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[UV spectrophotometric assay of famotidine in combination with picrolonic acid, picrolinate].
Rev Med Chir Soc Med Nat Iasi. 2005 Apr-Jun; 109(2):422-5.RM

Abstract

Famotidine, belonging to H2-antagonist group, is a compound containing a thiazolic moiety and it is used in peptic ulcer therapy. This paper debates the possibility of developing a new ultraviolet spectrophotometric assessment by using the reaction between famotidine and picrolonic acid. We carried out our determinations at 362 nm, where the absorbency of famotidine - picrolonic acid complex is maximal, and we have established the optimal reaction conditions. This method was successfully applied for famotidine assay from pharmaceutical dosage forms.

Authors+Show Affiliations

Apostu M
Universitatea de Medicină si Farmacie Gr.T. Popa Iaşi, Facultatea de Farmacie, Disciplina de Chimie Analitică.
Bibire N
No affiliation info available
Dorneanu V
No affiliation info available

MeSH

Anti-Ulcer AgentsFamotidineHistamine H2 AntagonistsHumansIndicators and ReagentsPeptic UlcerPharmaceutical SolutionsPyrazolonesSpectrophotometry, Ultraviolet

Pub Type(s)

English Abstract
Journal Article

Language

rum

PubMed ID

16607813

Citation

Apostu, M, et al. "[UV Spectrophotometric Assay of Famotidine in Combination With Picrolonic Acid, Picrolinate]." Revista Medico-chirurgicala a Societatii De Medici Si Naturalisti Din Iasi, vol. 109, no. 2, 2005, pp. 422-5.
Apostu M, Bibire N, Dorneanu V. [UV spectrophotometric assay of famotidine in combination with picrolonic acid, picrolinate]. Rev Med Chir Soc Med Nat Iasi. 2005;109(2):422-5.
Apostu, M., Bibire, N., & Dorneanu, V. (2005). [UV spectrophotometric assay of famotidine in combination with picrolonic acid, picrolinate]. Revista Medico-chirurgicala a Societatii De Medici Si Naturalisti Din Iasi, 109(2), 422-5.
Apostu M, Bibire N, Dorneanu V. [UV Spectrophotometric Assay of Famotidine in Combination With Picrolonic Acid, Picrolinate]. Rev Med Chir Soc Med Nat Iasi. 2005 Apr-Jun;109(2):422-5. PubMed PMID: 16607813.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [UV spectrophotometric assay of famotidine in combination with picrolonic acid, picrolinate]. AU - Apostu,M, AU - Bibire,Nela, AU - Dorneanu,V, PY - 2006/4/13/pubmed PY - 2006/6/28/medline PY - 2006/4/13/entrez SP - 422 EP - 5 JF - Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi JO - Rev Med Chir Soc Med Nat Iasi VL - 109 IS - 2 N2 - Famotidine, belonging to H2-antagonist group, is a compound containing a thiazolic moiety and it is used in peptic ulcer therapy. This paper debates the possibility of developing a new ultraviolet spectrophotometric assessment by using the reaction between famotidine and picrolonic acid. We carried out our determinations at 362 nm, where the absorbency of famotidine - picrolonic acid complex is maximal, and we have established the optimal reaction conditions. This method was successfully applied for famotidine assay from pharmaceutical dosage forms. SN - 0048-7848 UR - https://www.unboundmedicine.com/medline/citation/16607813/[UV_spectrophotometric_assay_of_famotidine_in_combination_with_picrolonic_acid_picrolinate]_ DB - PRIME DP - Unbound Medicine ER -