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Comparison of protective effects between cultured Cordyceps militaris and natural Cordyceps sinensis against oxidative damage.
J Agric Food Chem. 2006 Apr 19; 54(8):3132-8.JA

Abstract

The Chinese herb DongChong-XiaCao originating from Cordyceps sinensis is widely used as a traditional medicine in China for treatment of a wide variety of diseases. The extracts of Cordyceps sinensis (CSE) and Cordyceps militaris (CME) are well-known for their biological effects. In the present study, the antioxidant efficiency of CME and CSE in protecting lipid, protein, and low-density lipoprotein (LDL) against oxidative damage was investigated. CME and CSE showed weakly inhibitory effect on liposome oxidation, that of CME being superior to that of CSE. As for the protein oxidation model system, the inhibitory effect of CME on protein oxidation was inferior to that of CSE. CME and CSE at 1.0 mg/mL showed 50.5 and 67.1% inhibition of LDL oxidation, respectively. The contents of bioactive ingredients cordycepin and adenosine in CME are higher than those of CSE; however, both cordycepin and adenosine showed no significant antioxidant activity as determined by the Trolox equivalent antioxidant capacity method. Polyphenolic and flavonoid contents are 60.2 and 0.598 microg/mL in CME and 31.8 and 0.616 microg/mL in CSE, respectively, which may in part be responsible for their antioxidant activities. In addition, a polysaccharide present in CME and CSE displayed antioxidant activity, which suggested that the activity might be derived partly from polysaccharides of CME and CSE. The tendency to scavenge the ABTS(*)(+) free radical and the reducing ability of CME and CSE display concentration-dependent manners, suggesting that CME and CSE may be potent hydrogen donators. On the basis of the results obtained, the protective effects of CME and CSE against oxidative damage of biomolecules are a result of their free radical scavenging abilities.

Authors+Show Affiliations

Yu HM
Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan Hsien, Taiwan, Republic of China.
Wang BS
No affiliation info available
Huang SC
No affiliation info available
Duh PD
No affiliation info available

MeSH

AntioxidantsCordycepsFlavonoidsLipid PeroxidationOxidation-ReductionOxidative StressPhenolsPlant ExtractsPolysaccharidesProteins

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16608242

Citation

Yu, Hui Mei, et al. "Comparison of Protective Effects Between Cultured Cordyceps Militaris and Natural Cordyceps Sinensis Against Oxidative Damage." Journal of Agricultural and Food Chemistry, vol. 54, no. 8, 2006, pp. 3132-8.
Yu HM, Wang BS, Huang SC, et al. Comparison of protective effects between cultured Cordyceps militaris and natural Cordyceps sinensis against oxidative damage. J Agric Food Chem. 2006;54(8):3132-8.
Yu, H. M., Wang, B. S., Huang, S. C., & Duh, P. D. (2006). Comparison of protective effects between cultured Cordyceps militaris and natural Cordyceps sinensis against oxidative damage. Journal of Agricultural and Food Chemistry, 54(8), 3132-8.
Yu HM, et al. Comparison of Protective Effects Between Cultured Cordyceps Militaris and Natural Cordyceps Sinensis Against Oxidative Damage. J Agric Food Chem. 2006 Apr 19;54(8):3132-8. PubMed PMID: 16608242.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of protective effects between cultured Cordyceps militaris and natural Cordyceps sinensis against oxidative damage. AU - Yu,Hui Mei, AU - Wang,Bor-Sen, AU - Huang,Shiow Chyn, AU - Duh,Pin-Der, PY - 2006/4/13/pubmed PY - 2006/6/21/medline PY - 2006/4/13/entrez SP - 3132 EP - 8 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 54 IS - 8 N2 - The Chinese herb DongChong-XiaCao originating from Cordyceps sinensis is widely used as a traditional medicine in China for treatment of a wide variety of diseases. The extracts of Cordyceps sinensis (CSE) and Cordyceps militaris (CME) are well-known for their biological effects. In the present study, the antioxidant efficiency of CME and CSE in protecting lipid, protein, and low-density lipoprotein (LDL) against oxidative damage was investigated. CME and CSE showed weakly inhibitory effect on liposome oxidation, that of CME being superior to that of CSE. As for the protein oxidation model system, the inhibitory effect of CME on protein oxidation was inferior to that of CSE. CME and CSE at 1.0 mg/mL showed 50.5 and 67.1% inhibition of LDL oxidation, respectively. The contents of bioactive ingredients cordycepin and adenosine in CME are higher than those of CSE; however, both cordycepin and adenosine showed no significant antioxidant activity as determined by the Trolox equivalent antioxidant capacity method. Polyphenolic and flavonoid contents are 60.2 and 0.598 microg/mL in CME and 31.8 and 0.616 microg/mL in CSE, respectively, which may in part be responsible for their antioxidant activities. In addition, a polysaccharide present in CME and CSE displayed antioxidant activity, which suggested that the activity might be derived partly from polysaccharides of CME and CSE. The tendency to scavenge the ABTS(*)(+) free radical and the reducing ability of CME and CSE display concentration-dependent manners, suggesting that CME and CSE may be potent hydrogen donators. On the basis of the results obtained, the protective effects of CME and CSE against oxidative damage of biomolecules are a result of their free radical scavenging abilities. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/16608242/Comparison_of_protective_effects_between_cultured_Cordyceps_militaris_and_natural_Cordyceps_sinensis_against_oxidative_damage_ DB - PRIME DP - Unbound Medicine ER -