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Neuropeptide y: role in emotion and alcohol dependence.
CNS Neurol Disord Drug Targets 2006; 5(2):181-95CN

Abstract

Neuropeptide Y (NPY) is considered to be an important neuromodulator in the regulation of emotional behavior. For example, NPY is consistently involved in anxiety-related behaviors and there is increasing support for a role of this peptide in mood disorders such as depression. Furthermore, recent evidence suggests that NPY has a significant role in the neurobiological response to alcohol, including alcohol consumption, dependence, and withdrawal. In addition, NPY is beginning to emerge as an important modulator in the etiology of alcoholism that is independent from the addictive and reinforcing properties of the traditional system commonly associated with dopamine and instead, is strongly associated with innate emotionality. The recent developments elucidating the role of NPY in emotion and alcohol dependence are reviewed and the potential of the NPY system as a novel therapeutic strategy in the treatment of anxiety, depression and alcohol-related disorders is examined.

Authors+Show Affiliations

Douglas Hospital Research Centre, Dept. of Psychiatry, McGill University, 6875 LaSalle Blvd., Montréal, QC, Canada, H4H 1R3.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16611091

Citation

Carvajal, C, et al. "Neuropeptide Y: Role in Emotion and Alcohol Dependence." CNS & Neurological Disorders Drug Targets, vol. 5, no. 2, 2006, pp. 181-95.
Carvajal C, Dumont Y, Quirion R. Neuropeptide y: role in emotion and alcohol dependence. CNS Neurol Disord Drug Targets. 2006;5(2):181-95.
Carvajal, C., Dumont, Y., & Quirion, R. (2006). Neuropeptide y: role in emotion and alcohol dependence. CNS & Neurological Disorders Drug Targets, 5(2), pp. 181-95.
Carvajal C, Dumont Y, Quirion R. Neuropeptide Y: Role in Emotion and Alcohol Dependence. CNS Neurol Disord Drug Targets. 2006;5(2):181-95. PubMed PMID: 16611091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuropeptide y: role in emotion and alcohol dependence. AU - Carvajal,C, AU - Dumont,Y, AU - Quirion,R, PY - 2006/4/14/pubmed PY - 2006/6/23/medline PY - 2006/4/14/entrez SP - 181 EP - 95 JF - CNS & neurological disorders drug targets JO - CNS Neurol Disord Drug Targets VL - 5 IS - 2 N2 - Neuropeptide Y (NPY) is considered to be an important neuromodulator in the regulation of emotional behavior. For example, NPY is consistently involved in anxiety-related behaviors and there is increasing support for a role of this peptide in mood disorders such as depression. Furthermore, recent evidence suggests that NPY has a significant role in the neurobiological response to alcohol, including alcohol consumption, dependence, and withdrawal. In addition, NPY is beginning to emerge as an important modulator in the etiology of alcoholism that is independent from the addictive and reinforcing properties of the traditional system commonly associated with dopamine and instead, is strongly associated with innate emotionality. The recent developments elucidating the role of NPY in emotion and alcohol dependence are reviewed and the potential of the NPY system as a novel therapeutic strategy in the treatment of anxiety, depression and alcohol-related disorders is examined. SN - 1871-5273 UR - https://www.unboundmedicine.com/medline/citation/16611091/Neuropeptide_y:_role_in_emotion_and_alcohol_dependence_ DB - PRIME DP - Unbound Medicine ER -