer cell numbers and function in healthy young males are little affected by supplemental EPA intakes up to 4 g/d.

Authors+Show Affiliations

Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, United Kingdom. eam@soton.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16600816

Citation

Miles, Elizabeth A., et al. "Limited Effect of Eicosapentaenoic Acid On T-lymphocyte and Natural Killer Cell Numbers and Functions in Healthy Young Males." Nutrition (Burbank, Los Angeles County, Calif.), vol. 22, no. 5, 2006, pp. 512-9.
Miles EA, Banerjee T, Wells SJ, et al. Limited effect of eicosapentaenoic acid on T-lymphocyte and natural killer cell numbers and functions in healthy young males. Nutrition. 2006;22(5):512-9.
Miles, E. A., Banerjee, T., Wells, S. J., & Calder, P. C. (2006). Limited effect of eicosapentaenoic acid on T-lymphocyte and natural killer cell numbers and functions in healthy young males. Nutrition (Burbank, Los Angeles County, Calif.), 22(5), 512-9.
Miles EA, et al. Limited Effect of Eicosapentaenoic Acid On T-lymphocyte and Natural Killer Cell Numbers and Functions in Healthy Young Males. Nutrition. 2006;22(5):512-9. PubMed PMID: 16600816.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Limited effect of eicosapentaenoic acid on T-lymphocyte and natural killer cell numbers and functions in healthy young males. AU - Miles,Elizabeth A, AU - Banerjee,Tapati, AU - Wells,Solenne J, AU - Calder,Philip C, PY - 2005/06/20/received PY - 2005/11/01/revised PY - 2005/11/22/accepted PY - 2006/4/8/pubmed PY - 2006/9/6/medline PY - 2006/4/8/entrez SP - 512 EP - 9 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 22 IS - 5 N2 - OBJECTIVE: Greatly increasing the amount of long-chain omega-3 polyunsaturated fatty acids in the diet has been reported in some studies to decrease T-lymphocyte and natural killer functions. However, dose-response relations have not been identified. The objective of this study was to determine the effect of supplementing the diet of young male subjects with different amounts of an oil rich in eicosapentaenoic acid (EPA) on T-lymphocyte proliferation, cytokine production by T lymphocytes, and natural killer cell activity. METHODS: In a placebo-controlled, double-blind, parallel study, healthy young (18 to 42 y) males were randomized to one of four supplements. These were placebo (no additional omega-3 polyunsaturated fatty acids) or different amounts of an EPA-rich oil that provided 1.35, 2.7, or 4.05 g/d of EPA for 12 wk. Blood samples were taken at baseline and after 12 wk. RESULTS: Eicosapentaenoic acid was incorporated in a linear dose-response fashion into mononuclear cell phospholipids. EPA did not alter the proportions of T lymphocytes, helper T lymphocytes, cytotoxic T lymphocytes, B lymphocytes, or natural killer cells in the bloodstream. T-lymphocyte proliferation in response to concanavalin A and the production of the cytokines interleukin-2, interferon-gamma, and interleukin-10 were not affected by the different treatments. However, interleukin-4 production was increased with increasing intake of EPA. Natural killer cell activity was little affected by the treatments, although there was a trend for EPA to increase activity at a low effector-to-target cell ratio. CONCLUSION: T-lymphocyte and natural killer cell numbers and function in healthy young males are little affected by supplemental EPA intakes up to 4 g/d. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/16600816/Limited_effect_of_eicosapentaenoic_acid_on_T_lymphocyte_and_natural_killer_cell_numbers_and_functions_in_healthy_young_males_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(06)00026-8 DB - PRIME DP - Unbound Medicine ER -