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Aleatory clinical study comparing otilonium bromide with a fiber-rich diet in the treatment of irritable bowel syndrome.
Ital J Gastroenterol. 1991 Nov; 23(8 Suppl 1):67-70.IJ

Abstract

We studied 114 patients affected by irritable bowel syndrome (IBS) (group A = 53 patients, group B = 61). Group A received diet with high content of roughage (20 g of fibers) and 10 g of bran, group B received otilonium bromide (OB) 40mg tid and normal diet (10-15 g of fibers). Abdominal pain, abdominal distension, bowel movements were evaluated before treatment (T0) at the end (T24) and after 12 months (T12). In group B otilonium bromide induced a significant improvement (p less than 0.01) of abdominal pain and distension when comparing T0 with T24. In group A diet produced an improvement, albeit not significant, of the aforementioned parameters at T24. On the basis of our data OB seems to be more effective than a high-fiber diet in the treatment of IBS.

Authors+Show Affiliations

Gastroenterology Unit, Germans Trias i Pujol Hospital Badalona, Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

1661630

Citation

Villagrasa, M, et al. "Aleatory Clinical Study Comparing Otilonium Bromide With a Fiber-rich Diet in the Treatment of Irritable Bowel Syndrome." The Italian Journal of Gastroenterology, vol. 23, no. 8 Suppl 1, 1991, pp. 67-70.
Villagrasa M, Boix J, Humbert P, et al. Aleatory clinical study comparing otilonium bromide with a fiber-rich diet in the treatment of irritable bowel syndrome. Ital J Gastroenterol. 1991;23(8 Suppl 1):67-70.
Villagrasa, M., Boix, J., Humbert, P., & Quer, J. C. (1991). Aleatory clinical study comparing otilonium bromide with a fiber-rich diet in the treatment of irritable bowel syndrome. The Italian Journal of Gastroenterology, 23(8 Suppl 1), 67-70.
Villagrasa M, et al. Aleatory Clinical Study Comparing Otilonium Bromide With a Fiber-rich Diet in the Treatment of Irritable Bowel Syndrome. Ital J Gastroenterol. 1991;23(8 Suppl 1):67-70. PubMed PMID: 1661630.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aleatory clinical study comparing otilonium bromide with a fiber-rich diet in the treatment of irritable bowel syndrome. AU - Villagrasa,M, AU - Boix,J, AU - Humbert,P, AU - Quer,J C, PY - 1991/11/1/pubmed PY - 1991/11/1/medline PY - 1991/11/1/entrez SP - 67 EP - 70 JF - The Italian journal of gastroenterology JO - Ital J Gastroenterol VL - 23 IS - 8 Suppl 1 N2 - We studied 114 patients affected by irritable bowel syndrome (IBS) (group A = 53 patients, group B = 61). Group A received diet with high content of roughage (20 g of fibers) and 10 g of bran, group B received otilonium bromide (OB) 40mg tid and normal diet (10-15 g of fibers). Abdominal pain, abdominal distension, bowel movements were evaluated before treatment (T0) at the end (T24) and after 12 months (T12). In group B otilonium bromide induced a significant improvement (p less than 0.01) of abdominal pain and distension when comparing T0 with T24. In group A diet produced an improvement, albeit not significant, of the aforementioned parameters at T24. On the basis of our data OB seems to be more effective than a high-fiber diet in the treatment of IBS. SN - 0392-0623 UR - https://www.unboundmedicine.com/medline/citation/1661630/Aleatory_clinical_study_comparing_otilonium_bromide_with_a_fiber_rich_diet_in_the_treatment_of_irritable_bowel_syndrome_ DB - PRIME DP - Unbound Medicine ER -