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DNA immobilization and SAW response in ZnO nanotips grown on LiNbO3 substrates.
IEEE Trans Ultrason Ferroelectr Freq Control. 2006 Apr; 53(4):786-92.IT

Abstract

DNA immobilization enhancement is demonstrated in a structure consisting of ZnO nanotips on 128 degrees Y-cut LiNbO3. The ZnO nanotips are grown by metalorganic chemical vapor deposition (MOCVD) on the top of a SiO2 layer that is deposited and patterned on the LiNbO3 SAW delay path. The effects of ZnO nanotips on the SAW response are investigated. X-ray diffraction and scanning electron microscopy are used to analyze the ZnO nanotips, which are of single crystalline quality, and they are uniformly aligned with their c-axis perpendicular to the substrate surface. The photoluminescence (PL) spectrum of the ZnO nanotips shows strong near bandedge transition with insignificant deep level emission, confirming their good optical property. DNA immobilization enhancement is experimentally validated by radioactive labeling tests and SAW response changes. The ZnO nanotips enhance the DNA immobilization by a factor of 200 compared to ZnO film with flat surface. DNA hybridization with complementary and noncomplementary second strand DNA oligonucleotides is used to study the selective binding of the structure. This device structure possesses the advantages of both traditional SAW sensors and ZnO nanostructures.

Authors+Show Affiliations

Zhang Z
Department of Electrical and Computer Engineering, Rutgers University, Piscataway, NJ 08854-8058, USA.
Emanetoglu NW
No affiliation info available
Saraf G
No affiliation info available
Chen Y
No affiliation info available
Wu P
No affiliation info available
Zhong J
No affiliation info available
Lu Y
No affiliation info available
Chen J
No affiliation info available
Mirochnitchenko O
No affiliation info available
Inouye M
No affiliation info available

MeSH

Biosensing TechniquesCoated Materials, BiocompatibleCrystallizationDNAEquipment DesignEquipment Failure AnalysisNanotechnologyNiobiumOligonucleotide Array Sequence AnalysisOxidesUltrasonographyZinc Oxide

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16615583

Citation

Zhang, Zheng, et al. "DNA Immobilization and SAW Response in ZnO Nanotips Grown On LiNbO3 Substrates." IEEE Transactions On Ultrasonics, Ferroelectrics, and Frequency Control, vol. 53, no. 4, 2006, pp. 786-92.
Zhang Z, Emanetoglu NW, Saraf G, et al. DNA immobilization and SAW response in ZnO nanotips grown on LiNbO3 substrates. IEEE Trans Ultrason Ferroelectr Freq Control. 2006;53(4):786-92.
Zhang, Z., Emanetoglu, N. W., Saraf, G., Chen, Y., Wu, P., Zhong, J., Lu, Y., Chen, J., Mirochnitchenko, O., & Inouye, M. (2006). DNA immobilization and SAW response in ZnO nanotips grown on LiNbO3 substrates. IEEE Transactions On Ultrasonics, Ferroelectrics, and Frequency Control, 53(4), 786-92.
Zhang Z, et al. DNA Immobilization and SAW Response in ZnO Nanotips Grown On LiNbO3 Substrates. IEEE Trans Ultrason Ferroelectr Freq Control. 2006;53(4):786-92. PubMed PMID: 16615583.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - DNA immobilization and SAW response in ZnO nanotips grown on LiNbO3 substrates. AU - Zhang,Zheng, AU - Emanetoglu,Nuri William, AU - Saraf,Gaurav, AU - Chen,Yimin, AU - Wu,Pan, AU - Zhong,Jian, AU - Lu,Yicheng, AU - Chen,Jingqiu, AU - Mirochnitchenko,Oleg, AU - Inouye,Masayori, PY - 2006/4/18/pubmed PY - 2006/5/11/medline PY - 2006/4/18/entrez SP - 786 EP - 92 JF - IEEE transactions on ultrasonics, ferroelectrics, and frequency control JO - IEEE Trans Ultrason Ferroelectr Freq Control VL - 53 IS - 4 N2 - DNA immobilization enhancement is demonstrated in a structure consisting of ZnO nanotips on 128 degrees Y-cut LiNbO3. The ZnO nanotips are grown by metalorganic chemical vapor deposition (MOCVD) on the top of a SiO2 layer that is deposited and patterned on the LiNbO3 SAW delay path. The effects of ZnO nanotips on the SAW response are investigated. X-ray diffraction and scanning electron microscopy are used to analyze the ZnO nanotips, which are of single crystalline quality, and they are uniformly aligned with their c-axis perpendicular to the substrate surface. The photoluminescence (PL) spectrum of the ZnO nanotips shows strong near bandedge transition with insignificant deep level emission, confirming their good optical property. DNA immobilization enhancement is experimentally validated by radioactive labeling tests and SAW response changes. The ZnO nanotips enhance the DNA immobilization by a factor of 200 compared to ZnO film with flat surface. DNA hybridization with complementary and noncomplementary second strand DNA oligonucleotides is used to study the selective binding of the structure. This device structure possesses the advantages of both traditional SAW sensors and ZnO nanostructures. SN - 0885-3010 UR - https://www.unboundmedicine.com/medline/citation/16615583/DNA_immobilization_and_SAW_response_in_ZnO_nanotips_grown_on_LiNbO3_substrates_ DB - PRIME DP - Unbound Medicine ER -