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Iron and copper accumulation in the brain of coxsackievirus-infected mice exposed to cadmium.
Environ Res. 2006 Nov; 102(3):308-13.ER

Abstract

Cadmium (Cd) is a potentially toxic metal widely distributed in the environment and known to cause adverse health effects in humans. During coxsackievirus infection, the concentrations of essential and nonessential trace elements (e.g., iron (Fe), copper (Cu), and Cd) change in different target organs of the infection. Fe and Cu are recognized cofactors in host defence reactions, and Fe is known to be associated with certain pathological conditions of the brain. However, whether nonessential trace elements could influence the balance of essential trace elements in the brain is unknown. In this study the brain Fe, Cu, and Cd contents were measured through inductively coupled plasma mass spectrometry and their distributions determined by nuclear microscopy in the early phase (day 3) of coxsackievirus B3 (CB3) infection in nonexposed and in Cd-exposed female Balb/c mice. In CB3 infection the brain is a well-known target that has not been studied with regard to trace element balance. The brain concentration of Cu compared with that of noninfected control mice was increased by 9% (P < 0.05) in infected mice not exposed to Cd and by 10% (not significant) in infected Cd-exposed mice. A similar response was seen for Fe, which in infected Cd-exposed mice, compared to noninfected control mice, tended to increase by 16%. Cu showed an even tissue distribution, whereas Fe was distributed in focal deposits. Changes in Cd concentration in the brain of infected mice were less consistent but evenly distributed. Further studies are needed to define whether the accumulation and distribution of trace elements in the brain have an impact on brain function.

Authors+Show Affiliations

Ilbäck NG
Section of Infectious Diseases, Department of Medical Sciences, Uppsala University Hospital, S-751 85 Uppsala, Sweden. nils-gunnar.ilback@slv.se
Lindh U
No affiliation info available
Minqin R
No affiliation info available
Friman G
No affiliation info available
Watt F
No affiliation info available

MeSH

AnimalsBrainCadmiumCopperCoxsackievirus InfectionsEnterovirusEnvironmental ExposureFemaleIronMiceMice, Inbred BALB CTrace Elements

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16616136

Citation

Ilbäck, N-G, et al. "Iron and Copper Accumulation in the Brain of Coxsackievirus-infected Mice Exposed to Cadmium." Environmental Research, vol. 102, no. 3, 2006, pp. 308-13.
Ilbäck NG, Lindh U, Minqin R, et al. Iron and copper accumulation in the brain of coxsackievirus-infected mice exposed to cadmium. Environ Res. 2006;102(3):308-13.
Ilbäck, N. G., Lindh, U., Minqin, R., Friman, G., & Watt, F. (2006). Iron and copper accumulation in the brain of coxsackievirus-infected mice exposed to cadmium. Environmental Research, 102(3), 308-13.
Ilbäck NG, et al. Iron and Copper Accumulation in the Brain of Coxsackievirus-infected Mice Exposed to Cadmium. Environ Res. 2006;102(3):308-13. PubMed PMID: 16616136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iron and copper accumulation in the brain of coxsackievirus-infected mice exposed to cadmium. AU - Ilbäck,N-G, AU - Lindh,U, AU - Minqin,R, AU - Friman,G, AU - Watt,F, Y1 - 2006/04/17/ PY - 2005/10/26/received PY - 2006/01/31/revised PY - 2006/02/09/accepted PY - 2006/4/18/pubmed PY - 2006/12/23/medline PY - 2006/4/18/entrez SP - 308 EP - 13 JF - Environmental research JO - Environ Res VL - 102 IS - 3 N2 - Cadmium (Cd) is a potentially toxic metal widely distributed in the environment and known to cause adverse health effects in humans. During coxsackievirus infection, the concentrations of essential and nonessential trace elements (e.g., iron (Fe), copper (Cu), and Cd) change in different target organs of the infection. Fe and Cu are recognized cofactors in host defence reactions, and Fe is known to be associated with certain pathological conditions of the brain. However, whether nonessential trace elements could influence the balance of essential trace elements in the brain is unknown. In this study the brain Fe, Cu, and Cd contents were measured through inductively coupled plasma mass spectrometry and their distributions determined by nuclear microscopy in the early phase (day 3) of coxsackievirus B3 (CB3) infection in nonexposed and in Cd-exposed female Balb/c mice. In CB3 infection the brain is a well-known target that has not been studied with regard to trace element balance. The brain concentration of Cu compared with that of noninfected control mice was increased by 9% (P < 0.05) in infected mice not exposed to Cd and by 10% (not significant) in infected Cd-exposed mice. A similar response was seen for Fe, which in infected Cd-exposed mice, compared to noninfected control mice, tended to increase by 16%. Cu showed an even tissue distribution, whereas Fe was distributed in focal deposits. Changes in Cd concentration in the brain of infected mice were less consistent but evenly distributed. Further studies are needed to define whether the accumulation and distribution of trace elements in the brain have an impact on brain function. SN - 0013-9351 UR - https://www.unboundmedicine.com/medline/citation/16616136/Iron_and_copper_accumulation_in_the_brain_of_coxsackievirus_infected_mice_exposed_to_cadmium_ DB - PRIME DP - Unbound Medicine ER -