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Rutin improves glucose homeostasis in streptozotocin diabetic tissues by altering glycolytic and gluconeogenic enzymes.
J Biochem Mol Toxicol. 2006; 20(2):96-102.JB

Abstract

The role of rutin on carbohydrate metabolism in normal and streptozotocin (STZ)-induced diabetic rats was investigated in the present study. Administration of STZ led to a significant (p <0.05) increase in fasting plasma glucose and a decrease in insulin levels. The content of glycogen significantly (p <0.05) decreased in liver and muscle, but increased in kidney. The activity of hexokinase decreased whereas the activities of glucose-6-phosphatase and fructose-1,6-bisphosphatase significantly (p <0.05) increased in the tissues. Oral administration of rutin (100 mg/kg) to diabetic rats for a period of 45 days resulted in significant (p <0.05) alterations in the parameters studied but not in normal rats. A decrease of plasma glucose and increase in insulin levels were observed along with the restoration of glycogen content and the activities of carbohydrate metabolic enzymes in rutin-treated diabetic rats. The histopathological study of the pancreas revealed the protective role of rutin. There was an expansion of the islets and decreased fatty infiltrate of the islets in rutin-treated diabetic rats. In normal rats treated with rutin, we could not observe any significant change in all the parameters studied. Combined, these results show that rutin plays a positive role in carbohydrate metabolism and antioxidant status in diabetic rats.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar 608002, Tamil Nadu, India. ps_mainzenprince@yahoo.co.inNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16615078

Citation

Stanley Mainzen Prince, P, and N Kamalakkannan. "Rutin Improves Glucose Homeostasis in Streptozotocin Diabetic Tissues By Altering Glycolytic and Gluconeogenic Enzymes." Journal of Biochemical and Molecular Toxicology, vol. 20, no. 2, 2006, pp. 96-102.
Stanley Mainzen Prince P, Kamalakkannan N. Rutin improves glucose homeostasis in streptozotocin diabetic tissues by altering glycolytic and gluconeogenic enzymes. J Biochem Mol Toxicol. 2006;20(2):96-102.
Stanley Mainzen Prince, P., & Kamalakkannan, N. (2006). Rutin improves glucose homeostasis in streptozotocin diabetic tissues by altering glycolytic and gluconeogenic enzymes. Journal of Biochemical and Molecular Toxicology, 20(2), 96-102.
Stanley Mainzen Prince P, Kamalakkannan N. Rutin Improves Glucose Homeostasis in Streptozotocin Diabetic Tissues By Altering Glycolytic and Gluconeogenic Enzymes. J Biochem Mol Toxicol. 2006;20(2):96-102. PubMed PMID: 16615078.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rutin improves glucose homeostasis in streptozotocin diabetic tissues by altering glycolytic and gluconeogenic enzymes. AU - Stanley Mainzen Prince,P, AU - Kamalakkannan,N, PY - 2006/4/15/pubmed PY - 2006/6/16/medline PY - 2006/4/15/entrez SP - 96 EP - 102 JF - Journal of biochemical and molecular toxicology JO - J Biochem Mol Toxicol VL - 20 IS - 2 N2 - The role of rutin on carbohydrate metabolism in normal and streptozotocin (STZ)-induced diabetic rats was investigated in the present study. Administration of STZ led to a significant (p <0.05) increase in fasting plasma glucose and a decrease in insulin levels. The content of glycogen significantly (p <0.05) decreased in liver and muscle, but increased in kidney. The activity of hexokinase decreased whereas the activities of glucose-6-phosphatase and fructose-1,6-bisphosphatase significantly (p <0.05) increased in the tissues. Oral administration of rutin (100 mg/kg) to diabetic rats for a period of 45 days resulted in significant (p <0.05) alterations in the parameters studied but not in normal rats. A decrease of plasma glucose and increase in insulin levels were observed along with the restoration of glycogen content and the activities of carbohydrate metabolic enzymes in rutin-treated diabetic rats. The histopathological study of the pancreas revealed the protective role of rutin. There was an expansion of the islets and decreased fatty infiltrate of the islets in rutin-treated diabetic rats. In normal rats treated with rutin, we could not observe any significant change in all the parameters studied. Combined, these results show that rutin plays a positive role in carbohydrate metabolism and antioxidant status in diabetic rats. SN - 1095-6670 UR - https://www.unboundmedicine.com/medline/citation/16615078/Rutin_improves_glucose_homeostasis_in_streptozotocin_diabetic_tissues_by_altering_glycolytic_and_gluconeogenic_enzymes_ L2 - https://doi.org/10.1002/jbt.20117 DB - PRIME DP - Unbound Medicine ER -