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The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells.
Cancer Cell. 2006 Apr; 9(4):301-12.CC

Abstract

One of the most exciting areas of current research in the cannabinoid field is the study of the potential application of these compounds as antitumoral drugs. Here, we describe the signaling pathway that mediates cannabinoid-induced apoptosis of tumor cells. By using a wide array of experimental approaches, we identify the stress-regulated protein p8 (also designated as candidate of metastasis 1) as an essential mediator of cannabinoid antitumoral action and show that p8 upregulation is dependent on de novo-synthesized ceramide. We also observe that p8 mediates its apoptotic effect via upregulation of the endoplasmic reticulum stress-related genes ATF-4, CHOP, and TRB3. Activation of this pathway may constitute a potential therapeutic strategy for inhibiting tumor growth.

Authors+Show Affiliations

Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16616335

Citation

Carracedo, Arkaitz, et al. "The Stress-regulated Protein P8 Mediates Cannabinoid-induced Apoptosis of Tumor Cells." Cancer Cell, vol. 9, no. 4, 2006, pp. 301-12.
Carracedo A, Lorente M, Egia A, et al. The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells. Cancer Cell. 2006;9(4):301-12.
Carracedo, A., Lorente, M., Egia, A., Blázquez, C., García, S., Giroux, V., Malicet, C., Villuendas, R., Gironella, M., González-Feria, L., Piris, M. A., Iovanna, J. L., Guzmán, M., & Velasco, G. (2006). The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells. Cancer Cell, 9(4), 301-12.
Carracedo A, et al. The Stress-regulated Protein P8 Mediates Cannabinoid-induced Apoptosis of Tumor Cells. Cancer Cell. 2006;9(4):301-12. PubMed PMID: 16616335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells. AU - Carracedo,Arkaitz, AU - Lorente,Mar, AU - Egia,Ainara, AU - Blázquez,Cristina, AU - García,Stephane, AU - Giroux,Valentin, AU - Malicet,Cedric, AU - Villuendas,Raquel, AU - Gironella,Meritxell, AU - González-Feria,Luis, AU - Piris,Miguel Angel, AU - Iovanna,Juan L, AU - Guzmán,Manuel, AU - Velasco,Guillermo, PY - 2005/09/22/received PY - 2006/01/07/revised PY - 2006/03/09/accepted PY - 2006/4/18/pubmed PY - 2006/5/17/medline PY - 2006/4/18/entrez SP - 301 EP - 12 JF - Cancer cell JO - Cancer Cell VL - 9 IS - 4 N2 - One of the most exciting areas of current research in the cannabinoid field is the study of the potential application of these compounds as antitumoral drugs. Here, we describe the signaling pathway that mediates cannabinoid-induced apoptosis of tumor cells. By using a wide array of experimental approaches, we identify the stress-regulated protein p8 (also designated as candidate of metastasis 1) as an essential mediator of cannabinoid antitumoral action and show that p8 upregulation is dependent on de novo-synthesized ceramide. We also observe that p8 mediates its apoptotic effect via upregulation of the endoplasmic reticulum stress-related genes ATF-4, CHOP, and TRB3. Activation of this pathway may constitute a potential therapeutic strategy for inhibiting tumor growth. SN - 1535-6108 UR - https://www.unboundmedicine.com/medline/citation/16616335/The_stress_regulated_protein_p8_mediates_cannabinoid_induced_apoptosis_of_tumor_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1535-6108(06)00085-7 DB - PRIME DP - Unbound Medicine ER -