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Studies of complex Ph translocations in cases with chronic myelogenous leukemia and one with acute lymphoblastic leukemia.
Cancer Genet Cytogenet 2006; 166(1):89-93CG

Abstract

The BCR/ABL gene fusion, the hallmark of chronic myelogenous leukemia (CML) is generated in 2-10% of patients by a variant Ph translocation involving 9q34, 22q11.2, and one or more additional genomic regions. The objective of this study was the characterization by conventional and molecular cytogenetics of complex variant Ph translocations present at diagnosis. FISH studies were performed in 7 cases using the LSI BCR/ABL ES probe allowing the detection of the fusion BCR/ABL gene on the Ph chromosome in all of them and 9q34 deletions in 2 cases. Three cryptic complex rearrangements were detected by FISH studies. The third and the fourth chromosome regions involved in the 8 complex variant translocations were: 1q21, 1p36, 5q31, 11q13, 12q13, 12p13, and 20q12. In conclusion, FISH studies have been useful in the detection of the BCR/ABL rearrangements and 9q34 deletions, and to identify complex rearrangements that differ from the ones previously established by conventional cytogenetics.

Authors+Show Affiliations

Hematopathology Unit, Hospital Clínic. Villarroel, 170, 08036, Barcelona, Catalonia, Spain. dcosta@clinic.ub.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16616117

Citation

Costa, Dolors, et al. "Studies of Complex Ph Translocations in Cases With Chronic Myelogenous Leukemia and One With Acute Lymphoblastic Leukemia." Cancer Genetics and Cytogenetics, vol. 166, no. 1, 2006, pp. 89-93.
Costa D, Carrió A, Madrigal I, et al. Studies of complex Ph translocations in cases with chronic myelogenous leukemia and one with acute lymphoblastic leukemia. Cancer Genet Cytogenet. 2006;166(1):89-93.
Costa, D., Carrió, A., Madrigal, I., Arias, A., Valera, A., Colomer, D., ... Campo, E. (2006). Studies of complex Ph translocations in cases with chronic myelogenous leukemia and one with acute lymphoblastic leukemia. Cancer Genetics and Cytogenetics, 166(1), pp. 89-93.
Costa D, et al. Studies of Complex Ph Translocations in Cases With Chronic Myelogenous Leukemia and One With Acute Lymphoblastic Leukemia. Cancer Genet Cytogenet. 2006 Apr 1;166(1):89-93. PubMed PMID: 16616117.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Studies of complex Ph translocations in cases with chronic myelogenous leukemia and one with acute lymphoblastic leukemia. AU - Costa,Dolors, AU - Carrió,Ana, AU - Madrigal,Irene, AU - Arias,Amparo, AU - Valera,Alexandra, AU - Colomer,Dolors, AU - Aguilar,Josep Lluís, AU - Teixido,Montse, AU - Camós,Mireia, AU - Cervantes,Francisco, AU - Campo,Elías, PY - 2005/06/01/received PY - 2005/08/17/revised PY - 2005/08/24/accepted PY - 2006/4/18/pubmed PY - 2006/5/17/medline PY - 2006/4/18/entrez SP - 89 EP - 93 JF - Cancer genetics and cytogenetics JO - Cancer Genet. Cytogenet. VL - 166 IS - 1 N2 - The BCR/ABL gene fusion, the hallmark of chronic myelogenous leukemia (CML) is generated in 2-10% of patients by a variant Ph translocation involving 9q34, 22q11.2, and one or more additional genomic regions. The objective of this study was the characterization by conventional and molecular cytogenetics of complex variant Ph translocations present at diagnosis. FISH studies were performed in 7 cases using the LSI BCR/ABL ES probe allowing the detection of the fusion BCR/ABL gene on the Ph chromosome in all of them and 9q34 deletions in 2 cases. Three cryptic complex rearrangements were detected by FISH studies. The third and the fourth chromosome regions involved in the 8 complex variant translocations were: 1q21, 1p36, 5q31, 11q13, 12q13, 12p13, and 20q12. In conclusion, FISH studies have been useful in the detection of the BCR/ABL rearrangements and 9q34 deletions, and to identify complex rearrangements that differ from the ones previously established by conventional cytogenetics. SN - 0165-4608 UR - https://www.unboundmedicine.com/medline/citation/16616117/Studies_of_complex_Ph_translocations_in_cases_with_chronic_myelogenous_leukemia_and_one_with_acute_lymphoblastic_leukemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-4608(05)00506-6 DB - PRIME DP - Unbound Medicine ER -