[UV spectrophotometric assay of famotidine in combination with picrolonic acid, picrolinate].Rev Med Chir Soc Med Nat Iasi. 2005 Apr-Jun; 109(2):422-5.RM
Famotidine, belonging to H2-antagonist group, is a compound containing a thiazolic moiety and it is used in peptic ulcer therapy. This paper debates the possibility of developing a new ultraviolet spectrophotometric assessment by using the reaction between famotidine and picrolonic acid. We carried out our determinations at 362 nm, where the absorbency of famotidine - picrolonic acid complex is maximal, and we have established the optimal reaction conditions. This method was successfully applied for famotidine assay from pharmaceutical dosage forms.