Tags

Type your tag names separated by a space and hit enter

Adrenal function in hirsutism I. Diurnal change and response of plasma androstenedione, testosterone, 17-hydroxyprogesterone, cortisol, LH and FSH to dexamethasone and 1/2 unit of ACTH.
J Clin Endocrinol Metab. 1975 Jun; 40(6):988-1000.JC

Abstract

ACTH dependency of plasma androstenedione (A) and testosterone (T) was determined in normal and hirsute women by measuring the magnitude of change of A and T between the time of the cortisol (F) peak and F nadir in a diurnal study. There was a significant diurnal rhythm of A synchronous with F in both normal and hirsute women (P less than 0.01). Five of 12 hirsute women had a greater than normal diurnal swing of A (P less than 0.05), but only 2 of the 12 had a greater than normal diurnal swing of T. Responsiveness of A and T to 1/2 unit of intravenous ACTH was determined after dexamethasone 1 mg was given the night before. Plasma A and T were elevated in most of the hirsute women during acute ACTH suppression by dexamethasone, indicating ACTH-independent hypersecretion of androgens. Nine of 17 hirsute women had a greater than normal A response to ACTH (P less than 0.05). Those who had an exaggerated diurnal swing of A also had hyper-responsiveness of A secretion to ACTH. Only 2 hirsute women had an exaggerated T response to ACTH. Some T levels were decreased by ACTH. Seven of the 9 hiruste women who had an exaggerated A response to ACTH had a normal maximum F response, but a greater than normal 17-hydroxy-progesterone (17-OHP) response to ACTH with a high 17-OHP to F ratio, suggesting they have a mild but compensated reduction in 21-hydroxylase or 11beta-hydroxylase activity. Two women with hyper-responsiveness of A secretion had low F and 17-OHP responses to ACTH suggesting reduced C21 but intact C19 3beta-hydroxysteroid dehydrogenase-delta-5,-4 isomerase activity. These apparent reduced enzyme activity may not be congenital, but induced by an altered hormonal milieu such as an abnormal androgen-estrogen ratio. It is concluded that ACTH uniformly stimulated A secretion but not T secretion and that approximately 50% of the hirsute women had ACTH-dependent hypersecretion of A, but most of these also had concurrent ACTH-independent hypersecretion of androgens.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

166091

Citation

Givens, J R., et al. "Adrenal Function in Hirsutism I. Diurnal Change and Response of Plasma Androstenedione, Testosterone, 17-hydroxyprogesterone, Cortisol, LH and FSH to Dexamethasone and 1/2 Unit of ACTH." The Journal of Clinical Endocrinology and Metabolism, vol. 40, no. 6, 1975, pp. 988-1000.
Givens JR, Andersen RN, Ragland JB, et al. Adrenal function in hirsutism I. Diurnal change and response of plasma androstenedione, testosterone, 17-hydroxyprogesterone, cortisol, LH and FSH to dexamethasone and 1/2 unit of ACTH. J Clin Endocrinol Metab. 1975;40(6):988-1000.
Givens, J. R., Andersen, R. N., Ragland, J. B., Wiser, W. L., & Umstot, E. S. (1975). Adrenal function in hirsutism I. Diurnal change and response of plasma androstenedione, testosterone, 17-hydroxyprogesterone, cortisol, LH and FSH to dexamethasone and 1/2 unit of ACTH. The Journal of Clinical Endocrinology and Metabolism, 40(6), 988-1000.
Givens JR, et al. Adrenal Function in Hirsutism I. Diurnal Change and Response of Plasma Androstenedione, Testosterone, 17-hydroxyprogesterone, Cortisol, LH and FSH to Dexamethasone and 1/2 Unit of ACTH. J Clin Endocrinol Metab. 1975;40(6):988-1000. PubMed PMID: 166091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adrenal function in hirsutism I. Diurnal change and response of plasma androstenedione, testosterone, 17-hydroxyprogesterone, cortisol, LH and FSH to dexamethasone and 1/2 unit of ACTH. AU - Givens,J R, AU - Andersen,R N, AU - Ragland,J B, AU - Wiser,W L, AU - Umstot,E S, PY - 1975/6/1/pubmed PY - 1975/6/1/medline PY - 1975/6/1/entrez SP - 988 EP - 1000 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 40 IS - 6 N2 - ACTH dependency of plasma androstenedione (A) and testosterone (T) was determined in normal and hirsute women by measuring the magnitude of change of A and T between the time of the cortisol (F) peak and F nadir in a diurnal study. There was a significant diurnal rhythm of A synchronous with F in both normal and hirsute women (P less than 0.01). Five of 12 hirsute women had a greater than normal diurnal swing of A (P less than 0.05), but only 2 of the 12 had a greater than normal diurnal swing of T. Responsiveness of A and T to 1/2 unit of intravenous ACTH was determined after dexamethasone 1 mg was given the night before. Plasma A and T were elevated in most of the hirsute women during acute ACTH suppression by dexamethasone, indicating ACTH-independent hypersecretion of androgens. Nine of 17 hirsute women had a greater than normal A response to ACTH (P less than 0.05). Those who had an exaggerated diurnal swing of A also had hyper-responsiveness of A secretion to ACTH. Only 2 hirsute women had an exaggerated T response to ACTH. Some T levels were decreased by ACTH. Seven of the 9 hiruste women who had an exaggerated A response to ACTH had a normal maximum F response, but a greater than normal 17-hydroxy-progesterone (17-OHP) response to ACTH with a high 17-OHP to F ratio, suggesting they have a mild but compensated reduction in 21-hydroxylase or 11beta-hydroxylase activity. Two women with hyper-responsiveness of A secretion had low F and 17-OHP responses to ACTH suggesting reduced C21 but intact C19 3beta-hydroxysteroid dehydrogenase-delta-5,-4 isomerase activity. These apparent reduced enzyme activity may not be congenital, but induced by an altered hormonal milieu such as an abnormal androgen-estrogen ratio. It is concluded that ACTH uniformly stimulated A secretion but not T secretion and that approximately 50% of the hirsute women had ACTH-dependent hypersecretion of A, but most of these also had concurrent ACTH-independent hypersecretion of androgens. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/166091/Adrenal_function_in_hirsutism_I__Diurnal_change_and_response_of_plasma_androstenedione_testosterone_17_hydroxyprogesterone_cortisol_LH_and_FSH_to_dexamethasone_and_1/2_unit_of_ACTH_ DB - PRIME DP - Unbound Medicine ER -