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Simplified treatment of acute lower respiratory tract infection with azithromycin: a comparison with erythromycin and amoxycillin. European Azithromycin Study Group.
J Int Med Res. 1991 Sep-Oct; 19(5):373-83.JI

Abstract

In two randomized, multicentre studies azithromycin treatment (1.5 g in five or six doses over 5 days) was compared with erythromycin treatment (14 or 20 g in 28 or 40 doses over 7 or 10 days) and amoxycillin treatment (10.5 g in 21 doses over 7 days) in patients with acute respiratory tract infection. In the two separate studies, azithromycin gave complete clinical cure in 70% and 51%, respectively, of patients compared with in 60% of erythromycin- and 45% of amoxycillin-treated patients. Eradication of the main pathogens isolated at baseline (Haemophilus influenzae, Streptococcus pneumoniae and Staphylococcus aureus) was comparable in the azithromycin, erythromycin and amoxycillin treatment groups. Efficacy was not affected by the presence or absence of underlying pulmonary disease. There were no major abnormalities in laboratory safety parameters and adverse events, principally mild/moderate gastro-intestinal symptoms occurred in 5% or 15%, respectively, of azithromycin-treated patients compared with in 18% or 17%, respectively, of those receiving erythromycin or amoxycillin. It is concluded that azithromycin was as effective and better tolerated than erythromycin or amoxycillin.

Authors+Show Affiliations

Department of Clinical Research, Pfizer Central Research, Sandwich, UK.

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

1660824

Citation

Daniel, R. "Simplified Treatment of Acute Lower Respiratory Tract Infection With Azithromycin: a Comparison With Erythromycin and Amoxycillin. European Azithromycin Study Group." The Journal of International Medical Research, vol. 19, no. 5, 1991, pp. 373-83.
Daniel R. Simplified treatment of acute lower respiratory tract infection with azithromycin: a comparison with erythromycin and amoxycillin. European Azithromycin Study Group. J Int Med Res. 1991;19(5):373-83.
Daniel, R. (1991). Simplified treatment of acute lower respiratory tract infection with azithromycin: a comparison with erythromycin and amoxycillin. European Azithromycin Study Group. The Journal of International Medical Research, 19(5), 373-83.
Daniel R. Simplified Treatment of Acute Lower Respiratory Tract Infection With Azithromycin: a Comparison With Erythromycin and Amoxycillin. European Azithromycin Study Group. J Int Med Res. 1991 Sep-Oct;19(5):373-83. PubMed PMID: 1660824.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simplified treatment of acute lower respiratory tract infection with azithromycin: a comparison with erythromycin and amoxycillin. European Azithromycin Study Group. A1 - Daniel,R, PY - 1991/9/1/pubmed PY - 1991/9/1/medline PY - 1991/9/1/entrez SP - 373 EP - 83 JF - The Journal of international medical research JO - J Int Med Res VL - 19 IS - 5 N2 - In two randomized, multicentre studies azithromycin treatment (1.5 g in five or six doses over 5 days) was compared with erythromycin treatment (14 or 20 g in 28 or 40 doses over 7 or 10 days) and amoxycillin treatment (10.5 g in 21 doses over 7 days) in patients with acute respiratory tract infection. In the two separate studies, azithromycin gave complete clinical cure in 70% and 51%, respectively, of patients compared with in 60% of erythromycin- and 45% of amoxycillin-treated patients. Eradication of the main pathogens isolated at baseline (Haemophilus influenzae, Streptococcus pneumoniae and Staphylococcus aureus) was comparable in the azithromycin, erythromycin and amoxycillin treatment groups. Efficacy was not affected by the presence or absence of underlying pulmonary disease. There were no major abnormalities in laboratory safety parameters and adverse events, principally mild/moderate gastro-intestinal symptoms occurred in 5% or 15%, respectively, of azithromycin-treated patients compared with in 18% or 17%, respectively, of those receiving erythromycin or amoxycillin. It is concluded that azithromycin was as effective and better tolerated than erythromycin or amoxycillin. SN - 0300-0605 UR - https://www.unboundmedicine.com/medline/citation/1660824/Simplified_treatment_of_acute_lower_respiratory_tract_infection_with_azithromycin:_a_comparison_with_erythromycin_and_amoxycillin__European_Azithromycin_Study_Group_ L2 - https://journals.sagepub.com/doi/10.1177/030006059101900503?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -