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A conjugated linoleic acid supplement containing trans-10, cis-12 reduces milk fat synthesis in lactating sheep.
J Dairy Sci. 2006 May; 89(5):1525-32.JD

Abstract

The efficacy of conjugated linoleic acid (CLA) supplements containing trans-10, cis-12 for reducing milk fat synthesis has been well documented in dairy cows, but studies with other ruminant species are less convincing, and there have been no investigations of this in sheep. Therefore, the current study was designed to determine whether trans-10, cis-12 CLA would inhibit milk fat synthesis in sheep. Twenty multiparous ewes in early lactation were paired and randomly allocated to 2 treatments: grass hay plus concentrate either unsupplemented (control) or supplemented with lipid-encapsulated CLA to provide 2.4 g/d of trans-10, cis-12 CLA. The CLA dose was based on published responses of dairy cows extrapolated to ewes on a metabolic body weight basis. The experimental design was a 2-period crossover with 10-d treatment periods separated by a 10-d interval. Compared with the control, CLA supplementation reduced milk fat content from 6.4 to 4.9% and reduced fat yield from 95 to 80 g/d. The CLA treatment also increased milk yield from 1,471 to 1,611 g/d and increased protein yield from 68 to 73 g/d. Milk protein content and DMI were unaffected by treatment. The reduction in milk fat yield was due to decreases in both de novo fatty acid synthesis and uptake of preformed fatty acids. Milk fat content of trans-10, cis-12 CLA was < 0.01 and 0.12 g/100 g of fatty acids for the control and CLA treatments, respectively. The transfer efficiency of trans-10, cis-12 CLA from the dietary supplement into milk fat was 3.8%. Results of the present study demonstrate that a CLA supplement containing trans-10, cis-12 CLA reduces milk fat synthesis in lactating sheep in a manner similar to dairy cows when fed at an equivalent dose (metabolic body weight basis). Furthermore, the nutrients spared by the reduction in milk fat coincided with an increase in milk and milk protein yield.

Authors+Show Affiliations

Department of Animal Science, Cornell University, Ithaca, NY 14853, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16606723

Citation

Lock, A L., et al. "A Conjugated Linoleic Acid Supplement Containing Trans-10, Cis-12 Reduces Milk Fat Synthesis in Lactating Sheep." Journal of Dairy Science, vol. 89, no. 5, 2006, pp. 1525-32.
Lock AL, Teles BM, Perfield JW, et al. A conjugated linoleic acid supplement containing trans-10, cis-12 reduces milk fat synthesis in lactating sheep. J Dairy Sci. 2006;89(5):1525-32.
Lock, A. L., Teles, B. M., Perfield, J. W., Bauman, D. E., & Sinclair, L. A. (2006). A conjugated linoleic acid supplement containing trans-10, cis-12 reduces milk fat synthesis in lactating sheep. Journal of Dairy Science, 89(5), 1525-32.
Lock AL, et al. A Conjugated Linoleic Acid Supplement Containing Trans-10, Cis-12 Reduces Milk Fat Synthesis in Lactating Sheep. J Dairy Sci. 2006;89(5):1525-32. PubMed PMID: 16606723.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A conjugated linoleic acid supplement containing trans-10, cis-12 reduces milk fat synthesis in lactating sheep. AU - Lock,A L, AU - Teles,B M, AU - Perfield,J W,2nd AU - Bauman,D E, AU - Sinclair,L A, PY - 2006/4/12/pubmed PY - 2006/7/14/medline PY - 2006/4/12/entrez SP - 1525 EP - 32 JF - Journal of dairy science JO - J Dairy Sci VL - 89 IS - 5 N2 - The efficacy of conjugated linoleic acid (CLA) supplements containing trans-10, cis-12 for reducing milk fat synthesis has been well documented in dairy cows, but studies with other ruminant species are less convincing, and there have been no investigations of this in sheep. Therefore, the current study was designed to determine whether trans-10, cis-12 CLA would inhibit milk fat synthesis in sheep. Twenty multiparous ewes in early lactation were paired and randomly allocated to 2 treatments: grass hay plus concentrate either unsupplemented (control) or supplemented with lipid-encapsulated CLA to provide 2.4 g/d of trans-10, cis-12 CLA. The CLA dose was based on published responses of dairy cows extrapolated to ewes on a metabolic body weight basis. The experimental design was a 2-period crossover with 10-d treatment periods separated by a 10-d interval. Compared with the control, CLA supplementation reduced milk fat content from 6.4 to 4.9% and reduced fat yield from 95 to 80 g/d. The CLA treatment also increased milk yield from 1,471 to 1,611 g/d and increased protein yield from 68 to 73 g/d. Milk protein content and DMI were unaffected by treatment. The reduction in milk fat yield was due to decreases in both de novo fatty acid synthesis and uptake of preformed fatty acids. Milk fat content of trans-10, cis-12 CLA was < 0.01 and 0.12 g/100 g of fatty acids for the control and CLA treatments, respectively. The transfer efficiency of trans-10, cis-12 CLA from the dietary supplement into milk fat was 3.8%. Results of the present study demonstrate that a CLA supplement containing trans-10, cis-12 CLA reduces milk fat synthesis in lactating sheep in a manner similar to dairy cows when fed at an equivalent dose (metabolic body weight basis). Furthermore, the nutrients spared by the reduction in milk fat coincided with an increase in milk and milk protein yield. SN - 1525-3198 UR - https://www.unboundmedicine.com/medline/citation/16606723/A_conjugated_linoleic_acid_supplement_containing_trans_10_cis_12_reduces_milk_fat_synthesis_in_lactating_sheep_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-0302(06)72220-2 DB - PRIME DP - Unbound Medicine ER -