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Altered brain white matter integrity in healthy carriers of the APOE epsilon4 allele: a risk for AD?
Neurology 2006; 66(7):1029-33Neur

Abstract

BACKGROUND

Previous research has shown that polymorphisms of apolipoprotein E (APOE) represent genetic risk factors for dementia and for cognitive impairment in the elderly. The neural mechanisms by which these genetic variations influence behavioral performance or clinical severity are not well understood.

METHODS

The authors used diffusion tensor imaging to investigate ultrastructural properties in brain white matter to detect pathologic processes that modify tissue integrity. Sixty participants were included in the study of which 30 were homozygous for the APOE epsilon3 allele, 10 were homozygous for the APOE epsilon4 allele, and 20 had the APOE epsilon34 allele combination. All individuals were non-demented, and the groups were matched on demographic variables and cognitive performance.

RESULTS

The results showed a decline in fractional anisotropy, a marker for white matter integrity, in the posterior corpus callosum of epsilon4 carriers compared to non-carriers. Additional sites of altered white matter integrity included the medial temporal lobe.

CONCLUSIONS

Although the mechanism underlying vulnerability of white matter tracts in APOE epsilon4 carriers is still unknown, these findings suggest that increased genetic risk for developing Alzheimer disease is associated with changes in microscopic white matter integrity well before the onset of dementia.

Authors+Show Affiliations

Department of Psychology, Umeå University, S-901 87 Umeå, Sweden. perssonj@umich.edu

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16606914

Citation

Persson, J, et al. "Altered Brain White Matter Integrity in Healthy Carriers of the APOE Epsilon4 Allele: a Risk for AD?" Neurology, vol. 66, no. 7, 2006, pp. 1029-33.
Persson J, Lind J, Larsson A, et al. Altered brain white matter integrity in healthy carriers of the APOE epsilon4 allele: a risk for AD? Neurology. 2006;66(7):1029-33.
Persson, J., Lind, J., Larsson, A., Ingvar, M., Cruts, M., Van Broeckhoven, C., ... Nyberg, L. (2006). Altered brain white matter integrity in healthy carriers of the APOE epsilon4 allele: a risk for AD? Neurology, 66(7), pp. 1029-33.
Persson J, et al. Altered Brain White Matter Integrity in Healthy Carriers of the APOE Epsilon4 Allele: a Risk for AD. Neurology. 2006 Apr 11;66(7):1029-33. PubMed PMID: 16606914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Altered brain white matter integrity in healthy carriers of the APOE epsilon4 allele: a risk for AD? AU - Persson,J, AU - Lind,J, AU - Larsson,A, AU - Ingvar,M, AU - Cruts,M, AU - Van Broeckhoven,C, AU - Adolfsson,R, AU - Nilsson,L-G, AU - Nyberg,L, PY - 2006/4/12/pubmed PY - 2006/5/4/medline PY - 2006/4/12/entrez SP - 1029 EP - 33 JF - Neurology JO - Neurology VL - 66 IS - 7 N2 - BACKGROUND: Previous research has shown that polymorphisms of apolipoprotein E (APOE) represent genetic risk factors for dementia and for cognitive impairment in the elderly. The neural mechanisms by which these genetic variations influence behavioral performance or clinical severity are not well understood. METHODS: The authors used diffusion tensor imaging to investigate ultrastructural properties in brain white matter to detect pathologic processes that modify tissue integrity. Sixty participants were included in the study of which 30 were homozygous for the APOE epsilon3 allele, 10 were homozygous for the APOE epsilon4 allele, and 20 had the APOE epsilon34 allele combination. All individuals were non-demented, and the groups were matched on demographic variables and cognitive performance. RESULTS: The results showed a decline in fractional anisotropy, a marker for white matter integrity, in the posterior corpus callosum of epsilon4 carriers compared to non-carriers. Additional sites of altered white matter integrity included the medial temporal lobe. CONCLUSIONS: Although the mechanism underlying vulnerability of white matter tracts in APOE epsilon4 carriers is still unknown, these findings suggest that increased genetic risk for developing Alzheimer disease is associated with changes in microscopic white matter integrity well before the onset of dementia. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/16606914/Altered_brain_white_matter_integrity_in_healthy_carriers_of_the_APOE_epsilon4_allele:_a_risk_for_AD L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=16606914 DB - PRIME DP - Unbound Medicine ER -